SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Recognition and Reactions at the Cell Surface |
7:30 pm - 7:45 pm | Discussion Leader: Michelle R. Arkin (Sunesis Pharmaceuticals) |
7:45 pm - 8:20 pm | Mark Davis (Howard Hughes Medical Institute) "Ligand Binding at the Immunological Synapse" |
8:20 pm - 8:55 pm | Timothy Springer (Harvard Medical School) "Inside Out Signaling in Integrins, from the Cytoplasm to the Extracellular Ligand Binding Domains" |
8:55 pm - 9:30 pm | Deborah Leckband (University of Illinois) "Novel Mechanisms in Cell Adhesion" |
9:30 pm | Poster Session / Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Transition States, Specificity and Design in Protein Recognition |
9:00 am - 9:10 am | Discussion Leader: Colin Kleanthous (University of York) |
9:10 am - 9:50 am | Gideon Schreiber (Weizmann Institute of Science) "Deciphering the Pathway of Protein-Protein Association and Its Application Towards Protein Design" |
9:50 am - 10:30 am | Colin Kleanthous (University of York) "Specificity in High Affinity Systems" |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:40 am | Dan S. Tawfik (The Weizmann Institute of Science) "Conformational Diversity and Protein Evolution" |
11:40 am - 12:20 pm | David Baker (University of Washington) "Prediction and Design of Protein-Protein Interactions" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session / Refreshments |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Molecular Simulations of Biomolecular Associations |
7:30 pm - 7:45 pm | Discussion Leader: Adrian H. Elcock (University of Iowa) |
7:45 pm - 8:20 pm | Brian K. Shoichet (University of California, San Francisco) "Model Systems for Docking and Scoring" |
8:20 pm - 8:55 pm | Alan E. Mark (University of Groningen) "Simulating Self-Organization in (Bio)Molecular Systems" |
8:55 pm - 9:30 pm | Carlos J. Camacho (Boston University) "From Molecular Recognition to Docking: A Guide to Predicting Protein Interactions" |
9:30 pm | Poster Session / Refreshments |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Assembly of Macromolecular Complexes Involving Nucleic Acid |
9:00 am - 9:10 am | Discussion Leader: James Cole (University of Connecticut) |
9:10 am - 9:50 am | Timothy Lohman (Washington University School of Medicine) "Helicase-Catalyzed DNA Unwinding" |
9:50 am - 10:30 am | Kiyoshi Mizuuchi (NIDDK, National Institutes of Health) "Assembly and Disassembly Dynamics of Protein-DNA Complexes Involved in Phage Mu Transposition: Studies at the Single Molecule Level" |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:40 am | Jeffrey C. Hansen (Colorado State University) "Protein-Mediated Assembly of Novel, Higher-Order Chromatin Structures in vitro" |
11:40 am - 12:20 pm | Victoria DeRose (Texas A&M University) "Metals, Folding and Catalysis in Ribozymes" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / tour and wine tasting at Wyatt Technologies |
4:00 pm - 6:00 pm | Poster Session / Refreshments |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Natively Unfolded Proteins and their Role in Molecular Recognition |
7:30 pm - 7:45 pm | Discussion Leader: Joel L. Sussman (Weizmann Institute of Science) |
7:45 pm - 8:20 pm | Tony Fink (University of California Santa Cruz) "Conformational Mobility of -Synuclein: A Natively Unfolded Protein" |
8:20 pm - 8:55 pm | James Shorter (Whitehead Institute for Biomedical Research) "Modulation of Yeast Prion Behavior by the AAA+ Protein Hsp104" |
8:55 pm - 9:30 pm | Reinhard Jahn (Max Planck Institute for Biophysical Chemistry) "Conformational Cycle of SNARE Proteins and Its Role in SNARE-Mediated Membrane Fusion" |
9:30 pm | Poster Session / Refreshments |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | What Will Proteomics Miss: Weak, Small and Complex |
9:00 am - 9:10 am | Discussion Leader: David G. Myszka (University of Utah) |
9:10 am - 9:50 am | Rebecca Rich (University of Utah) "Easy Come, Easy Go" |
9:50 am - 10:30 am | Virginia L. Rath (Thios Pharmaceuticals) "Characterizing Allosteric Drugs by SPR" |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:40 am | Savitha Devanathan (University of Arizona) "Give Me a G, Give Me a P, Give Me a C, Give Me an R…What's It Spell?" |
11:40 am - 12:20 pm | Scott Klakamp (Abgenix, Inc.) "How Long Must I Wait?" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / whale watching, through Ventura shuttle |
4:00 pm - 6:00 pm | Poster Session / Refreshments |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Signal Integration by Protein Phosphorylation |
7:30 pm - 7:45 pm | Discussion Leader: Susan S. Taylor (University of California San Diego) |
7:45 pm - 8:20 pm | Mark A. Lemmon (University of Pennsylvania School of Medicine) "An Open-and-Shut-Case? Activation of Epidermal Growth Factor Receptor by
Ligand-Induced Release of Auto-Inhibitory Interactions" |
8:20 pm - 8:55 pm | Sharon Campbell (University of North Carolina) "Structure and Dynamic Studies of the Focal Adhesion Targeting Domain of
Focal Adhesion Kinase (FAK): Regulation of Phosphorylation and Paxillin Binding" |
8:55 pm - 9:30 pm | Jin Zhang (Johns Hopkins University School of Medicine) "Dynamic Visualization of Kinase/Phosphatase Activities in Living Cells" |
9:30 pm | Poster Session / Refreshments |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Discovery of Drugs that Disrupt Protein Interactions |
9:00 am - 9:10 am | Discussion Leader: Ernesto Freire (The Johns Hopkins University) |
9:10 am - 9:50 am | Ernesto Freire (The Johns Hopkins University) "Different Strategies to Disrupt Protein/Protein Interactions: Competitive and Allosteric Inhibitors" |
9:50 am - 10:30 am | Jean Chmielewski (Purdue University) "Small Molecule Inhibitors of Protein-Protein Interactions: HIV Proteins" |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:40 am | Irwin Chaiken (Drexel University College of Medicine) "Differentiating Recognition and Activation in Designing Antagonists of Receptor Machines" |
11:40 am - 12:20 pm | Andrea Cochran (Genentech, Inc.) "Peptide-Based Strategies to Inhibit Protein-Protein Interactions" |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Special "Poster" Session: Selected Student Oral Presentations |
| Poster Judges: TBA |
| Six, ten minute talks with five minutes of questions from student based on poster judging |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Emerging Technologies for Studying Molecular Interactions |
7:30 pm - 7:45 pm | Discussion Leader: Thomas Laue (University of New Hampshire) |
7:45 pm - 8:20 pm | Zygmunt Gryczynski (University of Maryland) "Surface Plasmon Coupled Emission - New Technology for Studying Biomolecular Processes" |
8:20 pm - 8:55 pm | Allen P. Minton (National Institutes of Health) "Tracer Sedimentation Equilibrium: the "Swiss Army Knife" of Analytical Ultracentrifugation" |
8:55 pm - 9:30 pm | Terrence G. Oas (Duke University Medical Center) "Protein Stability and Ligand Binding Measurements Using MS-Detected Amide Hydrogen Exchange in Living Cells and Crude Mixtures" |
9:30 pm | Poster Session / Refreshments |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |