Proteolytic Enzymes & Their Inhibitors
Proteases play key roles in virtually every aspect of cell biology and every function of multicellular organisms. They are essential in such fundamental cell processes as separation of chromosomes during mitosis, cell-cycle control, apoptosis, and signal transduction. At the organismal level, these enzymes control such processes as wound healing, antigen presentation, reproduction, and neo-vascularization. Disregulation of proteases leads to or exacerbates an array of human pathologies including arthritis, stroke, dementia, metabolic disorders, blood coagulation defects, and cardiomyopathy. And infectious agents utilize proteases to mount their attacks.
This Gordon Research Conference traditionally deals with the structure, function, and regulation of these enzymes and, increasingly, with their physiological roles. There are typically also some talks on developments in techniques, such as mass spec identification of substrates and imaging proteolytic activity at the cell and whole-organism level. Areas of physiology usually covered include inflammation and immunology, cancer, cell death, and infectious disease, with additional areas varying from year-to-year. There is always a session on synthetic inhibitors, generally covering compounds going into the clinic. The conference is attended by biochemists, synthetic chemists, crystallographers, kineticists, experts in mass spectrometry, investigators of new biological imaging techniques, biologists and protein chemists.
What is a GRC? Gordon Research Conferences (GRC) are 5-day meetings that bring scientists together from around the world to present and discuss unpublished research with other leaders in their field.
This Gordon Research Conference (GRC) series is related to the "Proteolytic Enzymes & Their Inhibitors" Gordon Research Seminar (GRS)
series. Although a related GRS will typically be scheduled in conjunction with its parent GRC each time it meets, that may not always be the case. Refer to the individual meetings in the Meeting History
section below for more details. For more information about the associated Gordon Research Seminar (GRS) series, click here
.What is a GRS? Gordon Research Seminars (GRS) are 2-day meetings that bring graduate students and post-docs together to discuss their cutting edge research among peers and mentors. Each GRS immediately precedes an associated Gordon Research Conference (GRC), and topics addressed at the GRS relate closely to the GRC.