Gordon Research Conferences
Conference Details

Thiol-Based Redox Regulation & Signaling
Gordon Research Conference

Conference Information



Initial Year





Meeting Cycle

24 Months

Conference Description

It was in 2004 that Vadim Gladyshev and Ruma Banerjee started thinking about organizing a GRC on Thiol-based Redox Regulation and Signaling. By then, it had become increasingly clear that the reactive oxygen species are not only harmful to cells (oxidative stress), but serve key roles in signaling, by modulating the redox state of cysteines in key regulatory proteins, such as phosphatases and transcription factors. The sources of oxidative power necessary to form disulfide bonds in secretory proteins (oxidative protein folding) had been identified, and the number of physiological and pathological processes in which redox regulation and thiol chemistry played key roles was growing steadily. The first Conference, in 2006, gathered many investigators dealing with various aspects of thiol chemistry, signaling and pathophysiology. Its great impact and success prompted the organization of a second Conference on these issues, which saw a wealth of emerging concepts and technologies being thoroughly discussed. Also the second conference was sold out and greatly appreciated by the attendees. Even the most skeptical ones now agree that our understanding of cell physiology and pathology will be limited without taking in consideration the regulatory roles of thiol-based pathways. Novel ‘redoxomic’ technologies are pinpointing new elements in the integrated signaling pathways that drive the life of our cells and their organization in tissues and organs. Also exciting are the novel therapeutic approaches that are stemming from the understanding of these basic mechanisms.

What is a GRC? Gordon Research Conferences (GRC) are 5-day meetings that bring scientists together from around the world to present and discuss unpublished research with other leaders in their field.

Related Conference

This Gordon Research Conference (GRC) series is related to the "Thiol-Based Redox Regulation & Signaling" Gordon Research Seminar (GRS) series. Although a related GRS will typically be scheduled in conjunction with its parent GRC each time it meets, that may not always be the case. Refer to the individual meetings in the Meeting History section below for more details. For more information about the associated Gordon Research Seminar (GRS) series, click here.

What is a GRS? Gordon Research Seminars (GRS) are 2-day meetings that bring graduate students and post-docs together to discuss their cutting edge research among peers and mentors. Each GRS immediately precedes an associated Gordon Research Conference (GRC), and topics addressed at the GRS relate closely to the GRC.

Meeting History

YearMeeting NameDatesConference SiteChair(s)
2018 Thiol-Based Redox Regulation & Signaling
Mechanisms and Organizing Principles in Redox Signal Propagation and Protein Redox Regulation
Jul 15-20 Rey Don Jaime Grand Hotel Tobias Dick
2016 Thiol-Based Redox Regulation & Signaling
Thiols in Biology and Medicine: Innovations Driving Disease Prevention, Therapeutics and Quality of Life
Aug 7-12 Stoweflake Conference Center Cristina M. Furdui
2014 Thiol-Based Redox Regulation & Signaling
From Redox Biology and Chemistry to Aging and Associated Diseases
Jul 20-25 PGA Catalunya Business and Convention Centre Michel B. Toledano
2012 Thiol-Based Redox Regulation & Signaling
The Molecular Underpinnings of Redox Regulation and Oxidative Stress
Jul 29 - Aug 3 Bates College Leslie B. Poole
2010 Thiol-Based Redox Regulation & Signaling May 9-14 Renaissance Tuscany Il Ciocco Roberto Sitia
2008 Thiol-Based Redox Regulation & Signaling May 25-30 Renaissance Tuscany Il Ciocco Ruma Banerjee
2006 Thiol-Based Redox Regulation & Signaling Jun 18-23 University of New England Vadim N. Gladyshev
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