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Cell Polarity Signaling (GRS)

Gordon Research Seminar

From Molecules to Organs: How to Build a Polarized Organism

June 2 - 3, 2018

Chairs

and

Conference Description

The Gordon Research Seminar (GRS) on Cell Polarity Signaling (June 2-3, 2018) will gather young scientists (graduate students and postdoctoral fellows) to present and discuss their latest cutting-edge findings in this exciting field of research, whilst promoting career networking and mentoring.

All organisms, from bacteria to plants to humans, require highly organized internal structures to survive. Such a refined arrangement relies on Cell Polarity. This ability to respond to external cues by establishing and maintaining an asymmetric distribution of cellular components along a polarity axis is of the utmost importance for a cell to fulfill its function. Exploring a wide range of in silico, in vitro and in vivo models, this seminar will focus on the molecular mechanisms controlling single cell polarization while also concentrating on how do groups of cells coordinate their internal polarized state to provide polarity axis in tissues. Finally, how disrupted cell polarity is involved in disease initiation and progression will be discussed.

Related Meeting

This GRS will be held in conjunction with the "Cell Polarity Signaling" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Morphogenesis in Development Discussion Leaders: and
3:45 pm - 4:20 pm	"Polarity and Morphogenesis in Development"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Molecular Mechanisms of Cell Polarization This session will focus on the molecular details of polarity protein networks. Have new players or novel interactions between key components of these networks been found? Should we envisage any change in paradigms leading to revision of how polarity axis is established and maintained in different single cell models (from Dictyostelium directed migration to asymmetric partitioning of epithelial cell, neuroblast, oocytes or zygotes etc…)? Emphasis will be given to cue-reading and signal transduction strategies to polarize where and when it is required; but also to the elaboration of mathematical model integrating molecular details to reach systems-level scale, to identify the core features of polarity pattern formation. Discussion Leaders: and
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Establishment of Apical and Basolateral Polarity in the Embryonic Intestinal Epithelium"
8:00 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"Novel Role of the C. elegans Apoptotic Pathway in Asymmetric Cell Division"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Age-Selective Segregation of Peroxisomes During Stem Cell Division Is Mediated by the Mitotic Spindle"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	"Interplay of Ubiquitination and Palmitoylation in Regulation of Fat-Hippo Signaling"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Cell Polarity and Morphogenesis: How to Build a Polarized Tissue? This session is dedicated to tissue polarity homeostasis. First we will focus on how animal or plant tissues acquire their “long-range” apico-basal and planar cell polarity. More specifically, the focus will be on how do groups of cells coordinate their internal polarized state to generate a more global, long-lasting axis of polarity (including polarized collective migration). Then we will ask how do tissues maintain their polarized state during wound healing, cell divisions, cell extrusions and cell movement (tissue polarity homeostasis)? Discussion Leaders: and
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Oxidative Stress Orchestrates Cell Polarity to Promote Embryonic Wound Healing"
9:30 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Septate Junctions Coordinate Growth and Intercalation of Stem Cell Progeny During Epithelial Organ Turnover"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	"The Basolateral Scribble Complex Promotes Cooperativity During Collective Migration"
10:20 am - 10:25 am	Discussion
10:25 am - 10:45 am	"Drosophila Neuroblast Ingression: How Actomyosin and Apical Trafficking Drive an Epithelial to Mesenchymal Transition"
10:45 am - 10:50 am	Discussion
10:50 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Cell Polarity and Diseases: Can Polarity Loss Cause Disease? This session will conclude the seminar by looking at the impact of polarity alteration on disease progression. One key question to answer will be whether polarity loss can initiate tumour development. Numbers of studies have identified polarity genes as oncogenes or tumour suppressors in different animal models. But due to the impact of polarity genes loss on deeper epithelial organization, it has always been hard to acknowledge that it is the initial loss of polarity that drives tumour initiation. Whether polarity loss favours transformation is still largely unknown. Discussion Leader:
1:30 pm - 1:40 pm	Introduction by Discussion Leader
1:40 pm - 2:00 pm	and "Polarity Signaling Governs Epithelial Homeostasis by Coupling Cortical Contractility and Mitotic Fidelity"
2:00 pm - 2:05 pm	Discussion
2:05 pm - 2:25 pm	"Cdc42 Acts as a Tumor Suppressor in Liver by Regulating Hepatocyte Differentiation Through PAK1-YAP Axis"
2:25 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number R13HD095644. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Cell Polarity Signaling

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