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Drug Safety
Gordon Research Conference

Conference Information

Status

New

Initial Year

2014

Discipline

Biological

Categories

Meeting Cycle

24 Months

Conference Description

This new Gordon Research Conference is designed to stimulate discussion of contemporary approaches to assessing drug safety by researchers in academia, Pharma/Biotech, and regulatory agencies. We are particularly interested in new technologies, modeling, and examples of translational drug safety that can bridge the divides that exists between pre-clinical and clinical drug safety research, as well as that between clinical development and post-approval drug safety. Important benefits of this conference include the blend of expertise from the molecular to the epidemiological, of innovations from the laboratory to the clinic, and of researchers from academia, industry, and regulatory agencies.

Scientific sessions are sequenced in a way that parallels the drug development process itself, building momentum from the molecular to the epidemiological over the course of the week, as follows:

  • Chemical Biology and Systems Toxicology: Key topics include computational modeling and knowledge management approaches to leveraging the growing wealth of information in the public domain for early safety assessments of drug targets, pathways, and the compounds that modulate them.
  • Stem Cell and 3D Biology In Vitro: Focus is on system validation and applications of primary cells, stem cells, and 3D cell culture (microphysiologic) models including their utility in exploring toxicities that occur at the tissue level in animals and humans.
  • Animal Models and the Future of Drug Safety Testing: Key topics include the value of animal models, and applications of preclinical and clinical biomarkers of human toxicities, with focus on target organs including heart, liver, kidney, CNS, and hematology.
  • Human Safety in Development and Post-Approval: Focus is on application of novel biomarkers of drug toxicity, detection of drug safety events in late-phase development, and recognition of emerging drug safety issues post-approval.

Talks and robust discussions that explore both basic and applied research questions include the following: What are the most important drug safety issues for which we need additional research and technologies? What technological approaches have been effective, for what applications, which have been less successful, and why? For which drug safety issues are animals successful predictors of human drug safety issues, and for which are they inadequate? Are human stem cells superior nonclinical models for predicting human drug safety, for which types of toxicity, and why? What are the risk factors that predispose humans to adverse drug reactions? What do we currently know, and what do we suspect, are the contributions of genetic polymorphisms to drug safety issues in humans? How could this knowledge improve the design of clinical trials and guide the safe use of marketed compounds?

What is a GRC? Gordon Research Conferences (GRC) are 5-day meetings that bring scientists together from around the world to present and discuss unpublished research with other leaders in their field.

Related Conference

This Gordon Research Conference (GRC) series is related to the "Drug Safety" Gordon Research Seminar (GRS) series. Although a related GRS will typically be scheduled in conjunction with its parent GRC each time it meets, that may not always be the case. Refer to the individual meetings in the Meeting History section below for more details. For more information about the associated Gordon Research Seminar (GRS) series, click here.

What is a GRS? Gordon Research Seminars (GRS) are 2-day meetings that bring graduate students and post-docs together to discuss their cutting edge research among peers and mentors. Each GRS immediately precedes an associated Gordon Research Conference (GRC), and topics addressed at the GRS relate closely to the GRC.

Meeting History

YearMeeting NameDatesConference SiteChair(s)
2018 Drug Safety Jun 10-15 Stonehill College James L. Stevens
2016 Drug Safety
Improving Drug Safety: From Innovation in the Lab to Application in the Clinic
Jun 26 - Jul 1 Stonehill College Thomas Schroeter
2014 Drug Safety
Bridging the Divide Between Pre-Clinical and Clinical Drug Safety
Jun 1-6 Stonehill College David E. Watson
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