SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | An Introduction to Issues and Approaches Needed for a Comprehensive Understanding of Mechanosensing |
| Discussion Leaders: Gloria Muday (Wake Forest University) and Paul Blount (University of Texas Southwestern) |
7:40 pm - 8:10 pm | Ching Kung (University of WI, Madison) "Mechanosensitive-channel research: History, current status, and prospects" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Martin Chalfie (Columbia University, Biological Sciences, NY) "Genetic approaches to understanding mechanosensation in eukaryotes" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Michael Sheetz (Columbia University) "Mechanosensing through force and geometry effects on cytoskeletal protein conformation" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Genetic and Genomic Approaches to Mechanotransduction and Gravity Signaling I |
| Discussion Leader: Michael Gustin (Rice University) |
9:00 am - 9:35 am | Shawn Xu (University of Michigan) "TRP channels and mechanosensation in C. elegans" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:00 am | Roberto Araujo (Columbia University) "Can C. elegans Sense Gravity?" |
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:10 am | Gary Lewin (Max Delbruck Center for Molecular Medicine) "Stomatins and somatic mechanosensation in mice" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:55 am | Elizabeth Haswell (Washington University, St. Louis) "Genetic and Electrophysiological Analyses of MscS-Like Channels in the Arabidopsis Root" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Kenjiro Yoshimura (University of Tsukuba) "MSC1, a homolog of MscS, expressed in the intracellular membrane of Chlamydomonas" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Biochemical and Biophysical Mechanisms of Mechanosensory systems |
| Discussion Leader: Miriam Goodman (Stanford University) |
7:30 pm - 8:00 pm | Boris Martinac (The University of Queensland, Australia) "3.5 billion years of mechanosensory transduction: lessons from studies of prokaryotic mechanosensitive channels (MscL, MscS)" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Peter F. Davies (University of Pennsylvania) "Endothelial cell phenotypes of swine arteries and heart valves map to mechanosensitive locations in vivo" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Martin Guthold (Wake Forest University) "A combined atomic force/fluorescence microscopy technique to probe the viscoelastic properties of fibrin fibers" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Specialized Mechano- or Gravity-Sensitive Cells or Tissues |
| Discussion Leader: Ruth Anne Eatock (Harvard University) |
9:00 am - 9:15 am | Guenther Leitz (University of Colorado) "Statolith Sedimentation Kinetics and Force Transduction to the Cortical Endoplasmic Reticulum in Gravity-sensing Arabidopsis Columella Cells" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:50 am | SPECIAL PRESENTATION: Owen Hamill (University of Texas Medical Branch) and Fred Sachs (State University of New York, Buffalo) Each will speak for 15 minutes "Troubleshooting guide for studying TRP channel mechanosensitivity (or, for the Star Trek fans: Troubles with TRPs)"
|
9:50 am - 10:05am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:10 am | Roger Hangarter (Indiana University) "Analysis of the gravitropic set point angle in Arabidopsis" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:55 am | Ardem Patapoutian (Scripps Research Institute) "Trpa1 and mechanosensation" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Max Lab (Imperial College) "Non-Invasive mechanical interrogation of living cells using pressureand a scanning ion conductance probe" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Ionic Signaling During Mechanosensory Transduction |
| Discussion Leader: Fred Sachs (State University of New York, Buffalo) |
7:30 pm - 8:05 pm | Gaby Monshausen (University of Wisconsin) "Mechanotransduction in plants, from Ca++ and ROS to cell elongation" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:50 pm | Helen Kennedy (University of Bristol, UK) "Mechano-electrical Transduction in the Mammalian Auditory System" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Armagan Koçer (Biomade Technology Foundation) "Activating a mechanosensitive channel, MscL, in the absence of tension" |
9:15 pm - 9:25 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cellular and Tissue Responses to Mechanical Stimuli or Gravity |
| Discussion Leader: Stan Roux (University of Texas, Austin) |
9:00 am - 9:35 am | John Robinson (Wyeth Research) "Activation of Wnt signaling is a normal physiological response to mechanical loading in bone" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:00 am | Brad Akitake (University of Maryland College Park) "Straightening and sequential buckling of the pore-lining helices define the gating cycle of the stretch-activated channel MscS" |
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 10:50 am | Patrick Masson (University of WI, Madison) "A novel class of microtubule-binding proteins that control thigmomorphogenesis, root growth behavior and anisotropic cell expansion in Arabidopsis" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:10 am | Maria Lia Molas (Miami University) "Spaceflight experiments to investigate the interaction between gravitropism and phototropism in plants" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:55 am | Jeff Holt (University of Virginia School of Medicine) "The molecular mechanisms of adaptation in mechanosensory hair cells" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Stanley Roux (University of Texas, Austin) "Changes in Gravitational Stimuli Rapidly Alter the Magnitude and Direction of a Calcium Current in a Single Cell" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Role of Cytoplasmic and Extracellular Proteins in Mechanosensory Transduction |
| Discussion Leader: Viola Vogel (Swiss Federal Institute of Technology) |
7:30 pm - 8:05 pm | Benjamin Matthews (Harvard Medical School) "Mechanotransduction through integrins and stress-activated ion channels" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:50 pm | Benny Geiger (Weizmann Institute) "Mechanosensitive interactions in the integrin adhesome" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Suzanne Bechstedt (MPI-CBG) "EMAP- a microtubule associated protein important for mechanosensory transduction in Drosophila" |
9:15 pm - 9:25 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genetic and Genomic Approaches to Mechanotransduction and Gravity Signaling II |
| Discussion Leader: Patrick Masson (University of WI, Madison) |
9:00 am - 9:35 am | Kate Beckingham (Rice University) "Isolation of gravitaxis mutants of Drosophila" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:00 am | Hidetoshi Iida (Tokyo Gakugei University) "Characterization of Arabidopsis plasma membrane proteins, Mca1 and Mca2, involved in Ca2+ uptake and mechanosensing" |
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:10 am | Sarah Wyatt (Ohio University) "Identification of mutants with altered gravity signal transduction" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:55 am | Masao Tasada (Nara Institute of Science and Technology) "Genetic analysis of the signaling pathways in Arabidopsis shoot gravitropism" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Craig Cohen (Stony Brook Univ. Med. Ctr.) "CFTR-dependent Stretch Induced Differentiation of the Lung and Intestines" |
12:30 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Neuronal Responses to Mechanostimuli |
| Discussion Leader: Owen Hamill (University of Texas Medical Branch) |
7:30 pm - 8:05 pm | John Wood (University College, London) "Molecular basis of mammalian noxious mechanosensation" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:50 pm | Charles Bourque (McGill University and Montreal General Hospital) "Mechanotransduction in osmosensory neurons" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Richard Hwang (Duke University) "Nociceptive multidendritic neurons protect Drosophila larvae from parasitoid wasps" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |