Sunday PM
Session 1: Designing protein-protein interactions
- Session Chair: Tracy Handel, The University of California, Berkeley
Session introduction
- Charles Craik, The University of California, San Francisco
"Combinatorial Redesign of Serine Protease Macromolecular Inhibitors"
- Homme Hellinga, Duke University
"Design of proteins for biosensing applications"
- Steven Mayo, Caltech
"Reverse engineering of protein structures and interactions"
Monday AM
Session 2: Engineering out aggregation in formulations
- Session Chair: James Lee, The University of Texas, Galveston
Session introduction
- George Somero, Stanford University
"Protein stability: co-evolution of sequence and the internal milieu"
- Serge N. Timasheff, Brandeis University
"Mechanism of biological reaction modulation by osmolytes"
- Wayne Bolen, The University of Texas, Galveston
"Organic Osmolytes of Environmentally Stressed Organisms: Natural Selection of Cell Solvent"
- John F. Carpenter, The University of Colorado Health Sciences Center
"Thermodynamic Inhibition of Irreversible Protein Precipitation and Amyloid Fibril Formation"
Monday PM
Session 3: Linked binding energetics
- Session Chair: Gary Ackers, Washington University School of Medicine
Session introduction
- Madeline Shea, University of Iowa College of Medicine
"Conformational Switching & Domain Crosstalk in Calmodulin"
- Gregory Reinhart, Texas A & M University
"Asymmetric Couplings in a Symmetric Tetramer"
- Austen Riggs, The University of Texas, Austin
"Application of light scattering to the assembly of hemoglobins"
Tuesday AM
Session 4: Protein nucleic acid interactions
- Session Chair: Pete von Hippel, The University of Oregon
Session introduction
- Arthur E. Johnson, Texas A&M Health Sciences Center
"GTP-dependence of Signal Recognition Particle Binding to Ribosome-bound Signal Sequences"
- David E. Draper, The Johns Hopkins University
"Protein recognition of RNA tertiary structure in the ribosome"
- David Lilley, The University of Dundee
"Protein-protein and protein-DNA interactions that ensure the productive resolution of Holliday junctions by resolving enzymes"
- Stephen Kowalczykowski, The University of California, Davis
"Interactions with proteins and DNA during translocation by DNA helicases"
Tuesday PM
Session 5: Protein-membrane interactions
- Session Chair: Karen G. Fleming, Yale University
Session introduction
- Nancy L. Thompson, The University of North Carolina
"Coupled reaction and transport at membrane surfaces: Measurement by total internal reflection fluorescence microscopy"
- Gordon Tollin, The University of Arizona
"Plasmon Resonance Spectroscopy: Applications to Proteolipid Membranes"
- Stephen H. White, The University of California, Irvine
"The energetics of folding proteins into membranes"
Wednesday AM
Session 6: Kinetics and thermodynamics of biomolecular
assemblies
- Session Chair: Kenneth P. Murphy, The University of Iowa
Session introduction
- Michael Doyle, SmithKline Beecham, Inc.
"Binding Thermodynamics of Human CD4 and HIV gp120: A Molecular Switch for Viral Invasion"
- K. Dane Wittrup, MIT
"Antibody maturation to femtomolar affinity by directed evolution"
- Jack Kirsch, The University of California, Berkeley
"Complementary Mutations in the Epitope and Paratope of the Lysozyme/HyHel10 Complex, and The Delineation of Docking Trajectories"
- David Myszka, The University of Utah
"Pushing SPR Biosensors to the Limit"
Wednesday PM
Session 7: Interactions in blood coagulation
- Session Chair: Kenneth G. Mann, The University of Vermont
Session introduction
- Michael N. Blackburn, SmithKline Beecham, Inc.
"Coagulation enzyme-inhibitor interactions and novel therapeutic approaches"
- Gary L. Nelsestuen, The University of Minnesota
"Membrane association by proteins with high calcium stoichiometry. Vitamin K-dependent, pentraxins and annexins"
- Sriram Krishnaswamy, Joseph Stokes Research Institute
"Macromolecular Substrate Recognition in Blood Coagulation"
Thursday AM
Session 8: Mass spectroscopy of interacting systems
- Session Chair: Steven Carr, SmithKline Beecham, Inc.
Session introduction
- Brian Chait, Rockefeller University
"Mass Spectrometric Approaches for Elucidating Protein Interactions"
- Ken Standing, The University of Manitoba
"Study of Biomolecular Systems by Time-of-Flight Mass Spectrometry"
- Carol Robinson, Oxford University
"Disassembly of intact multiprotein complexes in the gas phase"
- Bruce Goode, The University of California, Berkeley
"Mass spectrometry dissection of the cellular actin machine"
Thursday PM
Session 9: Protein-small molecule interactions
- Session Chair: David Myszka, The University of Utah
Session introduction
- Steve Fesik, Abbott Laboratory
"Insights into protein/small molecule interactions from NMR"
- Victor Hruby, University of Arizona
"Plasmon resonance spectroscopy: Applications to proteolipid membranes"
- Dan Erlanson, Sunesis Pharmaceuticals, Inc.
"Binding at protein interfaces: big to small"
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