SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Lectures: Mechanisms of DNA Synthesis and Repair |
| Discussion Leader: Jessica Downs (University of Sussex) |
7:40 pm - 8:20 pm | Samuel Wilson (NIEHS/NIH)
"Structural Insight in Base Excision Repair" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Josef Jiricny (University of Zurich)
"The Mismatch Repair Interactome" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Endogenous Damage and Cell Signalling |
| Discussion Leader: Penny Jeggo (University of Sussex) |
9:00 am - 9:20 am | Penny Jeggo (University of Sussex)
"The benefit of relaxation: how ATM achieves it" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Duaa Mohammad (MIT)
"DNA damage signaling pathways, chromatin structure, and post-transcriptional control of gene expression" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 10:50 am | John Tainer (Scripps/LBNL)
"Damage Recognition and Signaling by Mre11-Rad50-Nbs1-ATM and TFIIH-CAK Kinase Complexes Control Biological Outcomes of DNA Damage" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | John Rouse (MRC PPU, University of Dundee)
"Forks and molecular knives in DNA repair" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Cynthia McMurray (Lawrence Berkeley National Laboratory)
"ATP hydrolysis by Rad50 switches MRE11 from an endonuclease to an exonuclease" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Timothy Humphrey (University of Oxford)
"Suppressing Break-Induced Loss of Heterozygosity" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Cell Cycle Responses to Genotoxicity |
| Discussion Leader: Kevin Hiom (Dundee Cancer Centre, University of Dundee) |
5:30 pm - 5:50 pm | Kevin Hiom (Dundee Cancer Centre, University of Dundee)
"Understanding the contribution of BRCA1 to maintenance of genome stability" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Laurence Pearl (University of Sussex)
"Recognition and repair of DNA strand breaks" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Helle Ulrich (London Research Institute)
"Mechanistic analysis of ubiquitin-dependent DNA damage bypass" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Michael Resnick (NIEHS, NIH)
"Resection and coordination at random double strand breaks" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Endogenous Damage and DNA Repair |
| Discussion Leader: Keith Caldecott (University of Sussex) |
9:00 am - 9:20 am | Keith Caldecott (University of Sussex)
"PARP3 is a novel component of mammalian DNA double strand break repair" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Ben van Houten (University of Pittsburgh)
"Alterations in mitochondrial dynamics affects cell cycle control and genome stability" |
9:50 am 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Aidan Doherty (University of Sussex)
"Orchestration of DNA Double-Strand Break Repair Processes by NHEJ Polymerases" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Dragony Fu (MIT)
"Mammalian AlkB dioxygenases: novel functions in the DNA damage response and cell death" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Susan Lees-Miller (University of Calgary)
"XLF interactions with XRCC4 create an extended grooved scaffold for DNA ligation and double-strand break repair" |
11:45 am - 11:50 pm | Discussion |
11:50 pm - 12:05 pm | Sherif El-Khamisy (University of Sussex)
"Breaking and sealing one strand of DNA: a role for SUMO" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Melanie Blasius (Gurdon Institute)
"The roles of the Chk1 kinase in the DNA-damage response and beyond" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Mutagenesis and Lesion Bypass - I |
| Discussion Leader: Alan Lehmann (University of Sussex) |
5:30 pm - 5:50 pm | Alan Lehmann (University of Sussex)
"Regulation of pol eta by post-translational modifications" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Julian Sale (MRC LMB)
"Structured DNA and epigenetic instability" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Robert Fuchs (CNRS, Marseille)
"The switches between replicative and TLS polymerases: an integrated view of Translesion Synthesis in E. coli" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Alba Guarne (McMaster University)
"Structural insights into the molecular mechanisms that regulate the endonuclease activity of MutL" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mutagenesis and Lesion Bypass - II |
| Discussion Leader: Tom Kunkel (NIEHS, NIH) |
9:00 am - 9:20 am | Tom Kunkel (NIEHS, NIH)
"Generating and Correcting Leading- and Lagging-Strand DNA Replication Errors in Yeast" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Roger Woodgate (NICHD, NIH)
"Properties of E. coli PolVMut" |
9:50 am 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Wei Yang (NIDDK, NIH)
"Molecular mechanism for DNA lesion recognition and repair" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Joann Sweasy (Yale University)
"Base Excision Repair Plymorphisms and Cancer" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Jeffrey Miller (UCLA)
"Finding mutators in Bacillus anthracis to discover the components of mismatch repair" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Nigel Savery (University of Bristol)
"Damage-detection during bacterial transcription coupled DNA repair" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Environmental and Genotoxic Stress |
| Discussion Leader: Laurence Loeb (University of Washington) |
5:30 pm - 5:50 pm | Lawrence Loeb (University of Washington)
"Human Cancers Express a Mutator Phenotype: Origin, Consequences and Targeting" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | David Phillips (ICR, UK)
"Complexities of cellular responses to genotoxicants" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Simon Reed (Cardiff University)
"An 'Omics' approach to measuring DNA damage and repair: from technique to translation" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Geoff Baldwin (Imperial College London)
"Network behavior in the BER system of the human pathogen Neisseria meningitidis" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chromatin Responses to Genotoxicity |
| Discussion Leader: Genevieve Almouzni (Institut Curie) |
9:00 am - 9:20 am | Genevieve Almouzni (Institut Curie)
"Variation on the theme of Chromatin Assembly" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Wim Vermeulen (Erasmus MC)
"responseIdentification of a novel transcription-coupled repair factor by an unbiased UV-induced ubiquitinome screen" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Michael Smerdon (Washington State University)
"Accessibility of DNA Lesions in Chromatin" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Zdenko Herceg (IARC)
"Role of histone acetylation in DNA damage response and chromatin-based processes" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Aaron Goodarzi (University of Calgary)
"ATM and PP4 control KAP-1 phosphorylation to form a molecular switch that regulates CHD3 nucleosome remodeling during the DNA double strand break response" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Alex Pines (Leiden University Medical Center)
"Recruitment of chromatin remodeling proteins at pre-incision stage of nucleotide excision repair by DDB2" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Replication and Links to Genotoxicity |
| Discussion Leader: Anthony Carr (University of Sussex) |
5:30 pm - 5:50 pm | Anthony Carr (University of Sussex)
"Analysis of recombination-mediated replication restart" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Marco Foiani (IFOM, Milan)
"The replication checkpoint protects fork stability by releasing topological tension at nuclear pore gated genes" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Steve Kowalczykowski (UC Davis)
"Mechanism of DNA-break repair: roles of BLM and BRCA2" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Katharina Schlacher (MSKCC)
"Replication fork protection provides a mechanistic link between breast cancer and Fanconi anemia susceptibility" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |