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Atherosclerosis
Gordon Research Conference

Systems-Interaction in Atherosclerosis

Dates

June 18-23, 2017

Location

Grand Summit Hotel at Sunday River
Newry, ME Site Information

Organizers

Chairs:
Matthias Nahrendorf & Stefanie Dimmeler

Vice Chairs:
Catherine Hedrick & Carlos Fernandez-Hernando

Application Deadline

Applications for this meeting must be submitted by May 21, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

Several decades of successful reductionist research led to substantial inroads in understanding the pathophysiology of atherosclerosis. This work established for instance time-tested and new treatment options such as statins and PCSK9 inhibitors. At the 2017 Gordon Atherosclerosis conference, we propose to discuss how connection of traditionally isolated research fields related to atherosclerosis may instill capabilities to design conceptually new treatment strategies. Recent advances, for instance uncovering interactions of metabolism and microbiota with systemic inflammation, highlight that building the "atherosclerosis connectome" has already begun. We propose to discuss, among others, the following questions: How do microRNA, other novel non-coding RNAs and altered gene expression patterns influence cellular action, metabolism and immunity? Can we retrain immunity towards inflammation resolution? How are the hematopoietic and central nervous system affected in atherosclerosis? Where do stromal and immune cells originate, and how do they interact in disease progression? Can imaging provide dynamic "biopsies" in out-of-reach tissues? How do myocardial and vascular health interact? We will strive to make this conference a catalyst for entering new research fields, providing the traditionally communicative environment that has fostered atherosclerosis research since the first Gordon Atherosclerosis conference happened in 1973. No matter whether you were born before or after that date, please consider joining us in beautiful Sunday River!

Related Meeting

This GRC will be held in conjunction with the "Atherosclerosis" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmReading and Reaching Plaque Biology
Discussion Leader: Elena Galkina (Eastern Virginia Medical School, USA)
7:40 pm - 8:15 pmThorsten Mempel (Massachusetts General Hospital, USA)
"Watching Cells Communicate: State of the Art in Intravital Microscopy"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmWillem Mulder (Icahn School of Medicine at Mount Sinai, USA)
"Drug Delivery to Plaques"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmZahi Fayad (Mount Sinai Hospital, USA)
"Brain Inflammation Imaging in Patients"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHematopoiesis Modified by Cardiovascular Risk and Co-Morbidity
Discussion Leader: Nadia Rosenthal (The Jackson Laboratory, USA)
9:00 am - 9:35 amPaul Frenette (Albert Einstein College of Medicine / Montefiore Medical Center, USA)
"(Risk) Factors Regulating the Bone Marrow Stem Cell Niche"
9:35 am - 9:50 amDiscussion
9:50 am - 10:10 amPartha Dutta (University of Pittsburgh Medical Center, USA)
"Targeting Splenic Hematopoietic Stem Cells in Cardiovascular Disease"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:00 amAlan Tall (Columbia University, USA)
"Abnormal Hematopoiesis, Lipids and Athero-Thrombosis"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amFilip Swirski (Massachusetts General Hospital / Harvard Medical School, USA)
"Hematopoietic Tissue's Long Distance Relationships"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmKenneth Walsh (Boston University School of Medicine, USA)
"Somatic Mutations in Hematopoietic Cells that Contribute to Vascular Disease"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdaptive Immunity - Friend or Foe?
Discussion Leader: Katey Rayner (University of Ottawa Heart Institute, Canada)
7:30 pm - 7:50 pmKlaus Ley (La Jolla Institute of Allergy and Immunology, USA)
"Failure of Protective Autoimmunity in Atherosclerosis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmElena Galkina (Eastern Virginia Medical School, USA)
"Regulatory T-Cells in Atherosclerosis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAndrew Lichtman (Brigham and Women's Hospital, USA)
"Lymphoid Cells in Atherosclerosis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmZiad Mallat (University of Cambridge, United Kingdom)
"Intersection of Innate and Adaptive Immune Responses"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInnate Immunity and Plaque Cell Origins
Discussion Leader: Gwendalyn Randolph (Washington University in St. Louis, USA)
9:00 am - 9:20 amElaine Raines (University of Washington, USA)
"Proteolytic Switch Controlling Lesion Macrophage Proliferation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amChristian Weber (Ludwig Maximilian University of Munich, Germany)
"Targeting Chemokines to Control Plaque Cell Infiltration"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amClinton Robbins (University of Toronto / University Health Network, Canada)
"Resident Macrophages in the Vasculature: 'I Am Already Here'"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amGary Owens (University of Virginia, USA)
"IL1β Promotes Fibrous Cap SMC Stabilization of Late Stage Lesions"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJason Kovacic (Icahn School of Medicine at Mount Sinai, USA)
"Endothelial to Mesenchymal Transition Contributes to Plaque Formation and Correlates with Instability"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmKarishma Rahman (New York University School of Medicine, USA)
"Recruitment of Monocytes and Their Conversion to Macrophages Are Required for Regression of Atherosclerosis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMyocardial Ischemia, Healing and Regeneration
Discussion Leader: Catherine Hedrick (La Jolla Institute for Allergy and Immunology, USA)
7:30 pm - 7:50 pmKory Lavine (Washington University in St. Louis, USA)
"Resident Macrophages Are Not All Equal"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmNadia Rosenthal (The Jackson Laboratory, USA)
"Macrophages in Regeneration"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSlava Epelman (University Health Network, Canada)
"Macrophages in Myocardial Repair"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMaarten Hulsmans (Massachusetts General Hospital, USA)
"Novel Functions of Cardiac Resident Macrophages"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCoding and Non-Coding Genetics
Discussion Leader: Michelle Olive (National Heart, Lung, and Blood Institute, NIH, USA)
9:00 am - 9:20 amJake Lusis (University of California, Los Angeles, USA)
"Genetic Diversity and Atherosclerosis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amKathryn Moore (New York University Medical Center, USA)
"Non-Coding RNAs and Lipid Metabolism"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amLesca Holdt (Ludwig Maximilians University of Munich, Germany)
"Circular RNAs in Atherosclerosis"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amMark Feinberg (Brigham and Women's Hospital, USA)
"Reprogramming Endothelial Inflammation by Targeting a lncRNA"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amAndreas Wilhelm Heumüller (Institute of Cardiovascular Regeneration, Germany)
"The Circular RNA cZNF292 Localizes to the ER/Caveolae-Fraction and Controls eNOS Phosphorylation in Endothelial Cells"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amTamer Sallam (University of California, Los Angeles, USA)
"Epigenetic Regulation of Cholesterol Efflux and Atherosclerosis by MeXis, a Novel Non-Coding RNA"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmFlorian Leuschner (Heidelberg University Hospital, Germany)
"The Cardiac Microenvironment Uses Non-Canonical WNT Signaling to Activate Monocytes After MI"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmClaudia Calcagno (Icahn School of Medicine at Mount Sinai, USA)
"Endothelial Permeability MRI the Aortic Root of Atherosclerotic Mice"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmClinical Input and Output
Discussion Leader: Kathryn Moore (New York University Medical Center, USA)
7:30 pm - 7:50 pmHeribert Schunkert (Deutsches Herzzentrum Muenchen, Germany)
"GWAS to Identify Relevant Human Targets"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAndreas Zeiher (Goethe University Frankfurt, Germany)
"Novel Lipid Lowering Strategies - PCSK9"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPeter Libby (Brigham and Women's Hospital, USA)
"Targeting Inflammation in Atherosclerosis - Cytokines, Colchicine, and Beyond"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDong-Eog Kim (Molecular Imaging and Neurovascular Research Laboratory, Dongguk University, South Korea)
"Advanced Imaging for Stroke Management"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMicrobiotic, Metabolic and Lipid Modifiers of Atherosclerosis
Discussion Leader: Elaine Raines (University of Washington, USA)
9:00 am - 9:20 amChristoph Binder (Medical University of Vienna, Austria)
"Oxidation-Specific Epitopes Define the Content and Activity of Extracellular Vesicles"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amStanley Hazen (Cleveland Clinic, USA)
"Microbiome and Cardiometabolic Disease"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amYajaira Suarez (Yale University School of Medicine, USA)
"Lanosterol Modulates TLR4 Mediated Innate Immune Responses in Macrophages"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amWilliam Sessa (Yale University, USA)
"Novel Mechanisms of Lipid Metabolism by Endothelium"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amChiara Giannarelli (Icahn School of Medicine at Mount Sinai, USA)
"High-Dimensional Single-Cell Analysis of Tissue Heterogeneity in Human Atherosclerosis"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amMaria Grandoch (Institute for Pharmacology and Clinical Pharmacology, University Hospital Duesseldorf, Germany)
"Dapagliflozin Reduces Thrombin-Mediated Platelet Activation in Atherosclerosis"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmInnate Immune Memory and Epigenetics
Discussion Leader: Lesca Holdt (Ludwig Maximilians University of Munich, Germany)
5:30 pm - 5:50 pmGwendalyn Randolph (Washington University in St. Louis, USA)
"Immunity's Regulation of HDL Trafficking"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmEike Latz (University of Bonn, Germany)
"Epigenetic Signals in Atherosclerosis"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmKonstantinos Stellos (Goethe University Frankfurt, Germany)
"RNA Modifications in Vascular Inflammation"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmNiels Riksen (Radboud University Nijmegen Medical Centre, The Netherlands)
"Metabolic and Epigenetic Reprogramming During Induction of Trained Immunity"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL137211-01 from the National Heart, Lung and Blood Institute.The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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