Intrinsically Disordered Proteins
The Gordon Research Conference on Intrinsically Disordered Proteins (IDPs) was initiated in 2010 and granted continuing status by the GRC in 2012. The conference developed out of a recognized need in the community of investigators studying IDPs to have a venue where the latest results and ideas could be discussed. The impetus for a GRC on IDPs came out of discussions between Keith Dunker and Peter Tompa at the first FEBS conference on IDPs, which was organized by Peter Tompa in the spring of 2007 in Budapest Hungary. Following these discussions, Keith Dunker and Vladimir Uversky organized the first GRC on IDPs. Dunker, Tompa, and Uversky were three of the initial investigators to recognize the biological significance of protein disorder so it was fitting that they were involved in organizing some the first international conferences on IDPs.
While the general focus of the GRC on IDPs is on a particular structural class of proteins the sessions tend to cover a broad range of topics in the fields of computational, structural, evolutionary, molecular, systems and cell biology. Participants generally represent many of the major sub-disciplines in physics, chemistry, and biology and the presentations and discussions range from topics such as the conformational fluctuations of single molecules to the regulation of complex biological systems. Biophysicists and Computational Biologists attend the conference because they recognize the challenge that IDPs pose for structural biology and are keen to develop and explore new techniques to understand the structure and dynamics of IDPs. Biochemists and Molecular Biologists attend the conference because IDPs are often central players in important events that govern cellular fate and they tend to be hotspots for post-translational modifications and/or protein-protein interactions.
Even though the recognition of protein disorder as a genuine biological phenomenon was identified over 20 years ago, there are still a number of investigators who are not sure what to do when they discover their favorite protein is disordered. The GRC on IDPs is a venue where these investigators can come to learn about the latest research on the structure, function, and evolution of IDPs and make contacts with investigators from multiple disciplines that are usually familiar with the comment "you must have denatured the protein during purification".
What is a GRC? Gordon Research Conferences (GRC) are 5-day meetings that bring scientists together from around the world to present and discuss unpublished research with other leaders in their field.
This Gordon Research Conference (GRC) series is related to the "Intrinsically Disordered Proteins" Gordon Research Seminar (GRS)
series. Although a related GRS will typically be scheduled in conjunction with its parent GRC each time it meets, that may not always be the case. Refer to the individual meetings in the Meeting History
section below for more details. For more information about the associated Gordon Research Seminar (GRS) series, click here
.What is a GRS? Gordon Research Seminars (GRS) are 2-day meetings that bring graduate students and post-docs together to discuss their cutting edge research among peers and mentors. Each GRS immediately precedes an associated Gordon Research Conference (GRC), and topics addressed at the GRS relate closely to the GRC.