| SUNDAY |
| 7:30 | Introduction and orientation |
| Structural/Conformational Studies on DNA lesions |
| 8:00 | Introduction: Nicholas Geacintov, New York University |
| 8:10 | Monique Cosman, Lawrence Livermore National
Laboratories
"Solution Structure of the 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-C8-dG Adduct Opposite dC in a DNA Duplex" |
| 8:50 | Jane Sayer , N.I.H.
Polycyclic aromatic hydrocarbons as probes of enzyme mechanisms |
| 9:30 | Final Discussion: Nicholas Geacintov, New York
University |
| MONDAY |
| | Lesion Mutagenesis |
| 9:00 | Introduction: John Essigmann, M.I.T. |
| 9:10 | John Essigmann, M.I.T.
"Mutagenic specificity of secondary DNA lesions derived from oxidized purines." |
| 9:50 | Robert Fuchs, Centre National de la Recherche
Scientifique
"Trafficking of DNA polymerases during translesion synthesis" |
| 10:30 | Break (and photograph) |
| 10:50 | John Steven Taylor, Washington University
"Mechanistic Probes of Photoproduct Bypass by Replicative and DNA Damage Bypass Polymerases" |
| 11:30 | Zafri Humayun, New Jersey Medical School
SOS-independent inducible mutagenesis |
| 12:10 | Final Discussion: John Essigmann, M.I.T. |
| DNA polymerases I (structure/function) |
| 7:30 | Introduction: Samuel Wilson, NIEHS |
| 7:40 | Samuel Wilson, NIEHS
"Signaling Catalysis in the DNA Polymerase Ternary Complex" |
| 8:20 | Loreena Beese, Duke University
Observing DNA mispairs and carcinogenic lesions during DNA replication |
| 9:00 | Wei Yang, NIH
Structure of the Lesion-Bypass DNA Polymerase DinB |
| 9:40 | Final Discussion: Samuel Wilson, NIEHS |
| TUESDAY |
| DNA polymerases II (biological roles) |
| 9:00 | Introduction: Louise Prakash, University of Texas,
Galveston |
| 9:10 | Louise Prakash, University of Texas, Galveston
DNA damage bypass in eukaryotes |
| 9:50 | Satya Prakash, University of Texas, Galveston
DNA polymerase eta: structure and function |
| 10:30 | Break |
| 11:40 | Zvi Livneh, Weizmann Institute of Science
Mechanistic analysis of lesion bypass in E. coli and in mammals |
| 11:20 | Michael Christman, University of Virginia
Role of TRF4/Pol sigma in the DNA damage response |
| 12:00 | Final Discussion: Louise Prakash, University of
Texas, Galveston |
| DNA polymerases III (protein/DNA interactions, structure and function) |
| 7:30 | Introduction: Bea Singer, University of California, Berkeley |
| 7:40 | Bea Singer, University of California, Berkeley
The Role of DNA Sequence Context in Defining the Efficiency of DNA Repair |
| 8:20 | Roger Woodgate, NIH
Insights into the biological functions of mammalian DNA polymerase iota |
| 9:00 | Thomas Spratt, American Health Foundation
The Contacts Between a DNA Polymerase and DNA That Dictate Fidelity |
| 9:40 | Final Discussion: Bea Singer, University of California, Berkeley |
| WEDNESDAY |
| DNA repair (recombinational lesion avoidance mechanisms) |
| 9:00 | Introduction Michael Cox, University of Wisconsin |
| 9:10 | Michael Cox, University of Wisconsin
"The RecA protein and the repair of stalled replication forks" |
| 9:50 | Andre Kuzminov, University of Illinois
Chromosomal damage: predisposition, formation and repair |
| 10:30 | Break |
| 10:40 | Maki Moriya, SUNY, Stoney Brook
"Cellular response to endogenous DNA adducts" |
| 11:20 | Tanya Paull, University of Texas, Austin
"The Mre11/Rad50/Nbs1 complex and mechanisms of DNA double-strand break repair" |
| 12:00 | Final Discussion: Michael Cox, University of Wisconsin |
| Cellular responses to DNA damage I (late breaking matters) |
| 7:30 | Introduction: Larry Loeb, University of Washington |
| 7:40 | Larry Loeb, University of Washington
Multiple Mutations in Human Cancers: Evidence and Implications |
| 8:20 | Natalia Tretyakova, University of Minnesota
"Mapping nucleobase adducts within DNA sequences with electrospray and MALDI mass spectrometry" |
| 9:00 | Late breaking matters |
| 9:40 | Final Discussion: Larry Loeb, University of Washington |
| THURSDAY |
| | Cellular responses to DNA damage II (cell cycle effects) |
| 9:00 | Introduction: Cyrus Vaziri, Boston University
> Medical School |
| 9:10 | Cyrus Vaziri, Boston University Medical School
Molecular Mechanism of the Bulky Adduct-Induced S-Phase Checkpoint |
| 9:50 | Paul Nghiem, Harvard University
"ATR in the cell cycle of normal and cancer cells: An achilles heel for cancer?" |
| 10:30 | Break |
| 10:40 | Larry Karnitz, Mayo Foundation
"9-1-1: a life preserver for damaged DNA" |
| 11:20 | Beth Baber, The Salk Institute
The 3 R's of the DNA damage checkpoint: recognition, repair and arrest |
| 12:00 | Final Discussion: Cyrus Vaziri, Boston University
Medical School |
| Mutations in carcinogenesis |
| 7:30 | Introduction: Curtis Harris, National Cancer Institute |
| 7:40 | Curtis Harris, National Cancer Institute
"p53, nitric oxide and apoptosis" |
| 8:20 | Kyungjae Myung, University of California at San Diego
Genetic control of genome instability in Saccharomyces cerevisiae |
| 9:00 | Peter Jones, University of Southern California
"Silencing tumor suppressor genes by DNA Methylation" |
| 9:40 | Final Discussion: Curtis Harris, National Cancer
Institute |
