SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | KEYNOTE SESSION: TOXICOGENOMICS - A TOOL TO PROBE DISEASE AND MECHANISMS OF TOXICITY |
| Discussion Leader: Cindy Afshari (Amgen) |
7:40 pm - 8:25 pm | Lois Lehman-McKeeman (Bristol-Myers Squibb)
"Chips and Dip: Food for Thought on Applying Toxicogenomics to Basic and Applied Toxicology Research" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | David Schwartz (NIEHS)
"Environmental Genomics and Human Health" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | IMPACT OF GENOMICS IN RESPIRATORY TOXICOLOGY |
| Discussion Leader: David Schwartz (NIEHS) |
9:00 am - 9:50 am | Naftalie Kaminski (Univ. Pittsburgh)
"The Genomics of Chronic Lung Injury and Fibrosis - A Systems Approach" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 11:20 am | George Leikauf (Univ. Cincinnati)
"Transcriptional Signature of Acute Lung Injury" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:20 pm | Katsuhide Igarashi (Natl. Inst. Of Health Sciences, Japan)
"Pulmonary Toxicogenomics as a part of multi-organ Percellome Project" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KIDNEY DISEASE AND NEPHROTOXICITY BIOMARKERS |
| Discussion Leader: Rick Paules (NIEHS) |
7:30 pm - 8:20 pm | Frank Staedtler (Novartis)
"Renal Safety Biomarkers in Drug Development" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | David Gerhold (Merck)
"Rat Kidney Biomarkers: Translation from RNAs to Proteins" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | VASCULAR TOXICITY, NETWORK BIOLOGY AND BIOMARKERS |
| Discussion Leader: Hisham Hamadeh (Amgen Inc.) |
9:00 am - 9:50 am | Ken Ramos (Univ. Louisville Health Sciences Center)
"Computational and biological inference of LINE-1 Regulatory Networks" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:20 am | Ken Wallace (Univ. Minnesota)
"Metabolomic Correlates of the Transcriptional Signature of Doxorubicin-induced Cardiomyopathy" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:20 pm | Mike Lawton (Pfizer, Inc.)
"A Systems Biology Approach to the Discovery of Candidate Biomarkers and Mechanisms of Drug-induced Vascular Injury in Rats and Dogs" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NETWORK ANALYSIS AND INTEGRATION |
| Discussion Leader: Ken Ramos (Univ. Louisville) |
7:30 pm - 8:20 pm | Yudong He (Rosetta / Merck)
"Uncovering Sufficiency Network for Compound-induced Effects in Animal Model via Expression Profiling" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Bernard Palsson (UCSD)
"Reconstruction and Uses of the Genome-Scale Reconstruction of the Human Metabolic Network" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | HEPATOTOXICITY AND GENOMICS EXPLORATION |
| Discussion Leader: Jim Stevens (Lilly) |
9:00 am - 9:50 am | Linda Griffith (MIT)
"Liver-Tissue Engineering Models for Toxicogenomics" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:20 am | Laura Suter-Dick (Roche)
"The Use of Toxicogenomics: Illustration with Case Examples" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:20 pm | Ivan Rusyn (UNC Chapel Hill)
"Genetical Genomics and Liver Toxicology: Making New Friends" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | HUMAN SUSCEPTIBILITY AND POPULATION ANALYSIS |
| Discussion Leader: Martyn Smith (UC Berkeley) |
7:30 pm - 8:20 pm | David Christiani (Harvard)
"Gene-Environment Interactions: the case of lung cancer" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Habibul Ahsan (University of Chicago)
"Molecular Epidemiology and Prevention of Arsenic-Induced Human Diseases" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | EPIGENETIC TOXICOLOGY / BIOMARKER DISCOVERY |
| Discussion Leader: Ed Lobenhofer (Cogenics) |
9:00 am - 9:50 am | Karl Kelsey (Harvard)
"Carcinogen Associated Epigenetic Silencing" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:20 am | Jay Goodman (Michigan State)
"Altered DNA Methylation: An Epigenetic Mechanism Underlying Carcinogenesis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:20 pm | Jeremy Burt (Michigan State)
"Genome-wide location analysis of TCDD-Mediated Promoter Binding of the Aryl Hydrocarbon Receptor" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PREDICTIVE TOXICOLOGY: APPLICATIONS AND PERSPECTIVE |
| Discussion Leader: Craig Thomas (Lilly) |
7:30 pm - 8:20 pm | Jiri Aubrecht (Pfizer)
"Application of Genomics to Evaluating Mechanisms of Genotoxicity and Carcinogenicity: Status and Future Directions" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Bob Roth (Michigan State)
"Toxicogenomics - Integration with Understanding Drug-Mediated Inflammation - Current and Future" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |