| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:35 pm - 9:30 pm | Keynote Lectures |
| Discussion Leader: Raghu Kalluri (MD Anderson Cancer Center, Houston, TX) |
| 7:35 pm - 7:55 pm | Joseph Schlessinger (Yale University, New Haven, CT)
"Cell signaling by receptor tyrosine kinases: from basic principles to cancer therapy" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Gregg Semenza (Johns Hopkins, Baltimore, MD)
"Control of tumor vascularization and vascular modulation by hypoxia-inducible factor 1"
|
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:55 pm | William Kaelin (Dana Farber Cancer Institute, Boston, MA)
"The VHL tumor suppressor: insights into oxygen sensing and cancer metabolism"
|
| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:25 pm | James D. Watson (Cold Spring Harbor Laboratory, New York, NY)
"Unfolded proteins in advanced cancer" |
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Hypoxia, Metabolism and Angiogenesis |
| Discussion Leader: Peter Carmeliet (VIB, Leuven, Belgium) |
| 9:00 am - 9:20 am | Celeste Simon (University of Pennsylvania School of Medicine, Philadelphia)
"Hypoxia, angiogenesis, and colorectal cancer" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Peter Carmeliet (VIB, Leuven, Belgium)
"Control of vascular branching by endothelial cell metabolism" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Group Photo / Coffee Break |
| 10:30 am - 10:50 am | Kari Alitalo (University of Helsinki, Finland)
"Combinatorial targeting of angiogenic pathways" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Zoltan Arany (Beth Israel Deaconess Medical Center, Boston, MA)
"PGC-1alpha and angiogenesis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Debabrata Mukhopadhyay (Mayo Clinic, Rochester, MN)
Short Talk selected from abstracts: "Neuropilin-1 maintains mitochondrial homeostasis in cardiac and vascular smooth muscle cells"
|
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Andreas Moller (Queensland Institute of Medical Research, Brisbane, Australia)
Short Talk selected from abstracts: "The Siah2 ubiquitin ligase is important for tumor neo-angiogenesis"
|
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Patrik Andersson (Karolinska Institutet, Stockholm, Sweden)
Short Talk selected from abstracts: "Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis"
|
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Valerie LeBleu (MD Anderson Cancer Center, Houston, TX)
"New therapy strategies for pancreatic cancer" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Endothelial receptor signaling and Angiogenesis |
| 7:30 pm - 7:40 pm | Discussion Leader: Rakesh Jain (Massachusetts General Hospital, Boston, MA)
"Introduction" |
| 7:40 pm - 8:00 pm | Chenghua Gu (Harvard Medical School, Boston)
"Developmental cross-talk between nervous and vascular systems" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:20 pm | Jessica Reinardy (Duke University, Durham, NC)
Short Talk selected from abstracts: "The role of Akt-mediated phosphorylation of Tie1 on endothelial gene expression"
|
| 8:20 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:45 pm | Lena Cleasson-Welch (Uppsala University, Uppsala, Sweden)
"VEGF signaling at endothelial junctions"
|
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:05 pm | Polena Helena (France)
Short Talk selected from abstracts: "Targeted therapies in renal cell carcinoma: effects on VE-Cadherin tyrosine phosphorylation and cleavage"
|
| 9:05 pm - 9:15 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Developmental Angiogenesis, Remodeling and Adaptation |
| 9:00 am - 9:15 am | Discussion Leader: Michael Simons (Yale University, New Haven, CT)
"Introduction" |
| 9:15 am - 9:35 am | Holger Gerhardt (Cancer Research UK, London, UK)
"Branch or expand? Pattern generation in vascular networks"
|
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Xuri Li (Sun Yat-Sen University, China)
Short Talk selected from abstracts: "Proliferative and survival effects of PUMA promotes angiogenesis" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:40 am | Sarah De Val (University of Oxford, Oxford, UK)
Short Talk selected from abstracts: "SoxF and notch directly control arterial identify through combined gene activation"
|
| 10:40 am - 10:45 am | Discussion |
| 10:45 am - 10:55 am | Stefania Nicoli (Yale University, New Haven, CT)
Short Talk selected from abstracts: "miRNA in angiogenesis regulation"
|
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Anne Eichmann (Yale University, New Haven, CT)
"Guidance of vascular patterning" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Ralf Adams (Max Planck Institute for Molecular Biomedicine, Muenster, Germany)
"Control of blood vessel remodeling and stability"
|
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Richard Lang (Cincinnati Children's Hospital, Cincinnati, OH)
"Regulation of vascular development in the eye by a light response pathway"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Immune System and Angiogenesis |
| Discussion Leader: Gabriele Bergers (UCSF, San Francisco, CA) |
| 7:30 pm - 7:50 pm | Max Mazzone (VIB, Leuven, Belgium)
"Macrophages in hypoxic tumor niches: should they stay or should they go?"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | James P. Allison (MD Anderson Cancer Center, Houston, TX)
"Tumor immunity and checkpoint blockade"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Michele De Palma (EPFL, Lausanne)
"Targeting angiogenesis in the inflammatory tumor microenvironment" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Gabriele Bergers (UCSF, San Francisco, CA)
"Pleiothrophic implications of innate immune cells in tumor progression and resistance"
|
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Endothelial and Vascular Tissue Heterogeneity |
| Discussion Leader: Rong Wang (UCSF, San Francisco, CA) |
| 9:00 am - 9:20 am | David Cheresh (UCSD, San Diego, CA)
"MicroRNA regulated pathways in angiogenesis and disease"
|
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Bjorn Olsen (Harvard Dental School, Boston, MA)
"The twist and turns of infantile hemangiomas" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:40 am | Mariona Graupera (IDIBELL, Barcelona, Spain)
Short Talk selected from abstracts: "Dynamic PTEN levels are key to develop blood vessels"
|
| 10:40 am - 10:45 am | Discussion |
| 10:45 am - 10:55 am | Michael Potente (Institute of Cardiovascular Regeneration, Frankfurt, Germany)
Short Talk selected from abstracts: "Linking angiogenesis and metabolism through FOXO transcription factors" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Valerie Weaver (UCSF, San Francisco, CA)
"Tissue tension reprograms the tissue to metastasis"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | John Condeelis (Albert Einstein College of Medicine, New York, NY)
"TMEM, a neo-vascular structure involved in tumor cell dissemination"
|
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Shahin Rafii (Weill Cornell Medical College, New York, NY)
"Molecular determinants of vascular angiocrine heterogeneity in organ maintenance and regeneration"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | Vascular Biology and Endothelial Plasticity and Mechanisms of Angiogenesis |
| 7:30 pm - 7:40 pm | Discussion Leader: Eli Keshet (The Hebrew University of Jerusalem, Jerusalem, Israel)
"Introduction" |
| 7:40 pm - 8:00 pm | Renata Pasqualini and Wadih Arap (MD Anderson Cancer Center, Houston, TX)
"Ligand-directed vascular targeting in translational medicine" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:20 pm | Masataka Majima (Kitasato University School of Medicine, Japan)
Short Talk selected from abstracts: "Microsomal prostaglandin E synthase-1 as a regulator of angiogenesis"
|
| 8:20 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:35 pm | Wiebke Herzog (Max Planck Institute for Molecular Biomedicine, Meunster, Germany)
Short Talk selected from abstracts: "Lumen ensheathment: novel developmental principles of vessel formation in the zebrafish"
|
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:00 pm | Elisabetta Dejana (IFOM-IEO, Milan, Italy)
"Endothelial to mesenchymal transition contributes to the development of cerebral cavernous malformations" |
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:30 pm | General Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mechanics and Mechanisms of Angiogenesis Inhibitors |
| 9:00 am - 9:10 am | Discussion Leader: Donald McDonald (UCSF, San Francisco, CA)
"Introduction"
|
| 9:10 am - 9:20 am | Douglas Hanahan (ISREC, Lausanne, Switzerland)
"Mechanisms of adaptive/evasive resistance to anti-angiogenic therapy"
|
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Napoleone Ferrara (UCSD, San Diego, CA)
"Role of the microenvironment in tumor angiogenesis" |
| 9:45 am - 9:55 am | Discussion |
| 9:55 am - 10:30 am | Coffee Break |
| 10:30 am - 10:40 am | Andrew Reynolds (Institute of Cancer Research, London, UK)
Short Talk selected from abstracts: "Vascular co-option in liver metastases mediates resistance to VEGF-targeted therapy"
|
| 10:40 am - 10:45 am | Discussion |
| 10:45 am - 10:55 am | Akiyoshi Uemura (Kobe University, Japan)
Short Talk selected from abstracts: "RhoJ defines endothelial cell motility by integrating VEGF and Sema3E signals"
|
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Hellmut Augustin (University of Heidelberg, Heidelberg, Germany)
"Angiocrine signaling and adjuvant tumor therapy: Role of ang/tie system" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | John Heymach (MD Anderson Cancer Center, Houston, TX)
"Biomarkers of angiogenesis inhibitors"
|
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Inder Verma (Salk Institute, La Jolla, CA)
"Functional endothelial vasculature derived from gliomas"
|
| 12:10 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Clinical Translation of Angiogenesis Knowledge |
| Discussion Leader: Malin Sund (Umea University, Umea, Sweden) |
| 7:30 pm - 7:45 pm | Laura Benjamin (ImClone/Eli Lilly, New York, NY)
"Emerging therapeutics for cancer"
|
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Chad May (Pfizer, New York, NY)
"Targeting the tumor vasculature with antibody drug conjugates" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Gavin Thurston (Regeneron Pharmaceuticals, Tarrytown, NY)
"Anti-angiogenesis therapy: where do we go from here?" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Padmanee Sharma (MD Anderson Cancer Center, Houston, TX)
"Immuno therapy clinical trials in cancer"
|
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Isaiah J. Fidler (MD Anderson Cancer Center, Houston, TX)
"Targeting astrocytes for therapy of brain tumors and (brain) metastasis"
|
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:30 pm | General Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
