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Cardiac Regulatory Mechanisms
Gordon Research Conference

Atoms to Omics – New Approaches to Understand and Treat Cardiac Disease

Dates

June 5-10, 2016

Location

Colby-Sawyer College
New London, NH

Organizers

Chairs:
Bjorn C. Knollmann & Barbara Casadei

Vice Chairs:
Brian O'Rourke & Thomas Eschenhagen

Meeting Description

As in its over 25 year history, the 2016 Gordon Research Conference (GRC) on Cardiac Regulatory Mechanisms again will bring together new scientists and established investigators with a common interest in elucidating regulatory mechanisms of the normal heart and how they become dysfunctional in disease. The informal nature of the GRC is unique in fostering discussions that span disciplines and geography, and enables new personal and scientific connections to develop. The GRC setting sets the stage for significant exchange of the latest unpublished research and routinely proves to be a source of new collaborative research among basic and clinical scientists that will help promote translation of basic findings to clinical treatment. Importantly, the venue and tradition of this GRC, its emphasis on full participation and discussions, and its inclusion of mature and young investigators also ensures vestment of the next generation in these issues and continuity in the information flow. The GRC will be preceded by a 2 day Gordon Research Seminar (GRS) exclusively for graduate students and post-doctoral trainees.

The 2016 meeting focuses on cutting edge approaches that range from the atomic scale to the use of "big data" to help understand cardiac function in health and disease. Speakers will present the latest advances in the core areas of the field such as myofilament function, mitochondrial regulation, redox signaling, Ca signaling, myocyte-non-myocyte cross talk, and the molecular regulation of myocardial remodeling. The program also covers select translational topics such as cardiac regeneration and rejuvenation and the mechanisms underlying atrial fibrillation that are of ongoing scientific controversies. The invited speakers represent a broad mix of young emerging scientists and established leaders of diverse scientific background, geographic and gender who will present not only their latest findings, but also highlight the knowledge gaps in the field. The session chairs are established scientific leaders who have been charged to promote a lively and interactive atmosphere during the invited talks and at the poster sessions. The program is complemented by additional talks selected from the poster submissions.

Related Meeting

This GRC was held in conjunction with the "Cardiac Regulatory Mechanisms" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCardiac Repair and Regeneration
Discussion Leaders: Mark Sussman (San Diego State University, USA) and Charles Hong (Vanderbilt University Medical Center, USA)
7:40 pm - 8:00 pmCharles Murry (University of Washington, USA)
"Cardiac Regeneration Using Pluripotent Stem Cells in Large Animals"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmKai Wollert (Hannover Medical School, Germany)
"Emerging Protein- and Small Molecule-Based Therapies for Cardiac Repair"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmWolfram Zimmerman (University Medical Center Gottingen, Germany)
"Engineering Heart Repair"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmT.K. Feaster (Vanderbilt University, USA)
"Making Better Human iPSC-Derived Cardiomyocytes"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMitochondrial Function, Redox Signaling and Calcium Handling
Discussion Leaders: Asa Gustafsson (University of California, San Diego, USA) and Elizabeth Murphy (National Heart, Lung, and Blood Institute, NIH, USA)
9:00 am - 9:20 amChristoph Maack (Universitätsklinikum des Saarlandes, Germany)
"Mitochondrial Energetics and Calcium Coupling in the Heart"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amNatalia Shirokova (New Jersey Medical School / Rutgers University, USA)
"Mitochondrial Dysfunction During Progression of Dystrophic Cardiomyopathy"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amJennifer Kwong (Cincinnati Children's Hospital Medical Center, USA)
"Matching Cardiac Workload with ATP Production: Role of the Mitochondrial Ca2+ Uniporter"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amMoshi Song (Washington University School of Medicine, USA)
"Mitochondrial Dynamism in the Heart"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMichael Murphy (Mitochondrial Biology Unit, University of Cambridge, United Kingdom)
"Mechanisms of Mitochondrial ROS Production in the Heart as Therapeutic Targets"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Stephen Hurst (Thomas Jefferson University, USA)
"Truncation of GSK-3 Beta in the Mitochondria Matrix Is the Master Switch of the mPTP"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Ricardo Carnicer (University of Oxford, United Kingdom)
"Protection Against Diabetic Cardiomyopathy: New Roles for BH4 and NO in the Heart"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCardiac Ageing and Rejuvenation
Discussion Leaders: Martin Morad (Medical University of South Carolina, USA) and Walter Koch (Temple University, USA)
7:30 pm - 7:50 pmMichael Ristow (Energy Metabolism Laboratory, ETH Zurich, Switzerland)
"Mitohormesis in Aging"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmRichard Lee (Brigham and Women's Hospital, USA)
"Molecular Regulation of Cardiac Aging"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSatchidananda Panda (Salk Institute for Biological Studies, USA)
"Time Restricted Feeding for Alleviation of Cardiac Disease"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Christopher Traynham (Temple University, USA)
"Loss of Endogenous Negative Regulation of GRK2 by S-Nitrosylation at Cysteine 340 Leads to Cardiovascular Dysfunction with Aging"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Ronald Vagnozzi (Cincinnati Children's Hospital Medical Center, USA)
"Dual-Reporter Genetic Lineage Tracing to Assess the Paracrine Hypothesis of Cell Therapy for the Heart"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulation of Myofilament Function in Health and Disease
Discussion Leaders: John Solaro (University of Illinois at Chicago, USA) and Jill Tardiff (University of Arizona, USA)
9:00 am - 9:20 amDavid Warshaw (University of Vermont College of Medicine, USA)
"MyBP-C: Stepping on the Gas and Brake Simultaneously to Regulate Cardiac Contractility"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSakthivel Sadayappan (Loyola University Chicago, USA)
"New Insights into the Role of MYBPC3 in Cardioprotection During Ischemia-Reperfusion Injury"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJolanda Van Der Velden (VU University Medical Center, The Netherlands)
"Myofilament (Dys)function in HCM"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amGroup Photo / Coffee Break
11:00 am - 11:10 amAldrin Gomes (University of California, Davis, USA)
"Proteasome (Dys)function in HCM"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amDan Beard (University of Michigan, USA)
"Multi-Scale Modeling of Cardiac Energy Metabolism and Coronary Flow"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amSabine Huke (Vanderbilt University, USA)
"Myocyte-Vascular Cross Talk in HCM"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmBenjamin Prosser (University of Pennsylvania, USA)
"Microtubule Role in Myocyte Mechanics"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Juan Bernal (Spanish National Centre for Cardiovascular Research (CNIC), Spain)
"Genetic Changes During Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Development"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell to Cell Cross-Talk in the Heart
Discussion Leaders: Burns Blaxall (Cincinnati Children's Hospital Medical Center, USA) and Paula Da Costa-Martins (Maastricht University, The Netherlands)
7:30 pm - 7:50 pmMatthias Nahrendorf (Massachusetts General Hospital, USA)
"Inflammatory Networks in Ischemic Heart Disease"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmStefan Engelhardt (Technische Universität München, Germany)
"Myocytes and Fibroblasts"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMarco Mongillo (University of Padova, Italy)
"Myocytes and Neurons"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmCharalambos Antoniades (University of Oxford, United Kingdom)
"Adipose Tissue and Myocardium"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Mechanism of Atrial Fibrillation
Discussion Leaders: Dobromir Dobrev (University of Duisburg-Essen, Germany) and Donald Bers (University of California, Davis, USA)
9:00 am - 9:20 amPepe Jalife (University of Michigan, USA)
"Atrial Fibrosis – Culprit or Bystander in Atrial Fibrillation?"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSander Verheule (Maastricht University, The Netherlands)
"Metabolic Impact of AF"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amLarissa Fabritz (Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom)
"Does PITX2-Dependent Gene Regulation Promote Atrial Fibrillation?"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMaura Greiser (University of Maryland, USA)
"Calcium Silencing in AF"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amXander Wehrens (Baylor College of Medicine, USA)
"Calcium Triggering in AF"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Leonardo Sacconi (European Laboratory for Non-Linear Spectroscopy, Italy)
"Measuring Electrical Conductibility of Cardiac T-Tubular System"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Przemyslaw Radwanski (The Ohio State University, USA)
"Neuronal Na+ Channels in Conjunction with Na+/Ca+ Exchange Act as an Arrhythmogenic Trigger in Two Genetic Models of Calcium-Dependent Atrial Arrhythmias"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCalcium Signaling and EC Coupling
Discussion Leaders: Wayne Chen (University of Calgary, Canada) and Alicia Mattiazzi (Cardiovascular Research Center, National University of La Plata, Argentina)
7:30 pm - 7:50 pmFilip Van Petegem (University of British Columbia, Canada)
"Structural Insights into the Architecture and Ligand Binding Properties of Ryanodine Receptors"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmDavid Eisner (University of Manchester, United Kingdom)
"Regulation of Diastolic Calcium"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmYe Chen-Izu (University of California, Davis, USA)
"Mechano-Chemo-Transduction During Cardiomyocyte Contraction"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmGil Bub (University of Oxford, United Kingdom)
"Dye-Free Optical Mapping and Optogenetic Control of Excitation Waves"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Andriy Belevych (The Ohio State University, USA)
"The Role of Junctional- and Non-Junctional Ca Release Sites in the Generation of Arrhythmogenic Diastolic Ca Release in Myocytes from Failing Hearts"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Catherine Makarewich (University of Texas Southwestern Medical Center, USA)
"DWORF: A Novel Muscle Specific Micropeptide that Enhances SERCA Activity and Myocyte Contractility"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Signaling in Myocardial Remodeling
Discussion Leaders: Lucie Carrier (University Medical Center Hamburg-Eppendorf, Germany) and Jeffery Molkentin (Cincinnati Children's Hospital, USA)
9:00 am - 9:20 amPaula Da Costa-Martins (Maastricht University, The Netherlands)
"Non-Coding RNA Regulation of Myocardial Hypertrophy"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amThomas Braun (Max-Planck-Institute for Heart and Lung Research, Germany)
"The Role of Dedifferentiated Cardiomyoctes in the Diseased Myocardium"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJennifer Davis (University of Washington, USA)
"Master Regulators of Cardiac Fibroblast Activation"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amSarah Franklin (University of Utah, USA)
"Epigenetic Mechanisms Regulating Chromatin Structure in the Heart"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amRoger Hajjar (Icahn School of Medicine at Mount Sinai, USA)
"SERCA2a and Beyond"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Ulrike Mende (Rhode Island Hospital / Brown University, USA)
"Regulation of Cardiomyocyte Electrical Activity by Cardiac Fibroblasts in Innovative 3D In Vitro Cellular Cross-Talk Platforms"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Kevin Bersell (Vanderbilt University, USA)
"Genome Editing in iPSCs Establishes that a Rare TBX5 Variant Causes the Brugada Syndrome"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Harnessing Big Data for Basic Discovery
Discussion Leaders: Thomas Eschenhagen (University Medical Center Hamburg Eppendorf, Germany) and Brian O'Rourke (Johns Hopkins University, USA)
7:30 pm - 7:50 pmPatrick Ellinor (Massachusetts General Hospital / Broad Institute, USA)
"Making Functional Sense of GWAS Data"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmDan Roden (Vanderbilt University Medical Center, USA)
"Phenome-Wide Association Studies - From Patients to Molecules"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:15 pmChristine Seidman (Harvard Medical School, USA)
"New Discoveries in Human Cardiomyopathies"
9:15 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible, in part by1R13AG054044-01 from National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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