Thiol-Based Redox Regulation & Signaling
It was in 2004 that Vadim Gladyshev
and Ruma Banerjee
started thinking about organizing a GRC on Thiol-based Redox Regulation and Signaling
. By then, it had become increasingly clear that the reactive oxygen species are not only harmful to cells (oxidative stress), but serve key roles in signaling, by modulating the redox state of cysteines in key regulatory proteins, such as phosphatases and transcription factors. The sources of oxidative power necessary to form disulfide bonds in secretory proteins (oxidative protein folding) had been identified, and the number of physiological and pathological processes in which redox regulation and thiol chemistry played key roles was growing steadily. The first Conference, in 2006, gathered many investigators dealing with various aspects of thiol chemistry, signaling and pathophysiology. Its great impact and success prompted the organization of a second Conference on these issues, which saw a wealth of emerging concepts and technologies being thoroughly discussed. Also the second conference was sold out and greatly appreciated by the attendees. Even the most skeptical ones now agree that our understanding of cell physiology and pathology will be limited without taking in consideration the regulatory roles of thiol-based pathways. Novel ‘redoxomic’ technologies are pinpointing new elements in the integrated signaling pathways that drive the life of our cells and their organization in tissues and organs. Also exciting are the novel therapeutic approaches that are stemming from the understanding of these basic mechanisms.
What is a GRC? Gordon Research Conferences (GRC) are 5-day meetings that bring scientists together from around the world to present and discuss unpublished research with other leaders in their field.
This Gordon Research Conference (GRC) series is related to the "Thiol-Based Redox Regulation & Signaling" Gordon Research Seminar (GRS)
series. Although a related GRS will typically be scheduled in conjunction with its parent GRC each time it meets, that may not always be the case. Refer to the individual meetings in the Meeting History
section below for more details. For more information about the associated Gordon Research Seminar (GRS) series, click here
.What is a GRS? Gordon Research Seminars (GRS) are 2-day meetings that bring graduate students and post-docs together to discuss their cutting edge research among peers and mentors. Each GRS immediately precedes an associated Gordon Research Conference (GRC), and topics addressed at the GRS relate closely to the GRC.