SUNDAY |
| Advancing Quantitative Approaches for the Analysis of Macromolecular Interactions |
7:30 pm - 7:40 pm | Chair: Olwyn ByronUniversity of Glasgow, Scotland, UK |
7:45 pm - 8:15 pm | Dmitri Svergun, European Molecular Biology Laboratory, Germany SAXS/SANS to study shapes of molecules and complexes in solution. |
8:20 pm - 8:50 pm | Xiaoliang Sunney Xie, Harvard University, USA New Advances in Single-Molecule Enzymology and Coherent Anti-Stokes Raman Scattering (CARS) Microscopy of Living Cells |
8:55 pm - 9:25 pm | David G. Myszka, University of Utah School of Medicine, USA Advanced Applications of SPR Biosensors |
9:30 pm | Session Discussion |
MONDAY |
| Conformational Heterogeneity and Biological Function |
9:00 am - 9:10 am | Chair: Vincent J. Hilser, University of Texas Medical Branch, USA |
9:15 am - 9:55 am | Robert O. Fox, University of Texas Medical Branch, USA Engineering Miniprotein Protein Ligands by Sculpting the Conformational Ensemble. |
10:00 am - 10:25 am | Coffee Break |
10:30 am - 11:00 am | Josh Wand, University of Pennsylvania, USA Dynamic activation of protein function |
11:05 am - 11:35 am | Wayne Bolen, University of Texas Medical Branch, USA Forcing Intrinsically Unstructured Proteins to Fold |
11:40 am - 12:10 pm | Linda K. Nicholson, Cornell University, USA When motion matters: Relationships between conformational flexibility and function in selected protein systems. |
12:15 am - 12:30 pm | Session Discussion |
| Structural Energetics of Protein-ligand Interactions |
7:30 pm - 7:40 pm | Chair: Kenneth P. Murphy, University of Iowa College of Medicine, USA |
7:45 pm - 8:15 pm | Ernesto Freire, Johns Hopkins University, USA A Thermodynamic Guide to Drug Design |
8:20 pm - 8:50 pm | Rafael Zubillaga Luna, Universidad Autónoma Metropolitana-Iztapalapa, México, D.F. Structural determinants of protein-carbohydrate affinities
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8:55 pm - 9:25 pm | Adrian H. Elcock, University of Iowa College of Medicine, USA Computer Simulations of Protein-protein Interactions |
9:30 pm | Session Discussion |
TUESDAY |
| Macromolecular Interactions Involving RNA |
9:00 am - 9:10 am | Chair: David Draper, Johns Hopkins University, USA |
9:15 am - 9:45 am | Vinod Misra , University of Michigan, USA A thermodynamic framework for ion binding and RNA folding |
9:50 am - 10:20 am | Phil Bevilacqua, Pennsylvania State University, USA Probing the Folding Pathway and Catalytic Mechanism of the Hepatitis Delta Virus Ribozyme |
10:20 am - 10:40 am | Coffee Break |
10:45 am - 11:15 am | Dr. Paul Gollnick, SUNY Buffalo, USA The Interaction Between the TRAP Protein and RNA: Genetics, Biochemistry and Structural Biology |
11:20 - 11:50 am | James R. Williamson, The Scripps Research Institute, USA 30S ribosome subunit: Some assembly required. |
11:55 am - 12:30 pm | Session Discussion |
| Energetics and kinetics for signaling |
7:30 pm - 7:40 pm | Chair: Elliot Ross, University of Texas Southwestern Medical Center, USA |
7:45 pm - 8:15 pm | Rama Ranganathan, University of Texas Southwestern Medical Center USA Mapping protein energetics onto protein structure |
8:20 pm - 8:50 pm | James E. Ferrell, Jr., Stanford University, USA Building a cell cycle oscillator: stability and sensitivity in Cdc2 activation |
8:55 pm - 9:25 pm | Stuart G. McLaughlin, SUNY at Stony Brook, USA Electrostatic interaction of proteins with membranes: the PIP2 connection. |
9:30 pm | Session Discussion |
WEDNESDAY |
| Studying Protein Dynamics in Living Cells |
9:00 am - 9:10 am | Chair: Jennifer Lippincott-Schwartz, NICHD/NIH, USA |
9:15 am - 9:45 am | Daniel Gerlich, German Cancer Research Center, Germany Global spatial order of chromosomes is inherited throughout mitosis. |
9:50 am - 10:20 am | Robert D. Phair, BioInformatics Services, USA
Kinetics of Protein Binding in Living Cells |
10:20 am - 10:40 am | Coffee Break |
10:45 am - 11:15 am | John Carson, University of Connecticut Health Center, USA RNA granule dynamics in oligodendrocytes and the Virtual Cell |
11:20 am - 11:50 am | Jennifer Lippincott-Schwartz, NICHD/NIH, USA Analysis of intracellular membrane trafficking pathways in living cells |
11:55 am - 12:30 pm | Session Discussion |
| Macromolecular crowding and confinement as driving forces for inter- and intra-molecular association |
7:30 pm - 7:40 pm | Chair: Allen Minton, NIDDK,NIH, USA |
7:45 pm - 8:15 pm | Danny Hatters, Department of Biochemistry and Molecular Biology,
University of Melbourne Acceleration of amyloid formation by macromolecular crowding |
8:20 pm - 8:50 pm | C.-C. Wang, Academia Sinica, China Effects of macromolecular crowding on the folding and assembly of proteins |
8:55 pm - 9:25 pm | Gary J. Pielak, University of North Carolina, USA Effects of crowder size on the structure and stability of proteins and protein complexes |
9:30 pm | Session Discussion |
THURSDAY |
| Proteomics - Global Discovery and Description of Molecular Interactions |
9:00 am - 9:10 am | Chair: Steve A Carr, Millennium Pharmaceuticals, Inc, USA |
9:15 am - 9:45 am | Raymond J. Deshaies, California Institute of Technology, USA Systematic identification of protein complexes and analysis of protein-protein interaction networks by mass spectrometry. |
9:50 am - 10:20 am | Huilin Zhou, Institute for Systems Biology, USA Quantitative proteomics: new technologies and their applications to protein phosphorylation. |
10:20 am - 10:40 am | Coffee Break |
10:45 am - 11:15 am | Jeff Ranish, Institute for Systems Biology, USA Analysis of macromolecular complexes by quantitative proteomics |
11:20 am - 11:50 am | Marian Walhout, Harvard Medical School, USA Dana-Farber Cancer Institute and Department of Genetics Protein interaction maps for the nematode C. elegans |
11:55 am - 12:30 pm | Session Discussion |
| Advances in first principle methods |
7:30 pm - 7:40 pm | Chair: Tom Laue, University of New Hampshire, USA |
7:45 pm - 8:15 pm | Jennifer Durant, University of New Hampshire, USA Membrane confined electrophoresis: what does it tell us? |
8:20 pm - 8:50 pm | Peter Schuck, National Institutes of Health, USA A new approach to the hydrodynamic characterization of protein mixtures |
8:55 pm - 9:25 pm | Mattia Rocco, Istituto Nazionale per la Ricerca sul Cancro, Italy Fibrin Assembly -- New Insights from time-resolved multiangle light scattering studies |
9:30 pm | Session Discussion |