Protein Processing, Trafficking & Secretion
This conference series, initiated in 1994 by Drs. Michel Chrétien and Donald Steiner, was originally called “Hormonal and Neural Peptide Biosynthesis”. It has since grown into a major international forum for the discussion of new research developments related to the post-translational processing, trafficking and secretion of bioactive peptides and other secretory pathway proteins, as well as the significance of these processes to human disease and cellular physiology. These include protein folding events in the endoplasmic reticulum; all post-translational processing steps including structural, biochemical and cellular analyses of endo- and exoproteolysis and N- and C-terminal modifications; intra-Golgi and post-Golgi sorting events; mechanisms of vesicle formation and trafficking; and molecular mechanisms of regulated and constitutive secretion. Studies on the implications of defective processing for physiology and disease, as well as the development of animal models and silencing techniques for various protein/enzyme targets are some of the main attractions of this meeting. An additional important focus is on emerging functions of processing enzymes, including intramembrane proteolysis, and the associated pathologies whose underlying basis relates to protein processing and/or cellular trafficking. Thus, the meeting addresses core translational biology issues of importance to various pathologies and to the development of novel therapeutics. These include childhood diseases, neuroendocrine disorders such as diabetes, and neurodegenerative diseases such as Alzheimer's disease, dyslipidemias such as hypercholesterolemia and atherosclerosis, chronic pain, hypertension, viral glycoprotein and microbial maturation, cancer/metastasis, and many others.
What is a GRC? Gordon Research Conferences (GRC) are 5-day meetings that bring scientists together from around the world to present and discuss unpublished research with other leaders in their field.
This Gordon Research Conference (GRC) series is related to the "Protein Processing, Trafficking & Secretion" Gordon Research Seminar (GRS)
series. Although a related GRS will typically be scheduled in conjunction with its parent GRC each time it meets, that may not always be the case. Refer to the individual meetings in the Meeting History
section below for more details. For more information about the associated Gordon Research Seminar (GRS) series, click here
.What is a GRS? Gordon Research Seminars (GRS) are 2-day meetings that bring graduate students and post-docs together to discuss their cutting edge research among peers and mentors. Each GRS immediately precedes an associated Gordon Research Conference (GRC), and topics addressed at the GRS relate closely to the GRC.