Cardiac Regulatory Mechanisms
The Gordon Research Conference on “Cardiac Regulatory Mechanisms” began in 1982 and was held again in 1984, 1986, and 1989 on the general topic of “Cardiac Inotropic Agents”. This meeting provided a forum for discussion of the effects of inotropic agents on cardiac contractility and electrophysiology. The early meetings stimulated research that lead to much of our current understanding of the mechanisms of action of cardiac glycosides as well as to defining the relationships between ion transport by the Na/K pump and the Na/Ca exchanger and their specific contributions to cardiac inotropy in the normal and diseased heart. With advances in molecular biology, protein characterization, and state of the art methods for electrophysiological and biophysical characterization of cardiac cells, a new organizing committee was elected at the 1989 meeting and charged to broaden the goals and scope of the conference. It was proposed that the name and focus of the meeting be changed to “Cardiac Regulatory Mechanisms” with emphasis placed on discussion of specific molecular mechanisms regulating cardiac function. Since then, discussion has been balanced between those molecules that directly determine the functional properties of the heart (rate, rhythm and contractility) and signaling molecules that control myocyte growth and hypertrophy. The 1992-2000 meetings focused on discreet mechanisms regulating cardiac function that covered membrane and myofilament proteins, transcriptional and translational regulation, and hypertrophy and heart failure. In 2002, 2004, and 2006, these themes were continued with the introduction of new topics including the use of proteomics and genomics to explore the normal and diseased heart and sex-based differences in cardiac function. Biochemists, biophysicists, cell and molecular biologists, pharmacologists, physiologists and physician/scientists have attended these highly successful meetings.
What is a GRC? Gordon Research Conferences (GRC) are 5-day meetings that bring scientists together from around the world to present and discuss unpublished research with other leaders in their field.
This Gordon Research Conference (GRC) series is related to the "Cardiac Regulatory Mechanisms" Gordon Research Seminar (GRS)
series. Although a related GRS will typically be scheduled in conjunction with its parent GRC each time it meets, that may not always be the case. Refer to the individual meetings in the Meeting History
section below for more details. For more information about the associated Gordon Research Seminar (GRS) series, click here
.What is a GRS? Gordon Research Seminars (GRS) are 2-day meetings that bring graduate students and post-docs together to discuss their cutting edge research among peers and mentors. Each GRS immediately precedes an associated Gordon Research Conference (GRC), and topics addressed at the GRS relate closely to the GRC.