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Vitamin B12 & Corphins
Gordon Research Conference

Conference Information

Status

Inactive

Initial Year

2003

Discipline

Chemical

Categories

Meeting Cycle

24 Months

Conference Description

The B12 field has a rich scientific history that culminated in 3 Nobel Prizes on its discovery, crystallographic characterization, and total synthesis. Because of its highly complex architecture (B12 is Nature’s largest and most complex cofactor) and its unique metal-carbon bond, B12 and its derivatives methyl- and adenosylcobalamin (MeCbl & AdoCbl) have attracted interests from a very broad community including biochemists, microbiologists, and chemists. Furthermore, the cofactor plays an important role in medicine. It was discovered during the search for the causes of pernicious anemia, and methylmalonic aciduria and homocystinuria are inborn errors of vitamin B12 metabolism. In addition, B12 nutritional deficiencies in the elderly are linked to dementia. Corphins are related in structure to the corrin ligand system in B12 and are found in the F430 cofactor involved in methane biosynthesis.

The GRC on B12 and corphins is highly interdisciplinary and is attended by scientists from a diverse array of fields including microbiology, biochemistry, chemistry, enzymology, epidemiology, genetics, medicine, and physics. Topics typically covered range from enzyme mechanisms, detailed spectroscopic studies on the cofactors, synthetic and computational model studies, and biosynthesis to toxicological studies, genetic markers for B12 metabolism, and the mechanisms of transport and metabolism.

What is a GRC? Gordon Research Conferences (GRC) are 5-day meetings that bring scientists together from around the world to present and discuss unpublished research with other leaders in their field.

Meeting History

YearMeeting NameDatesConference SiteChair(s)
2009 Vitamin B12 & Corphins
Organometallic Magic of Life on Earth: From Microorganisms to Humans
Aug 2-7 Magdalen College Bernhard Krautler
2007 Vitamin B12 & Corphins Jul 1-6 University of New England Wilfred A. van der Donk
2005 Vitamin B12 & Corphins Sep 18-23 The Queen's College Bernard Golding
2003 Cobalamin Jul 6-11 Colby College Ruma Banerjee
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