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Musculoskeletal Biology and Bioengineering
Gordon Research Conference

Stepping Across Disciplines to Spur Innovation in Musculoskeletal Biology and Bioengineering

Dates

August 7-12, 2016

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Robert L. Mauck

Vice Chair:
Peter Johnson

Meeting Description

The field of musculoskeletal (MSK) biology and bioengineering is by its very nature interdisciplinary, typified by the unique collaborations amongst biologists, engineers, and clinician scientists. While this integrative approach has been quite fruitful in the advancement of MSK science, too often our focus tends to be "tissue-specific", with quite a lot of excellent work occurring in non-interacting tissue silos. This occurs despite the fact that the most significant advances in our field occur when we not only embrace different fields of study, but also adopt emerging concepts and tools from these disparate fields into our own work, by bridging disciplines, tissue types, and developmental systems.

With this in mind, the theme of the 2016 GRC is "Stepping Across Disciplines to Spur Innovation in Musculoskeletal Biology and Bioengineering". The aim of this program is to bring together thought leaders from across our field to discuss how their interdisciplinary approach has led to advances in MSK biology and bioengineering research. To emphasize the need to break through these "tissue silos", we have developed a program that addresses common themes that are agnostic of tissue type, highlighting advances and integrating new insights across tissue types. The goal of this meeting is to foster such interdisciplinary integration to drive innovation in MSK Biology and Bioengineering and to build new scientific interactions across the field.

Related Meeting

This GRC was held in conjunction with the "Musculoskeletal Biology and Bioengineering" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Cross-Disciplinary Innovations in Musculoskeletal Biology and Bioengineering
This session will introduce the theme of our meeting (Stepping Across Disciplines to Spur Innovation) and to provide examples of the fruition of such cross-disciplinary interactions through two keynotes drawn from thought leaders in our field.
Discussion Leaders: Robert Mauck (University of Pennsylvania, USA) and Peter Johnson (MedSurgPI, LLC, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:25 pmFarshid Guilak (Washington University in St. Louis, USA)
"Engineering New Biologic Therapies for Arthritis"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmThomas Clemens (Johns Hopkins University, USA)
"Role of Sensory Nerves in Skeletal Development and Repair"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGrowth and Development
This session will highlight the latest advances in musculoskeletal developmental biology across tissue types. In this session, we will define and discuss the most important advances in this discipline over the last several years. Dr. Ronen Schweitzer (OHSU), our GRS Keynote Speaker, will serve as discussion leader.
Discussion Leader: Ronen Schweitzer (Shriners Research Center, Portland, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amGabrielle Kardon (University of Utah, USA)
"Of Mice and Men: The Role of Tbx3 in Development of a Subset of Forelimb Bones, Muscles and Their Attachment Sites"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amJenna Galloway (Harvard Medical School, USA)
"Tendon Development and Regeneration: Gaining New Insights from the Zebrafish"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amThomas Lozito (University of Pittsburgh, USA)
"Cellular Origins of Regenerated Lizard Tail Musculoskeletal Tissues"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amYingzi Yang (Harvard School of Dental Medicine, USA)
"Gas Signaling Inhibits Bone Formation in Soft Tissues by Suppressing Hedgehog Signaling"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmElazar Zelzer (Weizmann Institute of Science, Israel)
"Monosynaptic Stretch Reflex Circuit Masterminds Skeletal Regeneration and Homeostasis"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJessica Lehoczky (Brigham and Women's Hospital, USA)
"Lgr6 Marks Nail Stem Cells and Is Required for Digit Tip Regeneration"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMulti-Scale Tissue Structure and Function
This session will highlight the latest advances in multi-scale tissue structure and function, to specifically delve into how our basic understanding is informed by studies that transit from the macro-scale to the nano-scale, and to discuss how this new understanding informs both basic and clinical science. Dr. Dawn Elliott (University of Delaware) will serve as discussion leader.
Discussion Leader: Dawn Elliott (University of Delaware, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmSilvia Salinas Blemker (University of Virginia, USA)
"Multi-Scale Modeling of Skeletal Muscle Structure and Function with Application to Muscle Disease"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmKarl Kadler (University of Manchester, United Kingdom)
"Circadian Clock Regulation of the Major Systems Controlling Matrix Protein Secretion and Turnover"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmAlan Grodzinsky (Massachusetts Institute of Technology, USA)
"Aggrecan Nanomechanics: Relevance to Cartilage Function and Drug Delivery in PTOA"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmMalin Hammerman (Linköping University, Sweden)
"Mechanical Loading Stimulates Early Tendon Healing in Rats via Microdamage"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEndogenous Stem Cells and Their Microenvironment
This session will identify what precisely defines the microenvironment and what inputs regulate its modulation during development and in disease processes. We will also discuss endogenous stem cells within these microenvironmental niches, and their role in tissue homeostasis, regeneration, and repair. Dr. Johnny Huard (Steadman Philippon Research Institute/University of Texas Health Science Center at Houston) will serve as discussion leader.
Discussion Leader: Johnny Huard (University of Texas Health Science Center, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amBenjamin Alman (Duke University, USA)
"The Rejuvenation of Fracture Repair: It's All in the Blood"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amChristopher Evans (Mayo Clinic, USA)
"Genetic Modification of Endogenous Stem Cells Within Their Microenvironment"
10:15 am - 10:30 amDiscussion
10:30 am - 10:40 amFoteini Mourkioti (University of Pennsylvania, USA)
"Stem Cell Regulation in Muscular Dystrophy"
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:40 amBruno Peault (University of California, USA / University of Edinburgh, United Kingdom)
"A Hierarchy of Innate Mesenchymal Stem Cells Within Blood Vessel Walls"
11:40 am - 11:55 amDiscussion
11:55 am - 12:05 pmGuak Kim Tan (Shriners Hospitals for Children, USA)
"Stem/Progenitor Cell Recruitment to Deteriorating Tendons in Mice with Conditional Deletion of TGF-Beta Type II Receptor"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMolecular Tools to Manipulate the Cellular Program
Advances in both basic science knowledge and development of new treatment paradigms require the incorporation of cutting-edge technology. The goal of this session will be to discuss and introduce new tools to measure and manipulate the cellular program to map and direct cell fate (reprogramming) and to tune function (CRISPR/Cas technologies) in the context of musculoskeletal regeneration and repair. Dr. Matt Warman (Harvard University) will serve as discussion leader.
Discussion Leader: Matthew Warman (Boston Children's Hospital, Harvard University, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmCharles Gersbach (Duke University, USA)
"Genome and Epigenome Editing for Gene Therapy and Functional Genomics"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmApril Craft (Boston Children's Hospital, Harvard University, USA)
"Directed Differentiation of Human Pluripotent Stem Cells into Functionally Distinct Articular and Growth Plate-Like Cartilage Tissues"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmAndres Garcia (Georgia Institute of Technology, USA)
"Biofunctional Hydrogels for Bone Repair"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmAmbika Bajpayee (Langer Lab, Massachusetts Institute of Technology, USA)
"Sustained Intra-Articular Delivery of Corticosteroids Using Avidin, a Cationic Protein, as a Drug Carrier to Prevent Post-Traumatic Osteoarthritis"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMaterials to Construct the Microenvironment
In addition to technologies focused on the cellular program, it is essential to innovate in the development of artificial microenvironments and tissue equivalents to probe regeneration and disease processes. This session will focus on novel construction methods to create and modify the cellular microenvironment, including novel material and mechanical designs that approximate normal tissue physiology and pathophysiology. Dr. Jason Burdick (University of Pennsylvania) will serve as discussion leader.
Discussion Leader: Jason Burdick (University of Pennsylvania, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amDavid Kaplan (Tufts University, USA)
"Tissue Engineering - A Look to the Future"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amStephanie Bryant (University of Colorado, USA)
"A Combined Experimental and Computational Approach to Designing Personalized Hydrogels"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amBrendan Harley (University of Illinois at Urbana-Champaign, USA)
"Composite Biomaterials for Craniofacial and Osteotendinous Repair"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amDaniel Kelly (Trinity College Dublin, Ireland)
"Engineering the Microenvironment for Bone and Joint Regeneration"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmMolly Stevens (Imperial College London, United Kingdom)
"New Biomaterials Approaches for Bone and Cartilage Repair"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmAmy McNulty (Duke University Medical Center, USA)
"Characterization of Meniscus Derived Matrix and Evaluation for Repair of the Meniscus"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMulti-Scale Mechanobiology in Health and Disease
It is well appreciated that mechanobiology is central to both normal tissue growth and development as well as to multiple disease processes across the musculoskeletal system. The goal of this session is to identify and discuss recent advances in our understanding of the mechanisms by which cells sense mechanical perturbations and the role of altered sensation in pathologic scenarios, as well as the application of this knowledge towards the treatment of disease. Dr. Tamara Alliston (UCSF) will serve as discussion leader.
Discussion Leader: Tamara Alliston (University of California, San Francisco, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmBoris Hinz (University of Toronto, Canada)
"Don't Stress - The Mechanobiology of Tissue Repair"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmJan Lammerding (Cornell University, USA)
"Using Microfluidics Microfabrication to Study Nuclear Mechanics and Mechanotransduction"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmViola Vogel (ETH Zurich, Switzerland)
"From the Extracellular Matrix to the Nucleus"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmBrian Cosgrove (University of Pennsylvania, USA)
"N-Cadherin Adhesive Interactions Modulate ECM Mechanosensing and Fate Commitment in Mesenchymal Stem Cells"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmModel Systems to Study MSK Injury, Repair, and Regeneration
The transition to translation begins with model systems. These may start as a simple system in which to test a new therapy in a surgical model, but ultimately need to be realized in the context of complex and often pathologic scenarios. In this session, we will discuss current models of musculoskeletal tissue injury, repair, and regeneration and identify commonalities in study design that enable the more faithful recapitulation of the scenario in which repair occurs so as to increase the probability of clinical translation. Dr. Chungfeng Zhao (Mayo Clinic) will serve as discussion leader.
Discussion Leader: Chunfeng Zhao (Mayo Clinic, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amAmy Wagers (Harvard University, USA)
"Targeting Muscle Stem Cells for Regenerative Medicine"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amHani Awad (University of Rochester, USA)
"Manipulating Protease Activity for Scarless Flexor Tendon Healing in Mice"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amAlice Huang (Icahn School of Medicine at Mount Sinai, USA)
"Regulation of Tendon Regeneration and Scar Formation"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amKurt Hankenson (Michigan State University, USA)
"The Essential Role of Vascularization During Bone Regeneration: Animal and Computational Models"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmFergal O'Brien (Royal College of Surgeons in Ireland, Ireland)
"Natural Polymer-Based Scaffolds as Platform Systems for the Delivery of Therapeutics to Promote Enhanced Bone, Cartilage and Osteochondral Tissue Repair"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmKyle Allen (University of Florida, USA)
"Magnetic Capture of Osteoarthritis Biomarkers in the Rat"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmConfounders of Regeneration: Aging, Inflammation, Fibrosis, and Other Factors
While in the previous session we discussed models of musculoskeletal repair, this session will turn its attention to systemic matters, and how these broader factors impact the process of tissue injury, repair, and regeneration. This will include inputs from not just multiple interacting musculoskeletal tissues, but also multiple organ systems that impact disease progression and repair potential. To end the conference, we will particularly focus here on studies that are by their very nature multi-disciplinary, crossing numerous tissue types and organ systems to provide a wider perspective on musculoskeletal biology, bioengineering, repair, and regeneration. Dr. Nadeen Chahine (Feinstein Institute) will serve as discussion leader.
Discussion Leader: Nadeen Chahine (The Feinstein Institute for Medical Research, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmJames Iatridis (Icahn School of Medicine at Mount Sinai, USA)
"Injury, Inflammation, and Altered Mechanotransduction in the Intervertebral Disc"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmBeth Winkelstein (University of Pennsylvania, USA)
"Moving (or Removing) the Needle for Improved Pain Treatments"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmBrian Diekman (University of North Carolina at Chapel Hill, USA)
"Transcriptional Regulation of the Aging Biomarker p16INK4a and its Role in Mediating Chondrocyte Senescence During Osteoarthritis"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmChristopher Hernandez (Cornell University, USA)
"Disruption of the Gut Microbiome Impairs Bone Strength and Tissue Material Properties in Mice"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by (1R13AR070005-01) from the National Institute of Arthritis And Musculoskeletal And Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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