| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | BINDING CONSEQUENCES |
| Discussion Leader: Neal Fedarko (Johns Hopkins University) |
| 7:40 pm - 8:15 pm | Joanne E. Murphy-Ullrich (University of Alabama at Birmingham)
"Extracellular matrix control of cell behaviour" |
| 8:15 pm - 8:25 pm | Discussion |
| 8:25 pm - 9:00 pm | Elizabeth A. Komives (University of California, San Diego)
"Folding and binding in NF-kappaB regulation" |
| 9:00 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | Platform Presentation: (10 minute talk, 5 minutes for questions)
Cezary Marcinkiewicz (Temple University)
"KTS disintegrin, exogenous ligands for a1b1 integrin, are potent inhibitors of angiogenesis" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | THE SIBLING AND CCN FAMILIES - THE INSIDE STORY AND OTHER TALES |
| Discussion Leader: Jaro Sodek (University of Toronto) |
| 9:00 am - 9:25 am | Jaro Sodek (University of Toronto)
"Intracellular Functions of SIBLING Proteins" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Mari Shinohara (Harvard Medical School)
"Intracellular OPN in antigen-presenting cells" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Maurice Ringuette (University of Toronto)
"Intracellular functions of SPARC/ON" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Bernard Perbal (Université Paris, France)
"CCN nuclear localization" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:30 pm | Platform Presentations
Three 10 minute talks (5 minutes for questions) selected from abstracts |
| 1. Pi-Ling Chang (University of Alabama)
"Induced Osteopontin: a potential rate limiting factor in tumor promotion" |
| 2. Harvey Goldberg (Univ West. Ontario)
"Bone sialoprotein stimulates focal adhesion-related signlaing pathways involved in migration and survival of breast and prostate cancer cells" |
| 3. Susie Nilsson (Australian Stem Cell Centre)
"Regulation of haemopoietic stem cells by OPN is mediated by specific interactions with a4b1 and a9b1 integrins"
|
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GENOMIC AND CIS-REGULATORY ANALYSIS OF SIBLING & CCN GENES |
| Discussion Leader: Masaki Noda (Tokyo Medical and Dental University, Japan) |
| 7:30 pm - 8:05 pm | Masaki Noda (Tokyo Medical and Dental University, Japan)
"Osteopontin and bone cell regulation" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Ernie Canalis (Saint Francis Hospital and Medical Center)
"Expression and regulation of CCN genes in bone" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50pm - 9:15 pm | Margarete Goppelt-Struebe (Universitat Erlangen-Nurnberg, Germany)
"Mechanical signaling and CTGF/CCN2 gene transcription" |
| 9:15 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SIBLINGS, DIFFERENTIATION, AND CANCER |
| Discussion Leader: Vincent Castronovo (University of Li∂ge, Belgium) |
| 9:00 am - 9:25 am | Akeila Bellahcene (University of Li∂ge, Belgium)
"SIBLINGs as markers of bone metastases" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Alison Allan (University of Western Ontario)
"Relationship between OPN, integrins, and thrombin during breast cancer metastasis" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Coffee Break |
|
10:30 am - 10:55 am | Susan Rittling (Forsyth Institute)
"Interactions of OPN and CSF-1 in bone metastasis" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Kalu U.E. Ogbureke (Medical College of Georgia)
"Alteration of SIBLING expression in oral premalignant lesion" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:30 pm | Platform Presentations
Three 10 minute talks (5 minutes for questions) selected from abstracts |
| 1. Virginie Lamour (Universite de Liege)
"Runx2 and HDAC3 mediated repression is relieved in differentiating human osteoblasts like cells to allow high BSP expression" |
| 2. Lalita Shevde-Samant (University of So. Alabama)
"Role of osteopontin in breast cancer tumorigenicity and metastasis" |
| 3. Atrayee Banerjee (Texas A&M)
"Osteopontin-mediated multi-integrin signaling: A mechanism for higher hepatic neutrophil infiltration and liver injury in female alcoholic liver disease" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BIOACTIVE FRAGMENTS |
| Discussion Leader: Cecilia Giachelli (University of Washington) |
| 7:30 pm - 8:05 pm | Lucy Liaw (Maine Medical Research Institute)
"MMP cleavage of osteopontin to generate bioactive fragments" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Dennis Clegg (University of California at Santa Barbara)
"Osteopontin fragments in the eye" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm - | Vijaya Rao (The University of Texas Health Center at Tyler, TX)
"CCN processing in Cancer" |
| 9:15 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CCNS, DIFFERENTIATION, AND CANCER |
| Discussion Leader: David Brigstock (Ohio State University) |
| 9:00 am - 9:25 am | Ruth Lupu (Northwestern University)
"CCN1 and Breast Cancer Progression" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Masaharu Takigawa (Okayama University, Japan)
"CTGF/CCN2 in bone metastasis and tumor angiogenesis" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Murray Korc (Dartmouth)
"CTGF and pancreatic stroma" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Sushanta Banerjee (V.A. Medical Center, Kansas City, Missouri)
"WISP2?CCN5 in breast cancer" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:30 pm | Platform Presentations
Three 10 minute talks (5 minutes for questions) selected from abstracts |
| 1. Mary Lou Cutler (USUHS)
"Glucocorticoid induced expression of Connective Tissue Growth Factor in Tumor Promotion" |
| 2. Carmel Lawrencia (Columbus Children’s Hospital)
"CTGF siRNA delivered to fibrosing liver with a cyclic RGD peptide is anti-fibrotic" |
| 3. Sabrina Sangaletti (Instituto Nazionale Tumori)
"Macrophage-derived SPARC regulates tumor microenvironment towards metastasis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | SIBLINGS/CCNS AND NORMAL PHYSIOLOGY |
| Discussion Leader: Jerry Feng (University of Missouri-Kansas City) |
| 7:30 pm - 8:05 pm | Susan Schiavi (Applied Genomics, Genzyme Corp)
"SIBLINGs as phosphotonins" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Jerry Feng (University of Missouri-Kansas City)
"Rescue of the DMP-1 null mouse" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Steve Harris (U. of Texas Health Science Center at San Antonio)
"Identification of enhancer units In the DMP1 and MEPE gene that control osteocyte specificity and response to mechanical signaling" |
| 9:15 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | INFLAMMATION AND OTHER HOT TOPICS |
| Discussion Leader: David Denhardt (Rutgers University) |
| 9:00 am - 9:25 am | Dennis Bruemmer (University of Kentucky)
"OPN, inflammation and obesity" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Lester Lau (University Illinois)
"CCN1 and inflammation" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Marta Scatena (Univ of Washington)
"OPN and macrophage function" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Esben S. Sørensen (Aarhus University)
"OPN: Structure-Function Relationships" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:30 pm | Platform Presentations
Three 10 minute talks (5 minutes for questions) selected from abstracts |
| 1. Eun Mi Hur (California Insitute of Technology)
"Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells" |
| 2. Kathryn Wang (Rutgers)
"Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy through modulating corticosteroid production" |
| 3. Johannes Weiss (University of Ulm)
"OPN is a central factor in stabilizing chronification of T-cell mediated disease such as chronic allergic contact dermatitis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEYNOTE SPEAKER |
| Discussion Leader: Cecilia Giachelli (University of Washington) |
| 7:30 pm - 9:00 pm | Keynote Speaker: Larry Steinman (Stanford University)
"Osteopontin and T cell function" |
| 9:00 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
