| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Clinical Presentation and Neuropathology of the Polyglutamine Disorders |
| Session Chair: Dr. Nancy Wexler (Columbia University, USA) |
| 7:30 pm - 8:15 pm | Dr. Alexandra Dürr (Hôpital de la Pitié Salpêtrière, Paris, France)
"Clinical and genetic features of polyglutamine disorders" |
| 8:15 pm - 9:00 pm | Dr. Bernhard Landwehrmeyer (University of Ulm, Germany)
"The neuropathology of the polyglutamine disorders" |
| 9.00 pm - 9.30 pm | Dr. Marie Françoise Chesselet (University of California, Los Angeles, USA)
Structured Discussion |
| 9.30 pm | Welcome reception and informal discussions |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | The Spinocerebellar Ataxias |
| Session Chair: Dr. Jenny Morton (University of Cambridge, UK) |
| 9:00 am - 9:45 am | Dr. Juan Botas (Baylor College of Medicine, USA)
"Mechanisms of pathogenesis: insights from Drosophila" |
| 9:45 am - 10:30 am | Dr. Al La Spada (University of Washington, USA)
"Understanding SCA7 polyglutamine neurodegeneration: models, mechanisms, and pathways" |
| 10:30 am | Coffee Break and Group Photo |
| 11:00 am - 11:45 am | Dr. Stephan Pulst (University of California, Los Angeles, USA)
"SCA2: from in vitro and mouse models to modifying alleles" |
| 11.45 am - 12.30 pm | Dr. Harry Orr (University of Minnesota, USA)
Structured Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session 1 |
| 5:30 pm - 7:30 pm | Molecular pathogenesis - Gain / Loss of Function |
| Session Chair: Dr. Lynn Raymond (University of British Columbia, Canada) |
| 5:30 pm - 6:15 pm | Dr. Elena Cattaneo (University of Milan, Italy)
"Dysfunction of huntingtin in Huntington's disease" |
| 6:15 pm - 7:00 pm | Dr. Gen Sobue (Nagoya University, Japan)
"SBMA, pathogenesis and therapy-insights from animal models" |
| 7.00 pm - 7.30 pm | Dr. Kurt Fischbeck (NINDS, NIH, USA)
Structured Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9.00 am - 10:45 am | Triplet Repeat Instability and the Non-Polyglutamine Repeat Diseases |
| Session Chair: Dr. David Housman (Massachusetts Institute of Technology, USA) |
| 9.00 am - 9:40 am | Dr. Virginia Zakian (Princeton University, USA)
"Effects of trinucleotide repeats on replication fork progression and chromosome fragility in yeast" |
| 9.40 am - 10.20 am | Dr. Laura Ranum (University of Minnesota, USA)
"Dominant non-coding expansion disorders: DM2 and SCA8" |
| 10.20 am - 10.45 am | Dr. Christopher Ross (Johns Hopkins University, USA)
Structured Discussion |
| 10:45 am | Coffee Break |
| 11:15 am - 12:30 pm | Polyglutamine Repeat Diseases - Neuronal Dysfunction and Degeneration |
| 11:15 am - 12:30 pm | Dr. Patrik Brundin (University of Lund, Sweden)
Structured Discussion and Poster Blitz Session |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session 2 |
| 5:30 pm - 7:30 pm | Cellular Mechanisms in the Nucleus and Cytoplasm |
| Session Chair: Dr. Jang Ho Cha (Massachusetts General Hospital, USA) |
| 5:30 pm - 6:15 pm | Dr. Pier Paolo Pandolfi (Memorial Sloan-Kettering Cancer Center, USA)
"PML and the Nuclear Body in apoptosis: a possible role in the pathogenesis of neurodegenerative disorders" |
| 6:15 pm - 7:00 pm | Dr. Ron Kopito (Stanford University, USA)
"The role of the ubiquitin-proteasome system in the pathogenesis of neurodegenerative disease" |
| 7.00 pm - 7.30 pm | Dr. Leslie Thompson (University of California, Irvine, USA)
Structured Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Model Systems and the Development of Therapeutic Compound Screens |
| Session Chair: Dr. Erich Wanker (Max Delbruck Center, Berlin, Germany) |
| 9:00 am - 9:45 am | Dr. Ron Wetzel (University of Tennessee, USA)
"The physical behavior of simple polyglutamine sequences and CAG repeat diseases; molecular mechanisms, diagnostics, and therapeutics" |
| 9:45 am - 10:30 am | Dr. Hank Paulson (University of Iowa, USA)
"Studies of MJD/SCA3: toward an understanding of mechanisms and novel therapeutics" |
| 10:30 am | Coffee Break |
| 11:00 am - 12:30 pm | Dr. James Gusella (Massachusetts General Hospital,
USA)
Structured Discussion and Poster Blitz Session |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session 3 |
| 5:30 pm - 7:30 pm | Late Breaking News |
| Session Chair: Dr. Cheryl Wellington (University of British Columbia, Canada) |
| 5:30 pm - 5:48 pm | Dr. Joan Steffan (University of California, Irvine, USA)
"Huntingtin is stabilized by SUMO-1 modification" |
| 5.48 pm - 6.06 pm | Dr. Hung-Kai Chen (Baylor College of Medicine, USA)
"Neurodegeneration in SCA1 is mediated by a class of phosphorylation-dependent ataxin-1 binding proteins" |
| 6.06 pm - 6.24 pm | Dr. Ali Khoshnan (Caltech, USA)
"Mutant huntingtin binds IKK? and activates the NF-?B pathway: implications for Huntington’s disease pathology" |
| 6.24 pm - 6.42 pm | Dr. Marjorie Ariano (Chicago Medical School, USA)
"NMDA receptor dysfunction in experimental models of Huntington's disease" |
| 6.42 pm - 7.00 pm | Dr. Peter Reinhart (Duke University, USA)
"Poly-proline domains in huntingtin influence Huntingtin aggregation and neurodegeneration" |
| 7.00 pm - 7.30 pm | Dr. Carl Johnson (Hereditary Disease Foundation, USA)
Structured Discussion |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Experimental Therapeutics and Biomarkers |
| Session Chair: Dr. Anne Young (Massachusett's General Hospital, USA) |
| 9:00 am - 9.45 am | Dr. Anne Young (for Diana Rosas) (Massachusett's General Hospital, USA)
"Evidence for more widespread cerebral pathology in early HD: an MRI based analysis" |
| 9:45 am - 10:30 am | Dr. Karen Marder (Columbia University, USA)
"Clinical Trials in HD: Study design and outcomes" |
| 10:30 am | Coffee Break |
| 11:00 am - 11.45 am | Dr. Bob Ferrante (Boston University School of Medicine, USA)
"Translational Therapeutics Using Transgenic HD Mice: Alternative Strategies From the Medicine Cabinet" |
| 11.45 am - 12:30 pm | Dr. Karl Kieburtz (University of Rochester, USA)
Structured Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:00 pm | Poster Viewing |
| 5.00 pm - 6:00 pm | Business Meeting |
| 6:00 pm - 7:30 pm | KEY NOTE LECTURE |
| Session Chair: Dr. Mike Levine (University of California, Los Angeles, USA) |
| 6.00 pm - 7:00 pm | Dr. Susan Lindquist (Whitehead Institute, Massachusett's
Institute of Technology, USA)
"Neurodegenerative Disease: Lessons from Yeast" |
| 7.00 pm - 7.30 pm | Discussion |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
