SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments |
7:40 pm - 9:30 pm | OPENING SESSION |
| Discussion Leader: Haian Fu (Emory University, USA) |
7:40 pm - 8:25 pm | Keynote Address: John Scott (Vollum Institute, USA)
"The Molecular Architecture of Signaling Complexes" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Keynote Address: Tony Pawson (Samuel Lunenfeld Research Institute, Canada)
"TBA" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | STRUCTURE AND LIGAND RECOGNITION |
| Discussion Leader: David C. Klein (National Institutes for Health, USA) |
9:00 am - 9:25 am | Michael Yaffe (Center for Cancer Research, MIT, USA) "A Novel Role for 14-3-3 Sigma in Mitosis" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Louis Mahadevan (University of Oxford, UK) "Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Tomas Obsil (Charles University, Prague, Czech Republic) "14-3-3 protein C-terminal stretch: the role of its conformation in the regulation of ligand binding" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Declan Doyle (Oxford University, UK) "Structures of 14-3-3 isoforms" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Walter Kolch (Beatson Cancer Research, Glasgow, UK) "14-3-3 and Raf regulation, Raf heterodimerisation" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MITOGENIC AND ONCOGENIC SIGNAL TRANSDUCTION |
| Discussion Leader: Guri Tzivion (Karmanos Cancer Institute, Wayne State University, USA) |
7:30 pm - 7:55 pm | Heiko Hermeking (Max-Planck-Institute of Biochemistry, Germany) "Analysis of 14-3-3sigma, a p53-regulated isoform silenced in cancer" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Satoshi Inoue (University of Tokyo, Japan) "Post-translational modification of 14-3-3sigma by E3 ligase Efp" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Guri Tzivion (Karmanos Cancer Institute, Wayne State University, USA) "14-3-3 proteins as potential oncogenes" |
9:05 pm - 9:15 pm | Discussion |
TUESDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | GENETICS AND DEVELOPMENT |
| Discussion Leader: Tony Muslin (Washington University School of Medicine, USA) |
9:00 am - 9:25 am | Paul van Heusden (Leiden University, the Netherlands) "The yeast Saccharomyces cerevisiae as model organism to study 14-3-3 protein function" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Anthony Wynshaw-Boris (University of California, San Diego, USA) "The role of 14-3-3 proteins during brain development" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Maria Zannis-Hadjopoulos (McGill Cancer Centre, Montreal, Canada) "The cruciform binding activity of 14-3-3 as a regulator of DNA replication" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:50 am | Jan Szopa (University of Wroclaw, Poland) "Study of 14-3-3 Gene Promoters" |
11:50 am - 12:00 pm | Discussion |
12:45 pm | Group Photo Followed by Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 12:30 pm | CELL CYCLE CONTROL AND APOPTOSIS |
| Discussion Leader: Heiko Hermeking (Max-Planck-Institute of Biochemistry, Germany) |
7:30 pm - 7:55 pm | Haian Fu (Emory University, USA) "Development of 14-3-3 modulators" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Angel F. Lopez (IMVS, Hanson Centre, Adelaide, Australia) "Regulation of cytokine receptor signalling by 14-3-3 proteins" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:45 pm | Jo Woodcock (IMVS, Adelaide, Australia) "14-3-3 is a sphingolipid-binding protein" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Ulf Rapp (Institut fuer Medizinische Strahlenkunde und Zellforschung, Wuerzburg, Germany:) "14-3-3 and regulation of membrane interaction of BAD" |
9:15 pm - 9:25 pm | Discussion |
WEDNESDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | METABOLIC REGULATION |
| Discussion Leader: Carol MacKintosh (University of Dundee, Scotland, UK) |
9:00 am - 9:25 am | David C. Klein ( National Institutes for Health, USA) "The Biology of the 14-3-3/AANAT Complex" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Carol MacKintosh (University of Dundee, Scotland, UK) "14-3-3s regulate nutrient assimilation in plant and human cells in response to growth factors and energy stress" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 10:55 am | Aziz Ghahary (University of British Columbia, Canada) "Biological Role of Extracellular 14-3-3 Proteins in Normal and Pathological Conditions" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Patrizia Aducci (University of Rome-Tor Vergata, Italy) "Regulation of the Potassium Channel Kat1 by 14-3-3 Proteins" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Claudia Oecking (University of Tuebingen, Germany) "Co- structure of 14-3-3 in complex with a domain of the H+-ATPase" |
12:05 pm - 12:15 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | HOT TOPICS: NOVEL FUNCTIONS AND REGULATION |
| Discussion Leader: Michael Yaffe (Center for Cancer Research, MIT, USA) |
7:30 pm - 7:55 pm | Tony Muslin (Washington University School of Medicine, USA) "Differential role of 14-3-3 family members in Xenopus development" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Robert Rottapel (Ontario Cancer Institute, Canada) "14-3-3 regulates the mitotic spindle RhoGEF LFC" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Nick La Thangue (Oxford, UK) "14-3-3 proteins integrate E2F activity with the DNA damage response" |
9:05 pm - 9:15 pm | Discussion |
THURSDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 9:30 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:30 am - 12:30 pm | 14-3-3 AND BRAIN DISEASES |
| Discussion Leader: Markus Otto (University of Ulm, Germany) |
9:30 am - 9:55 am | Markus Otto (University of Ulm, Germany) "14-3-3 proteins in the diagnosis of neurodegenerative disease" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:30 am | Azad Bonni (Harvard Medical School, USA)
(Dorothy Dillon Eweson Lecturer on the Advances in Aging Research)
"MST Regulation of Oxidative Stress Responses and Longevity" |
10:30 am - 10:40 am | Discussion |
10:40 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Efthimios Skoulakis (Institute of Molecular Biology and Genetics, Vari, Greece) "14-3-3s enhance tauopathies in Drosophila" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Michael C Berndt (Immunology, AMREP, Melbourne, Australia) "14-3-3 zeta binding to platelet GPIb-IX-V adhesion receptor, role in heart disease and stroke" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Mary Waye (The Chinese University of Hong Kong) "Genetic susceptibility of Suicide: 14-3-3 epsilon or SSAT?" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session IV |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | 14-3-3 IN RECEPTOR SIGNALING |
| Discussion Leader: Claudia Oecking (University of Tuebingen, Germany) |
7:30 pm - 7:55 pm | Bengt Hallberg (Umea University, Sweden) "Exoenzyme S residues that mediate the interaction with 14-3-3 and its biological activity" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Min Li (Johns Hopkins University, USA) "Inducible membrane trafficking by mode III 14-3-3 binding" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Bert de Boer (Vrije Universiteit, Amsterdam, the Netherlands) "Isoform specific functions of 14-3-3 proteins in enzyme regulation and hormonal signaling" |
9:05 pm - 9:15 pm | Discussion |
FRIDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am | Depart |