SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Issues in Basic Virology I |
| Discussion Leader: Inder Verma, Ph.D. (Salk Institute for Biological Studies) |
| Priscilla A. Schaffer, Ph.D. (Harvard, Beth Israel Deaconess Medical Center)
"Viral Gene Expression in Neuronal and Non-neuronal Cells: The Dual Life Cycle of Herpes Simplex Virus." |
| Matthew D. Weitzman, Ph.D. (Salk Institute for Biological Studies)
"Cellular recognition of viral genomes" |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Issues in Basic Virology II |
| Discussion Leader: Inder Verma, Ph.D. (Salk Institute for Biological Studies) |
| Beverly Davidson, Ph.D. (University of Iowa) "Silencing dominant neurodegenerative disease genes using RNAi" |
| John F. Englehardt, Ph.D. (University of Iowa, Medical Center)
"Intracellular barriers to recombinant AAV transduction in polarized airway epithelia." |
| Doug McCarty, Ph.D. (University of North Carolina)
"Identifying rate-limiting step for efficient AAV vector transduction." |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Vector Genome Biology I |
| Discussion Leader: TBA |
| Fredric D. Bushman, Ph.D. (Salk Institute)
"Retroviral DNA Integration" |
| David W. Russell, M.D., Ph.D. (University of Washington)
"Random and Targeted Integration of AAV Vectors" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Vector Genome Biology II |
| Discussion Leader: TBA |
| Joseph C. Glorioso III, Ph.D. (University of Pittsburgh, School of Medicine)
"HSV Vector Design: Escape From Transgene Silencing" |
| Dusty Miller, Ph.D. (Fred Hutchinson Cancer Research Center)
"Vectors for Pulmonary Gene Transfer" |
11:00 am | Group Photo |
| Mark A. Kay, M.D., Ph.D.
"Mechanisms of Vector Persistence in Vivo" |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Host Vector Interactions I |
| Discussion Leader: James M. Wilson, M.D., Ph.D. (University of Pennsylvania) |
| Hidde Ploegh, Ph.D. (Harvard Medical School)
"Viral immune evasion: an update" |
| Pedro Lowenstein, M.D. Ph.D. (Gene Therapeutics Research Institute)
"The neuroimmunology of gene therapy for brain diseases: basic aspects and their clinical consequences" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Host Vector Interactions II |
| Discussion Leader: James M. Wilson, M.D., Ph.D. (University of Pennsylvania) |
| Katherine High, M.D. (Children's Hospital of Philadelphia)
"Immune responses in AAV-mediated gene transfer" |
| Donald Kohn, Ph.D. (USC School of Medicine)
"Gene Expression from Lentiviral Vectors in Stem Cells" |
| Richard Katz, Ph.D. (The Fox Chase Cancer Center)
"The biology of retroviral nuclear entry, integration and silencing" |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Clinical Applications I |
| Discussion Leader: Savio Woo, Ph.D. (Inst. for Gene Therapy and Molecular Medicine) |
| Irvin S.Y. Chen, Ph.D. (UCLA Aids Institute)
"Gene therapy with and against HIV-1" |
| John Rossi, Ph.D. (City of Hope, Beckman Research Institute)
"Lentiviral vector delivery of therapeutic siRNAs and shRNAs to primary hematopoietic precursor cells for the treatment of HIV" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Clinical Applications II |
| Discussion Leader: Savio Woo, Ph.D. (Inst. for Gene Therapy and Molecular Medicine) |
| William S.M. Wold, Ph.D. (St. Louis University School of Medicine)
"Oncolytic Adenovirus Vectors that Overexpress ADP" |
| Andre Lieber, Ph.D. (University of Washington)
"Tropism-modified oncolytic adenoviruses" |
| John Forsayeth, Ph.D. (Avigen, Inc.)
"Neurological Applications of AAV" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Technologies I |
| Discussion Leader: TBA |
| Markus Grompe, M.D. (Oregon Health Sciences University)
"Non-viral gene transfer into stem cells" |
| Michele Calos, Ph.D. (Stanford University)
"Site Specific Integration for Gene Therapy" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |