SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Single-Molecule Dynamics |
7:35 pm - 7:45 pm | Discussion Leader: Justin Molloy (MRC Nat'l Inst. for Medical Research) |
7:45 pm - 8:10 pm | Taekjip Ha (Univ. Illinois - Urbana-Champaign)
"Playing Extreme Sports with Single Biological Molecules" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Nynke Dekker (TU Delft)
"From Single Molecules to the Cell" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | David Colquhoun (University College London)
"Single ion channels; stochastic theory, experimental results and structure-activity predictions" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session / Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Protein Fluctuation and Function |
9:00 am - 9:15 am | Discussion Leader: Ruth Nussinov (NCI, Tel Aviv University) |
9:15 am - 9:40 am | Michele Vendruscolo (University of Cambridge)
"Simultaneous Determination of Protein Structure and Dynamics" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Shohei Koide (Univ of Chicago)
"Minimalist requirements for protein interaction interfaces defined from synthetic single-domain binding proteins" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Charalampos Kalodimos (Rutgers University)
"Protein Dynamics and Allostery" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Lila Gierasch (Univ. of Mass. Amherst)
"Moving the Protein Folding Problem from the Test Tube to the Cell" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Josh Wand (University of Pennsylvania)
"The role of conformational entropy in molecular recognition by proteins" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session / Refreshments |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Protein-Drug Dynamics |
7:30 pm - 7:45 pm | Discussion Leader: Jeffery Kelly (Scripps Research Institute) |
7:45 pm - 8:10 pm | Dennis Wolan (UCSF)
"Small Molecule Activators of Effector Caspases" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Jason Gestwicki (University of Michigan)
"Allosteric Regulation of Hsp70 by Small Molecules" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Irwin Chaiken (Drexel University)
"Antagonizing Protein Switches: Recent Investigations on HIV-1 Cell Entry and Beta c Cytokines" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session / Refreshments |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Advances in Physical Methods |
9:00 am - 9:15 am | Discussion Leader: Linda Nicholson (Cornell University) |
9:15 am - 9:40 am | Elizabeth Komives (Univ. of Calif. - San Diego)
"Folding and Binding in the NF-kB/IkB Interaction" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Muhammad Zaman (Univ of Texas at Austin)
"Characterizing the free energy landscape of receptor-ligand interactions in cell adhesion" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | John Christodoulou (University College, London / Birkbeck College, London)
"Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Mattia Rocco (Instituto Nazionale per la Ricerca sul Cancro)
"Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multi-resolution approach" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | Brian Chait (Rockefeller Institute)
"Proteomic Approaches for Analyzing Complex Biological Machines" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session / Refreshments |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Conformational Heterogeneity and Natively Disordered Proteins |
7:30 pm - 7:45 pm | Discussion Leader: Peter Tompa (Hungarian Academy of Sciences) |
7:45 pm - 8:10 pm | Richard Kriwacki (St. Jude's Research Hospital)
"Flexibility and Modularity in Signaling Mediated by IUPs" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Sonia Longhi (Universités d'Aix-Marseille)
"Measles virus N and P proteins as a model system for the study of structural disorder and induced folding" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Vladimir Uversky (Indiana University School of Medicine)
"Intrinsically Disordered Proteins as Interactors and Drug Targets" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session / Refreshments |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Enzyme Dynamics |
9:00 am - 9:15 am | Discussion Leader: Steve Benkovic (Pennsylvania State Univ.) |
9:15 am - 9:40 am | Sharon Hammes Schiffer (Pennsylvania State Univ.)
"Hydrogen Tunneling and Protein Motion in Enzyme Reactions" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Juliet A Gerrard (Univ of Canterbury)
"Evolution of quaternary structure in a homotetrameric protein" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Rama Ranganathan (Univ. Texas, Southwestern Medical Center)
"Evolutionary Design of Proteins" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | John Chaput (Arizona State Univ)
"Progress Towards the Evolution of Tailor-made Catalysts" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | Vern Schramm (Albert Einstein College of Medicine)
"Protein Architecture and Transition State Structure in Purine Nucleoside Phosphorylase" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session / Refreshments |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Protein Network Dynamics |
7:30 pm - 7:45 pm | Discussion Leader: Stephen Michnick (Universite de Montreal) |
7:45 pm - 8:10 pm | Andre Levchenko (Johns Hopkins University)
"Investigating Signaling Networks Using Microfabricated Devices" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Klaus Hahn (UNC-Chapel Hill)
"Subsecond and submicron coordination of signaling events in living cells - dynamics of Rho GTPase networks" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Dev Sidhu (Genentech)
"Evolution of Natural and Synthetic PDZ Domain Networks" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session / Refreshments |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Macromolecular Machines and Assemblages |
9:00 am - 9:15 am | Discussion Leader: Jeff Hansen (Colorado State Univ.) |
9:15 am - 9:40 am | Craig Peterson (Univ. of Massachusettes)
"Chromatin remodeling machines" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Nicholas Housden (Univ of York)
"An intrinsically disordered protein goes potholing; how colicins recruit the porin OmpF in the E. coli outer membrane" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | P. John Hart (Univ. of Texas Health Science Center)
"Allosteric motions NAD+-specific isocitrate dehydrogenase" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Yakov Kipnis (Weizmann Institute of Science)
"Linking allostery in the chaperonin GroEL to protein folding" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | Jack Correia (Univ. of Mississippi Medical Center)
"Energetics, Regulation and Modeling of Mitotic Microtubule Complexes" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Address |
7:30 pm - 7:40 pm | Discussion Leader: Michelle Arkin (UCSF) |
7:40 pm - 8:40 pm | David Baker (Univ. of Washington)
"Design of New Protein Interactions and Catalytic Activities" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm | Closing Party |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |