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Carbohydrates
Gordon Research Conference

Chemical and Biochemical Approaches to Deciphering Glycan Functions

Dates

June 25-30, 2017

Location

Mount Snow
West Dover, VT Site Information

Organizers

Chair:
Lai-Xi Wang

Vice Chairs:
Zhongwu Guo & Xi Chen

Application Deadline

Applications for this meeting must be submitted by May 28, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

Advances in carbohydrate chemistry and glycobiology have revealed diverse roles and functions of glycans in a number of important physiological and disease processes. Yet a vast chemical and functional space of glycans remains to be explored, and we have just begun to decode the glycomes of living species. The main goal of the Gordon Research Conference on Carbohydrates is to bring together an outstanding and diverse group of scientists who work at the frontiers of basic and translational glycoscience to discuss their recent work and to explore the next frontiers in the field. This meeting will emphasize the interplay of chemistry, biology, biotechnology and medicine with a focus on molecular approaches to deciphering glycan functions. The meeting provides a unique platform and a collegial environment to foster the interactions among graduate students, postdoctoral fellows, junior and established scientists to discuss the latest findings and to exchange ideas in this multidisciplinary field. The scientific sessions will cover diverse areas of the field, including fundamental research in synthetic and analytic carbohydrate chemistry, recent developments of enabling technologies for functional glycomics, the molecular understanding of protein-carbohydrate interactions, the development of carbohydrate-based therapeutic agents and glycoconjugate vaccines, and the exploration of specific glycan recognition for bio-medicine. The core of this Carbohydrates GRC will consist of about 27 invited talks and 20-25 short talks (selected from abstracts), along with highly interactive poster sessions. In addition, the inaugural Carbohydrate Gordon Research Seminar (GRS) will be held just prior to the Carbohydrates GRC. The Carbohydrate GRS will provide a collegial environment for a growing number of younger scientists (graduate students, postdocs, junior faculty members etc) in glycoscience to disseminate scientific information related to the field, establish scientific network, discuss potential collaborations, and gain confidence towards participation and contribution to the dialogue in the following GRC.

Related Meeting

This GRC will be held in conjunction with the "Carbohydrates" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEnabling Technologies for Functional Glycomics
Discussion Leader: Joseph Barchi (National Cancer Institute, NIH, USA)
7:40 pm - 8:05 pmRichard Cummings (Beth Israel Deaconess Medical Center, Harvard Medical School, USA)
"Human Glycomics and Deciphering the Expression and Biological Recognition of Glycans"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmNicola Pohl (Indiana University, USA)
"A Systems Approach to Carbohydrate Synthesis and Analysis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmJeffrey Gildersleeve (National Cancer Institute, NIH, USA)
"Exploiting Anti-Glycan Immunity to Improve Cancer Care"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGlycosylation and Synthetic Methodology
Discussion Leaders: Geert-Jan Boons (University of Georgia, USA) and Biao Yu (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China)
9:00 am - 9:25 amAlexei Demchenko (University of Missouri-St. Louis, USA)
"From Stereocontrolled Glycosylation to the Automated Oligosaccharide Synthesis"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amAntony Fairbanks (The University of Canterbury, New Zealand)
"Protecting Group Free Transformations of Reducing Sugars in Aqueous Solution"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amShort Talk Selected from Poster Abstracts
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amYasuhiro Kajihara (Osaka University, Japan)
"Synthesis of Glycoconjugates for Elucidation of Oligosaccharide Functions"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amShang-Cheng Hung (Academia Sinica, Taiwan)
"Synthesis and Characterization of Specific Heparan Sulfate-Protein Interactions"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChemical Glycobiology
Discussion Leader: Xi Chen (University of California, Davis, USA)
7:30 pm - 7:55 pmLinda Hsieh-Wilson (California Institute of Technology, USA)
"Carbohydrate Recognition and Signaling in the Brain"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmJames Paulson (The Scripps Research Institute, USA)
"Human Influenza Virus Receptors"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmJennifer Kohler (University of Texas Southwestern Medical Center, USA)
"Discovery of Host Cell Glycans Recognized by Bacterial Toxins"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEnzymatic and Chemoenzymatic Assembly of Glycans
Discussion Leader: Peng George Wang (Georgia State University, USA)
9:00 am - 9:25 amHung-Wen Liu (University of Texas at Austin, USA)
"Biosynthetic Studies of Oxetanocin A"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amVladimir Kren (Czech Academy of Sciences, Czech Republic)
"Mutant Glycosyltransferases and Hexosaminidases in the Synthesis of Advanced Glycomaterials"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amShort Talk Selected from Poster Abstracts
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amJian Liu (University of North Carolina at Chapel Hill, USA)
"Developing an Enzyme-Based Approach to Synthetize Glycosaminoglycans"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amStephen Withers (University of British Columbia, Canada)
"Discovering New Glycosidases Through Metagenomics and Gene Synthesis"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMolecular Recognition in Protein-Carbohydrate Interactions
Discussion Leaders: Xing Chen (Peking University, China) and Lara Mahal (New York University, USA)
7:30 pm - 7:55 pmAnne Imberty (CERMAV, CNRS, France)
"Microbial Lectins Binding to Lewis Glycotopes: Experimental and Computational Study"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmRobert Sackstein (Harvard Medical School, USA)
"Glycosyltransferases as Tools to Identify Cell Surface Lactosaminyl Glycans"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmPeng Wu (Scripps Research Institute, USA)
"Chemoenzymatic Detection of Glycans: Methods and Applications"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCarbohydrate Vaccines
Discussion Leaders: Xuefei Huang (Michigan State University, USA) and Steven Sucheck (The University of Toledo, USA)
9:00 am - 9:25 amPeter Seeberger (Max-Planck-Institute of Colloids and Interfaces, Germany)
"From Biologicals to Pharmaceuticals: A Medicinal Chemistry Approach to Carbohydrate-Conjugate Vaccines Against Streptococcus pneumoniae and Other Bacteria"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amYan-Mei Li (Tsinghua University, China)
"Glycopeptide Vaccines for Cancer Immunotherapy"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amShort Talk Selected from Poster Abstracts
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amMax Crispin (University of Oxford, United Kingdom)
"The Glycan Shield of HIV-1 and Immunogen Design"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amPeter Andreana (University of Toledo, USA)
"An Entirely Carbohydrate-Recognizing Monoclonal Antibody"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStructural Chemistry and Biology of Carbohydrates
Discussion Leader: Zhongwu Guo (University of Florida, USA)
7:30 pm - 7:55 pmRobert Woods (University of Georgia, USA)
"Computational and Biophysical Insight into Glycan Specificity: The Role of Entropy and Avidity"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmYuriy Knirel (N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Russia)
"Capsular Polysaccharides of the Nosocomial Pathogen Acinetobacter baumannii: Structure, Genetics, Biosynthesis, and Cleavage"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmCatherine Costello (Boston University, USA)
"Can Advances in Mass Spectrometry Unlock the Mysteries of Glycans?"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmSynthetic Probes for Deciphering Carbohydrate Functions
Discussion Leader: George O'Doherty (Northeastern University, USA)
9:00 am - 9:25 amYukishige Ito (RIKEN, Japan)
"Synthetic Substrates for the Analysis of Glycan Processing Enzymes in the ER"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amTodd Lowary (University of Alberta, Canada)
"Synthesis of Designer Polysaccharides"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amShort Talk Selected from Poster Abstracts
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amEriks Rozners (Binghamton University, USA)
"Carbohydrate Chemistry for RNA Interference: Synthesis, Structure and Biological Activity of Amide-Linked RNA"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amShort Talk Selected from Poster Abstracts
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk Selected from Poster Abstracts
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGlycans in Biotechnology and Medicine
Discussion Leader: Philip Deshong (University of Maryland, College Park, USA)
7:30 pm - 7:55 pmShin-Ichiro Nishimura (Hokkaido University, Japan)
"Nanomedicine Targeting Intracellular Glycoenzymes"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmCarlos Bosques (Momenta Pharmaceuticals, Inc., USA)
"Leveraging Sialylation in the Development of Potent Anti-Inflammatory Therapies"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmJohn Magnani (GlycoMimetics, Inc., USA)
"Three Different Glycomimetic Drugs in Clinical Trials for Inflammatory Disorders and Cancer"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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