Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: The Finer Points of Diffraction Data
3:45 pm - 4:20 pm
"Up Close with Your Data"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Experimentally (Pump-)Probing Biological Systems: Methods for Data Collection and Analysis
In this session, we will discuss the experimental and computational methods around the new fields in X-ray Crystallography, including single- and multi-crystal data collections, time-resolved experiments, X-ray Free Electron Lasers, and others.
7:30 pm - 7:50 pm
"Recent Developments in Computational Methods for Two-Dimensional Serial Femtosecond Crystallography: Paving the Way to the Time-Resolved Study of Large-Scale Movements in Membrane Proteins"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Profile Modelling, Refinement and Integration of Synchrotron Stills"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Obtaining Better Protein Structure Models by Systematically Using Homology"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Crystallographic Occupancy of Fragment Ligands Is Consistent and Reproducible"
9:20 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Deploying New Techniques: Biological Structures as We've Never Seen Them Before
This session will focus on the application of new crystallographic techniques to study biological systems. In particular, we will focus on outcomes that would not have been previously possible using "traditional" techniques.
9:00 am - 9:20 am
"XFEL Diffraction Studies of the Oxygen-Evolving Complex of Photosystem II"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Towards Millisecond Monochromatic Protein Time-Resolved X-Ray Crystallography at Synchrotrons"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"The Inhibition Mechanism of Human 20S Proteasomes Enables Inhibitor Design"
10:10 am - 10:15 am
Discussion
10:15 am - 10:35 am
"The Target Validation Using Structure-Based Targeting of Orthologous Pathogen Proteins (STOPP) Approach"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Mechanism or X-Ray Damage? A Case Study with Xylose Isomerase"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: A Home of One's Own: From Starting a Lab to Funding an Institute
In this session, we will hear three talks of building something of your own. We will hear what it's like to make the move from Post-Doc to Principal Investigator (PI), as well as how you go about funding a new institute.
1:30 pm - 1:45 pm
"Nucleating a Well-Ordered Crystallography Lab"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
"Navigating the Terrain as a New Assistant Professor: What to Avoid and What to Embrace"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
"Funding an Institute: Things I Wish I'd Known (or 'Lessons Learned the Hard Way'!)"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes