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Reprogramming Cell Fate
Gordon Research Conference

Conference Information

Status

Inactive

Initial Year

2012

Discipline

Biological

Categories

Meeting Cycle

24 Months

Conference Description

The Gordon Conference on "Reprogramming Cell Fate" will present cutting-edge research on the molecular and cellular aspects of reprogramming to pluripotency and lineage conversion and applications of reprogrammed cells. Somatic cell nuclear transfer (or cloning) showed that somatic nuclei can be reprogrammed to a primitive state to generate new embryos. Many groups focus on the mechanisms by which the donor nucleus is reprogrammed in the recipient ovum to understand pluripotency. Recently, it was shown that forced expression of key transcription factors that are important for maintaining pluripotent stem cells can cause somatic cells to be reprogrammed to a pluripotent state. Now known as induced pluripotency, this method has tremendous potential to be applied for patient-specific stem cell therapies and disease studies and thus garners extraordinary attention. More recently, several groups have shown that expression of various combinations of transcription factors can reprogram somatic cells directly to alternative somatic fates directly, without passing through a pluripotent intermediate. In the future, it will be important to reveal opportunities and limits of each of these reprogramming processes. Before any of these methods are applied in clinical settings, it is vital that the basic issues surrounding these various types of reprogrammed cells are settled. As these newly reprogrammed cells have only recently been generated, relatively little is known about their origins, their epigenetic state, their differentiation potential etc. This conference therefore is an ideal setting for discourse on not only mechanisms of reprogramming, but a detailed examination of reprogrammed cells, their developmental and functional potential, and the relevance of reprogramming to natural phenomena, and their clinical potential.

The 2012 conference will be the first Gordon Conference on this topic. The Conference will bring together a collection of investigators who are at the forefront of the field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. A collegial atmosphere, with defined discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, will provide an avenue for scientists from different disciplines to brainstorm and promote cross-disciplinary collaborations in the various research areas represented.

What is a GRC? Gordon Research Conferences (GRC) are 5-day meetings that bring scientists together from around the world to present and discuss unpublished research with other leaders in their field.

Meeting History

YearMeeting NameDatesConference SiteChair(s)
2014 Reprogramming Cell Fate
Understanding the Mechanisms of Nuclear Reprogramming and Its Potential in Cell Therapy
Mar 2-7 Hotel Galvez Konrad Hochedlinger
2012 Reprogramming Cell Fate Feb 26 - Mar 2 Hotel Galvez Kathrin Plath
William Lowry
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