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Barrier Function of Mammalian Skin
Gordon Research Conference

Convergence of Biological and Technological Frontiers of Skin Barrier

Dates

August 13-18, 2017

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chairs:
Samir S. Mitragotri & Joachim W. Fluhr

Vice Chairs:
Marek Haftek & David J. Moore

Meeting Description

The 15th meeting of the Gordon Research Conference on "Barrier Function of Mammalian Skin" will be held at the Waterville Valley Resort between August 13th and August 18th, 2017. This Gordon Conference is focused on the scientific topics broadly related to skin barrier properties.

Mammalian skin, the largest organ of the body, forms the principal protection against exogenous threats. At the same time, it offers an active interface to communicate with the external world through exchange of materials and signals. Skin also offers a platform to harvest diagnostic signals from and deliver therapeutics into the body. Thus, skin has received significant attention in the scientific community for fundamental as well as translational research. A large community of researchers representing biologists, clinicians, physical and chemical scientists, engineers, pharmaceutical and cosmetic scientists are actively engaged in skin barrier research. This Gordon Research Conference serves as a platform to bring together this diverse community around this scientifically stimulating topic. The general theme of this conference is "Technology meets Biology", and the focus is on convergence of technology and biology to meet unmet needs in dermatological/transdermal research and patient/consumer interests. Speakers will represent technology and biology within the same session with the goal of providing an interface between the two and promote an active dialog.

Six general scientific themes will be highlighted in the conference: UV and the Barrier, Atopic dermatitis and Ichthyosis, Skin hydration, Wound healing, Follicular disorders, Itch and sensitive skin, and Tools and Technologies. These areas represent some of the most urgent and unmet clinical needs in the field. Significant advances have been made over the years to understand the underlying biology that defines the pathophysiology of clinical conditions related to barrier defects in terms of their origin as well clinical implications. At the same time, technologies that make use of tools such as wearable devices, high throughput screening, therapeutic devices, spectroscopy and mathematical models have also developed to understand, detect or intervene barrier related problems. This conference aims to explore the convergence of these approaches and bring together communities of biologists and technologies to pave the way for future discoveries and innovation.

Related Meeting

This GRC was held in conjunction with the "Barrier Function of Mammalian Skin" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Convergence of Biology and Technology
Discussion Leaders: Samir Mitragotri (Harvard University, USA) and Joachim Fluhr (Charite - Universitaetsmedizin Berlin, Germany)
7:40 pm - 8:20 pmMark Prausnitz (Georgia Institute of Technology, USA)
"Development of Microtechnologies for Medical Applications in the Skin"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmMarjana Tomic-Canic (Miller School of Medicine, University of Miami, USA)
"Innovations in Wound Healing: Mechanisms, Diagnostics and New Treatments"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAtopic Dermatitis and Ichthyosis
Discussion Leaders: Dennis Roop (University of Colorado Anschutz Medical Campus, USA) and Eva Benfeldt (University of Copenhagen, Denmark)
9:00 am - 9:30 amTheodora Mauro (University of California, San Francisco, USA)
"Atopic March: Role of the Epidermal Barrier Function"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amYasmine Belkaid (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Microbiota Control of Infections"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amGroup Photo / Coffee Break
11:00 am - 11:30 amPieter Dorrestein (University of California, San Diego, USA)
"Chemistry Associated with Skin Microbial Communities - Detection, Manipulation and Taking Control"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmThomas White (Stony Brook University, USA)
"Connexin Inhibition Alleviates Skin Disease in a Mouse Model of KID Syndrome"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Eva Benfeldt (University of Copenhagen, Denmark)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmUV and the Barrier
Discussion Leaders: Walter Holleran (University of California, San Francisco, USA) and Neil Kitson (University of British Columbia, Canada)
7:30 pm - 8:00 pmMartine Meinke (Charite - Universitaetsmedizin Berlin, Germany)
"Free Radical Formation and Radical Scavenging Activity of the Epidermal Barrier"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMark Saltzman (Yale University, USA)
"Bioadhesive Nanoparticles for Topical Delivery to Skin"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmKenneth Tsai (Moffitt Cancer Center, USA)
"UV-Induced Somatic Mosaicism as a Marker of Skin Cancer Risk"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWound Healing
Discussion Leader: Marjana Tomic-Canic (Miller School of Medicine, University of Miami, USA)
9:00 am - 9:30 amMaria Morasso (National Institutes of Health, USA)
"The Molecular Anatomy of Oral and Cutaneous Wound Healing"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amKaushal Rege (Arizona State University, USA)
"Laser Activated Sealants for Skin Closure"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amKyeong Mi Kim (OliX Pharma, South Korea)
"siRNA Therapeutics Against Skin Diseases"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmWestbrook Weaver (Tempo Therapeutics, Inc, USA)
"Improving Integration of Biomaterials During Dermal Regeneration"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSkin Hydration
Discussion Leaders: Richard Guy (University of Bath, United Kingdom) and Michael Roberts (University of Queensland / University of South Australia, Australia)
7:30 pm - 8:00 pmAnthony Rawlings (AVR Consulting Ltd, United Kingdom)
"Dry Skin and the Molecular Basis of Stratum Corneum Maturation and Hydration"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmGerald Kasting (University of Cincinnati, USA)
"The Skin Barrier and an Emerging Technological Route of Analyte Access Through Eccrine Sweat"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmLuis Monteiro Rodrigues (Universidade Lusofona, Portugal)
"Can Microcirculation Influence the Epidermal Barrier? (Using Mathematical Modeling to Simplify Complex Physiological Relationships In Vivo)"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmItch and Sensitive Skin
Discussion Leaders: Peter Elias (Veterans Administration Medical Center / University of California, San Francisco, USA) and Kenneth Feingold (Veterans Administration Medical Center / University of California, San Francisco, USA)
9:00 am - 9:30 amGil Yosipovitch (University of Miami, USA)
"Why Is My Dry Skin Itchy? Examining the Causes of Itch Associated with Skin Barrier Function and Structure"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amLaurant Misery (University of Western Brittany, France)
"Sensitive Skin and Skin Barrier"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amPraveen Vemula (Institute for Stem Cell Biology and Regenerative Medicine, India)
"Rapid Translation of Innovative Skincare Technologies - The Skintifique Story"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmSanja Kezic (Academic Medical Centre, The Netherlands)
"Corneocyte Surface Topography in Skin Inflammatory Diseases"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmSelected Poster Presentations
Discussion Leaders: David Moore (GlaxoSmithKline, USA) and Marek Haftek (CNRS / University of Lyon, France)
7:30 pm - 7:40 pmShort Talk Selected from Poster Abstracts
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmShort Talk Selected from Poster Abstracts
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmShort Talk Selected from Poster Abstracts
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmShort Talk Selected from Poster Abstracts
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmShort Talk Selected from Poster Abstracts
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmShort Talk Selected from Poster Abstracts
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk Selected from Poster Abstracts
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTools and Technologies
Discussion Leaders: Nicole Brogden (University of Iowa, USA) and Reinhard H. Neubert (Martin Luther University of Halle-Wittenberg, Germany)
9:00 am - 9:30 amJohn Newsam (Tioga Research Inc., USA)
"Using Higher Throughput Screening in Topical Formulation Innovation"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amDennis Roop (University of Colorado Anschutz Medical Campus, USA)
"Using Mouse Models to Understand How Epidermal Barrier Defects Lead to Predisposition to Develop Atopic Dermatitis"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amPankaj Karande (Rensselaer Polytechnic Institute, USA)
"3D Printing of a Full-Thickness, Autologous and Vascularized Human Skin"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmClaus-Michael Lehr (Helmholtz Centre for Infection Research, Germany)
"Follicular Penetration of Nanoparticles as Platform for Non-Invasive Antigen Delivery to the Skin"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmFollicular Disorders
Discussion Leaders: Gerald Kasting (University of Cincinnati, USA) and Gopinathan Menon (California Academy of Sciences, USA)
5:30 pm - 6:00 pmJoke Bouwstra (Leiden Academic Centre for Drug Research (LACDR), Leiden University, The Netherlands)
"Hollow and Coated Microneedles for Dermal Vaccination"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 6:40 pmDilip Paithankar (Sebacia, Inc., USA)
"Targeting Follicular Diseases with Plasmonic Resonant Particles and Optical Pulses"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:20 pmJuergen Lademann (Charite - Universitaetsmedizin Berlin, Germany)
"New Perspectives in Drug Delivery: Triggered Release of Drugs on Nanoparticles in Hair Follicles"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by (1 R13AR72527-01) from the National Institute Of Arthritis And Musculoskeletal And Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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