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Bioenergetics
Gordon Research Conference

From Molecular Structures and Mechanisms to Cellular Bioenergetics in Health and Disease

Dates

June 4-9, 2017

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Judy Hirst

Vice Chair:
Wayne D. Frasch

Meeting Description

The 2017 Gordon Research Conference on Bioenergetics will bring together scientists interested in the molecular and cellular aspects of biological energy conversion. The structures and mechanisms that biology uses to control, handle and conserve energy are fundamental to life, and central to many aspects of human health and disease. The meeting will promote an integrated, multidisciplinary view of energy metabolism, by encouraging discussions and exchange of information between researchers from a broad range of bioenergetics-related scientific disciplines. It will focus broadly on the following three areas. First, on new developments in the structure, mechanism, organisation and regulation of the large and complicated proton-pumping enzyme complexes of biological energy conservation: the respiratory electron transporting complexes, and the rotary ATP synthase machines. Second, on the roles and functions of the bioenergetic complexes in the cell – not only the production of ATP, but a significant contribution to oxidative stress, and the essential support of many diverse cellular metabolic pathways. Third, how bioenergetics enzymes can be exploited as drug targets in human diseases, including in cancer, mitochondrial and neurodegenerative diseases, with an additional emphasis on targeting the bioenergetics enzymes particular to pathogens. Finally, clear priorities for the meeting are to provide a platform for researchers on every level to present their most recent findings (whether in a formal scientific session or as a poster presentation) and to engage in active, stimulating and unfettered discussions. Particular emphasis will be placed on engaging postdoctoral researchers and graduate students in the meeting, and on promoting an atmosphere that is both welcoming and inspiring for younger researchers, as well as for established ones.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmThe Complexity of Mammalian Complex I
Discussion Leader: Judy Hirst (University of Cambridge, United Kingdom)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmJiapeng Zhu (Nanjing University of Chinese Medicine, China)
"Insights into the Structure and Mechanism of Mammalian Complex I"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmMike Ryan (Monash University, Australia)
"Assembly of Human Mitochondrial Complex I"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmUlrich Brandt (Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, The Netherlands)
"Assembly and Mechanism of Mitochondrial Complex I"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Respiratory Chain and Oxidative Stress
Discussion Leader: Susanne Arnold (Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, The Netherlands)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amArtur Osyczka (Jagiellonian University, Poland)
"Intermediate Radical States of Cytochromes bc1/b6f and Their Relation to ROS Production"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amAlberto Sanz Montero (Newcastle University, United Kingdom)
"Site Specific ROS Production in Health and Disease"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amIsha Jain (Massachusetts General Hospital, USA)
"Developing Hypoxia as a Therapy for Mitochondrial Disease"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amLothar Kussmaul (Boehringer Ingelheim Pharma GmbH & Co. KG, Germany)
"Lowering Oxidative Stress by Targeting the Flavin Site of Complex I: A Drug Discovery Approach"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStructures and Functions of Supercomplex Assemblies
Discussion Leader: Carola Hunte (Institute for Biochemistry and Molecular Biology, BIOSS, University of Freiburg, Germany)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmKaren Davies (Lawrence Berkeley National Laboratory, USA)
"Diversity of Mitochondrial Bioenergetic Complexes"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmCristina Ugalde (Instituto de Investigacion Hospital 12 de Octubre (i+12), Spain)
"Structural Interdependences Among Respiratory Chain Complexes and Respirasome Formation"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmPeter Brzezinski (Stockholm University, Sweden)
"Functional Interactions Within the Respiratory Chain"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAttacking the Bioenergetic Enzymes in Pathogens
Discussion Leader: Anthony Moore (University of Sussex, United Kingdom)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amKiyoshi Kita (Nagasaki University, Japan)
"Parasite Mitochondrial Respiratory Chains as a Drug Target: Complex II, III and the Alternative Oxidase"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amDirk Bald (VU University Amsterdam, The Netherlands)
"Targeting Oxidative Phosphorylation with Next-Generation Antibiotics"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amAkhil Vaidya (Drexel University College of Medicine, USA)
"Mitochondrial Targets in Parasites for Malaria Treatment"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amGregory Cook (University of Otago, New Zealand)
"Advancing Bacterial Type-II NADH:Quinone Oxidoreductases as a New Target Space for Drug Development"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBioenergetics on the Single Molecule Level
Discussion Leader: Robert Gennis (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmLars Jeuken (University of Leeds, United Kingdom)
"Single-Enzyme Studies of the Heme-Copper Oxidase, Cytochrome bo3, from Escherichia coli"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmKarin Busch (University of Muenster, Germany)
"Enhanced Respiration Is Correlated with Increased Mobility of Single F1FO ATP Synthase Complexes in the Inner Mitochondrial Membrane"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmHiroyuki Noji (The University of Tokyo, Japan)
"Single-Molecule Analysis of Bovine Mitochondrial ATPase"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDetermining the Structures and Mechanisms of Complex Proton-Pumping Redox Enzymes
Discussion Leader: Thorsten Friedrich (University of Freiburg, Germany)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:40 amPeter Rich (University College London, United Kingdom)
"Insights into Cytochrome c Oxidase Mechanism from Studies of Yeast Mitochondrial CcO"
9:40 am - 9:50 amDiscussion
9:50 am - 10:15 amLeonid Sazanov (Institute of Science and Technology Austria, Austria)
"Structure and Mechanism of Complex I: From Bacterial to Mammalian Systems"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amVille Kaila (Technical University of Munich (TUM), Germany)
"Understanding the Mechanism of Long-Range Proton-Coupled Electron Transfer in Respiratory Complex I"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amMaxie Roessler (Queen Mary University of London, United Kingdom)
"EPR Spectroscopic Investigations of Cluster N2 and Its Role in the Energy Coupling Mechanism of Complex I"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmMasatoshi Murai (Kyoto University, Japan)
"Characterization of the Ubiquinone Binding Pocket of Respiratory Complex I Through Specific Chemical Modifications"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Itay Budin (University of California, Berkeley, USA)
"Physical Regulation of Bacterial Respiration by Membrane Lipid Composition"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmLate-Breaking Topics / Young Investigator Presentations
Discussion Leader: Wayne Frasch (Arizona State University, USA)
7:30 pm - 7:45 pmSelected from Poster Abstracts: Valentina Giorgio (University of Padova, Italy)
"Calcium Binding to F-ATP Synthase Beta Subunit Triggers the Mitochondrial Permeability Transition"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmSelected from Poster Abstracts: Ivan Lopez-Montero (Complutense University of Madrid, Spain)
"Mechanical Interaction of F1F0-ATPase with Lipid Membranes"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmSelected from Poster Abstracts: Ubaldo Martinez-Outschoorn (Thomas Jefferson University, USA)
"Multi-Compartment Metabolism in Human Carcinomas"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmSelected from Poster Abstracts: Edward Owusu-Ansah (Columbia University Medical Center, USA)
"Regulation of Mitochondrial Complex I Biogenesis in Drosophila Skeletal Muscles"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmSelected from Poster Abstracts: Alastair Stewart (The Victor Chang Cardiac Research Institute, Australia)
"Cryo-EM Studies of E. coli ATP Synthase"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Denis Titov (Massachusetts General Hospital, USA)
"A Genetically Encoded Tool for Manipulation of the NAD+/NADH Ratio in Living Cells"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmF- and V-Type ATPases: Molecular Machines and Drug Targets
Discussion Leader: Karlett Parra (University of New Mexico, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:40 amJohn Walker (MRC Mitochondrial Biology Unit, Medical Research Council, United Kingdom)
"Structure, Mechanism and Regulation of ATP Synthases"
9:40 am - 9:50 amDiscussion
9:50 am - 10:15 amThomas Meier (Imperial College London, United Kingdom)
"Structure of Rotary ATP Synthase and Its Role as New Drug Target Against Tuberculosis"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amMichael Forgac (Tufts University School of Medicine, USA)
"Function of the V-ATPases in Nutrient Sensing and Cancer"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amAlena Zikova (Biology Centre, Czech Academy of Sciences, Czech Republic)
"Role of FoF1 ATP Synthase and IF1 in Bioenergetic Adaptions Occurring Throughout the Life Cycle of the Human Parasite Trypanosoma"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmJose Faraldo-Gomez (National Institutes of Health, USA)
"Mitochondrial ATP Synthase: The Good, the Bad and the Ugly"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Abhishek Singharoy (University of Illinois at Urbana-Champaign, USA)
"How Hexameric Protein-Protein Interfaces Harness Energy Within Molecular Motors: Chemomechanical Coupling in V-Type ATPases"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Electron Transport Chain as an Essential Component of Cellular Metabolic Networks
Discussion Leader: David Nicholls (Buck Institute for Research on Aging, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmKivanc Birsoy (The Rockefeller University, USA)
"Systematic Approaches to Study Mitochondrial Dysfunction in Mammalian Cells"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmChristian Frezza (MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, United Kingdom)
"Metabolic Alterations in Fumarate Hydratase Deficient Cells"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmJared Rutter (University of Utah, USA)
"Mitochondria, Metabolism and the Control of Cell Behavior"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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