Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: How Diverse Interacting Systems Shape Epilepsies
Discussion Leader: Christophe Bernard (Inserm, France)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Annamaria Vezzani (Mario Negri Institute for Pharmacological Research, Italy)
"The Role of Neuroinflammation in Epilepsy: Mechanisms, Therapeutic Targets and Biomarkers"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Catherine Schevon (Columbia University Medical Center, United States)
"Dual Roles of Inhibition Shape the Network Behavior of Focal Seizures"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Dynamics of Synapses and Circuits in Epilepsies
Discussion Leader: Kevin Staley (Harvard Medical School, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Michelle Antoine (National Institute on Alcohol Abuse and Alcoholism , United States)
"Treating Epilepsy in Autism by Targeting Temperature-Modulated Potassium Channels"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Marco de Curtis (Fondazione Istituto Neurologico Carlo Besta, Italy)
"Interneuronal Activity, GABA and Potassium Changes at the Onset of a Focal Seizure"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Shreya Malhotra (Stanford University, United States)
"CCK Basket Cell Activity Deviates from the Network During Seizures in vivo "
10:30 am - 10:35 am
Discussion
10:35 am - 11:15 am
Group Photo / Coffee Break
11:15 am - 11:40 am
Linda Overstreet-Wadiche (University of Alabama at Birmingham, United States)
"Temporal Pattern Decorrelation in The Dentate Gyrus"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Michael Wenzel (Bonn University, Germany)
"Region-Specific Ictal Spreading Depression as a Key Epilepsy Disease Factor in Mice and Humans"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Sung-Soo Jang (Stanford University , United States)
"Impairment of Thalamic Reticular Nucleus contributes to ASD-related behaviors in the ASD model of CNTNAP2 KO"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Farah Lubin (University of Alabama at Birmingham, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Evolving Circuits During Development
Discussion Leader: Joaquin Lugo (Baylor University, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Lena Nguyen (University of Texas at Dallas, United States)
"Deciphering Mechanisms of Epileptogenesis in Developmental mTORopathies"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Vanesa Nieto Estevez (University of Texas at San Antonio, United States)
"Dual Effects of ARX Poly-Alanine Mutations in Human Cortical and Interneuron Development"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Ranmal Samarasinghe (University of California, Los Angeles, United States)
"Modeling Hippocampal Versus Cortical Neural Network Activity in a Human Brain Assembloid Model of Genetic Epilepsy"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Ciara Mc Mahon (University College Dublin, Ireland)
"Initial Growth and Characterization of CHD2-Patient Derived Cerebral Organoids"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Interplay Between Inflammation, Microglia and Astrocytes
Discussion Leader: Karen Wilcox (University of Utah, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Chris Dulla (Tufts University School of Medicine, United States)
"Astrocytes are "Excited" in the Seizing Brain"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Long-Jun Wu (Mayo Clinic, United States)
"Neuroimmune Interaction in Seizures and Epilepsy: Focusing on Microglial Calcium Signaling"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Olga Taraschenko (University of Nebraska Medical Center, United States)
"Mechanisms of Autoimmune Encephalitis and Residual Memory Loss"
10:30 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Devin Binder (University of California, Riverside, United States)
"Alterations in Astrocyte Water Channels and Glutamate Transporters During Epileptogenesis and Potential Translational Implications"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Chao Yan (Nanjing University, China)
"SCD1-High Microglia Promote Neuronal Excitation in Epilepsy Via the LPC-LPA-LPA2R Axis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ahmed Jamali (Kavli Institute for Systems Neuroscience / Norwegian University of Science and Technology, Norway)
"The Role of Astroglia-Neuron Interactions in Network Hyperexcitability and Seizures"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dynamics of the Cerebrovasculature and Associated Compartments
Discussion Leader: Daniela Kaufer (University of California, Berkeley, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Dirk Dietrich (Universitätsklinik Bonn, Germany)
"Blood-Brain-Barrier Leakiness in Temporal Lobe Epilepsy?"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Gordon Teskey (University of Calgary, Canada)
"Vascular, Metabolic and Endocrine Contributions to the Postictal State"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Roustem Khazipov (Institut de Neurobiologie de la Méditerranée, France)
"How Spreading Depolarizations Shape Epileptic Activity"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Dynamic Omics
Discussion Leader: Ingrid Scheffer (University of Melbourne, Australia)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Jeffrey Noebels (Baylor College of Medicine , United States)
"Glioblastomics: Spatial Transcription of Epilepsy Genes in Acquired Peritumoral Epileptogenesis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Pablo Casillas-Espinosa (Monash University, Australia)
"Multi-Omics Integration to Uncover the Molecule Signature of the Epilepsies"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Christina Gross (Cincinnati Children's Hospital Medical Center, United States)
"Sex-Related Differences in Epigenetic Regulation of the Brain: Implications for Hormonal Regulation of Seizure Susceptibility"
10:30 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Avtar Roopra (University of Wisconsin at Madison, United States)
"Graph Theory and Network Analysis of Transcriptomic Data: Identification of a Potent, Disease Modifying Agent to Enduringly Suppress Seizures and Restore Cognition"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Yang Yang (Purdue University, United States)
"SCN2A Related Seizures: From Mouse and iPSCs Models to Genetic Medicine"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Christa Habela (Johns Hopkins University School of Medicine, United States)
"Altered Neuronal Development and Network Connectivity in a Model of 15q11.2 Related Neurodevelopmental Disorders"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Interacting Systems: Energetics, Metabolism and Oxidative Stress
Discussion Leader: Manisha Patel (University of Colorado, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Mark Beenhakker (University of Virginia School of Medicine, United States)
"Metabolic Regulation of Spike-Wave Seizures"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Juan Pascual (Weill Cornell Medicine , United States)
"Inhibitory Neuron Failure in Metabolic Epilepsy"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Kristina Simeone (Creighton University School of Medicine, United States)
"Pathologic Role of The Metabolic Regulating Neuropeptide Orexin in Promoting SUDEP Risk by Engaging Multiple Networks"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Beyond Seizures
Discussion Leader: Jaideep Kapur (University of Virginia, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
George Richerson (University of Iowa, United States)
"Abnormal CO2 Interoception as a Biomarker and Risk Factor for SUDEP"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Sneham Tiwari (Boston Children's Hospital, United States)
"Early Death in DEPDC5 Loss of Function Mosaic Zebrafish Model"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Jamie Maguire (Tufts University School of Medicine, United States)
"Neuroendocrine Influences on Epilepsy: Beyond Seizures"
10:25 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Jorge Palop (Gladstone Institutes / University of California, San Francisco, United States)
"Defining PV Cell Dynamics During Gamma Oscillations in Health and Alzheimer’s Disease"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Maxime Baud (University of Bern, Switzerland)
"Timing of Seizure Risk"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Brian Lundstrom (Mayo Clinic, United States)
"Multiple Timescale Neural Adaptation as a Mechanism Underlying Seizure Onset Zone Excitability"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Computational Insights into Complex Systems
Discussion Leader: Sarah Muldoon (University of New York at Buffalo, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Sridevi Sarma (Johns Hopkins University, United States)
"Brain Entropy Index and its Applications to Measuring Efficacy of Seizure Suppression"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
William Stacey (University of Michigan, United States)
"High Frequency Oscillation Network Dynamics Predict Outcome in Non-Palliative Epilepsy Surgery"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Yujiang Wang (Newcastle University, United Kingdom)
"A Data Science Perspective on Human Epilepsy"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure