Cartilage Biology & Pathology
Cartilage has two general roles: On the one hand, cartilage is a permanent tissue of outstanding biomechanical properties in the adult organism, providing joints with elasticity and high mechanical stability and ensuring mobility. On the other hand, cartilage has evolved in evolution as a transient tissue, shaping a model of the skeleton. Osteoarthritis (OA) and other degenerative joint diseases are not an inevitable fate coming with age. Several decades of research have shown ample evidence for genetic predisposition and for environmental or occupational risk for developing osteoarthritis. Nevertheless, there is still insufficient progress in understanding the pathogenesis of OA, including mechanisms of cartilage destruction and joint remodeling. With the recognition that degeneration and remodeling events in OA cartilage reflect changes in differentiation, gene expression and metabolic activities of the articular chondrocyte, the biology of this cell type has been moving to the center of research focus.
Strong evidence shows that the molecular mechanisms responsible for the pathogenesis of arthritic diseases are very similar to mechanisms regulating chondrocyte differentiation, maturation and endochondral ossification in skeletal development. This overlap of regulatory phenomena was a major rationale for the Gordon Conferences on cartilage biology. These conferences on cartilage biology bring together, for the first time, the fields of skeletal development, biochemistry, biomechanics, cell- and molecular biology of cartilage with the fields of cartilage pathology, human genetics of skeletal disorders, orthopedic research and tissue engineering.
What is a GRC? Gordon Research Conferences (GRC) are 5-day meetings that bring scientists together from around the world to present and discuss unpublished research with other leaders in their field.
This Gordon Research Conference (GRC) series is related to the "Cartilage Biology & Pathology" Gordon Research Seminar (GRS)
series. Although a related GRS will typically be scheduled in conjunction with its parent GRC each time it meets, that may not always be the case. Refer to the individual meetings in the Meeting History
section below for more details. For more information about the associated Gordon Research Seminar (GRS) series, click here
.What is a GRS? Gordon Research Seminars (GRS) are 2-day meetings that bring graduate students and post-docs together to discuss their cutting edge research among peers and mentors. Each GRS immediately precedes an associated Gordon Research Conference (GRC), and topics addressed at the GRS relate closely to the GRC.