Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Harnessing the Power of Data to Guide Reaction Optimization
Discussion Leader: Spencer Pitre (Oklahoma State University, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Anat Milo (Ben-Gurion University of the Negev, Israel)
"Machine Learning Strategies for Secondary Sphere Modification in Organocatalysis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Veronique Gouverneur (University of Oxford, United Kingdom)
"Rethinking Fluorine Chemistry with Global Challenges in Mind"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Catalysis: New Tools and Applications
Discussion Leader: Liela Romero (Baylor University, United States)
9:00 am - 9:30 am
David Leitch (University of Victoria, Canada)
"New Tools for Organopalladium Catalysis in High-Throughput Experimentation and Beyond"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Sharon Neufeldt (Montana State University, United States)
"Controlling Site Selectivity in Pd-Catalyzed Cross-Couplings"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Ted Judd (Amgen, United States)
"Development and Execution of an Early Phase-Enabling Process for Manufacturing AMG 193 for Phase I Studies"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Seth Herzon (Yale University, United States)
"Synthesis of Securines and Securamines"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Gregg Barcan (GSK, United States)
"Asymmetric Preparation of a Chiral Benzothiazepine API"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Evgeniya Semenova (AbbVie, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Organic Synthesis
Discussion Leader: Curtis Rieder (Gilead Sciences, Canada)
7:30 pm - 8:00 pm
Jeff Bandar (Colorado State University, United States)
"New Base-Promoted Oxidative and Reductive Coupling Reactions"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Michael Sherburn (Australian National University, Australia)
"New Hydrocarbons as Lynchpins in Step Economic Total Synthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Brenda Burke (Sanofi, United States)
"Leveraging Mechanistic Studies and Kinetic Modeling of Impurity Formation to Fuel Optimization of a Commercial Process Towards a BTK Inhibitor"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Applications-Driven Catalysis
Discussion Leader: Courtney Roberts (University of Minnesota, United States)
9:00 am - 9:30 am
Yu Zhao (National University of Singapore, Singapore)
"Enantioconvergent Redox-Neutral Functionalization of Alcohols via Borrowing Hydrogen Catalysis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Sidney Wilkerson-Hill (The University of North Carolina at Chapel Hill, United States)
"Strained Molecule Synthesis Using Palladium Carbenes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Michael Hilinski (University of Virginia, United States)
"New Directions in Iminium Organocatalysis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Yi Hsiao (AsymChem, China)
"Development of Continuous Manufacturing Process for the Pharmaceutical Industry: the Challenges and Applications"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Kotaro Iwasaki (Chugai Pharmaceutical Co., Ltd. (Roche Group), Japan)
"A Chemoselective Removal of Boc and tBu Groups within Highly N-Alkylated Peptides: An Enabling Technology in the Process Development of "Mid-Sized" Drugs"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metal Catalysis
Discussion Leader: Tiffany Piou (Merck Process R&D, United States)
7:30 pm - 8:00 pm
Sophie Rousseaux (University of Toronto, Canada)
"New Strategies for the Synthesis and Functionalization of Small Rings"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Dean Tantillo (University of California, Davis, United States)
"Is My Low Yield the Result of a Post-Transition State Bifurcation?"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
David Thaisrivongs (Merck, United States)
"The Largest Small Molecule: How Chemistry Enabled the Discovery and Development of PCSK9 Inhibitor MK-0616"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Adventures in Synthesis, Catalysis, and Reaction Discovery
Discussion Leader: Graham Murphy (University of Waterloo, Canada)
9:00 am - 9:30 am
Jeffrey Gustafson (San Diego State University, United States)
"Atropisomerism as an Inspiration for New Chemistry"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Santanu Mukherjee (Indian Institute of Science, Bangalore, India)
"Breaking Symmetry: Development & Application to Complex Targets"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Jianrong Zhou (Peking University Shenzhen Graduate School, China)
"Asymmetric Reductive Addition of Organic Halides to Polar Double Bonds"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Michael Williams (BMS, United States)
"Building Seamless Capabilities with HTE, Automation and Data Architectures"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Trevor Johnson (Denali Therapeutics, United States)
"Regioselective Strategies for Manufacturing a pPyrimidine Aminopyrazole Compound"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Informatics and Methods
Discussion Leader: Shauna Paradine (University of Rochester, United States)
7:30 pm - 8:00 pm
Marvin Parasram (New York University, United States)
"Anaerobic Heteroatom Transfer Reactions Promoted by Photoexcited 1,3-Diploles"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Cristina Nevado (University of Zurich, Switzerland)
"A Radical Approach to Asymmetric Synthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Philipp Roosen (Pfizer, United States)
"Process Development of the NextGen Covid Therapeutic PF-07817883"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Unique Bond-Forming Reactions
Discussion Leader: Kimberly Petersen (University of North Carolina at Greensboro, United States)
9:00 am - 9:30 am
Stephen Newman (University of Ottawa, Canada)
"Deoxygenative Cross-Coupling Reactions"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Tanja Gaich (University of Konstanz, Germany)
"Natural Product Synthesis and Synthetic Methodology"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Visible Light Photoredox Catalysis
Discussion Leader: Jon Tunge (The University of Kansas, United States)
7:30 pm - 8:00 pm
Patricia Musacchio (Worcester Polytechnic Institute, United States)
"A Redesigned Approach to Accessing Carbocations"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Tristan Lambert (Cornell University, United States)
"Electrophotocatalysis: Combining Light and Electricity to Promote Reactions"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
David MacMillan (Princeton University, United States)
"New Photocatalytic Reactions that will be (Hopefully) Useful to Pharmaceutical Discovery"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure