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Cell Contact and Adhesion
Gordon Research Conference

Cell Contact as a Master Regulator of Membrane Organization, Mechanics and Signaling

Dates

June 18-23, 2017

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Andrea McClatchey

Vice Chair:
Andrew J. Ewald

Meeting Description

The 2017 Gordon Research Conference (GRC) on Cell Contact & Adhesion (CC&A) and associated Gordon Research Seminar (GRS) for graduate students and postdoctoral fellows will be held from June 17-23 at Proctor Academy, Andover, NH. The GRC has been held biannually since 1973 and has led both scientific progress and the training/mentoring pipeline of young scientists in the field. In work often presented in unpublished form at the CC&A GRC, the CC&A community has driven an appreciation of the complex and dynamic nature of cell contacts and their central role in guiding many cell behaviors such as polarity, signaling and mechanics and in driving human disease, particularly cancer. The scientific and social themes of the 2017 meeting seek to build unity in both the science of cell contacts and within the CC&A community. This will be achieved by communicating unpublished data, nucleating innovative multidisciplinary collaborations, defining community standards that enhance the rigor and reproducibility of cell adhesion experiments and mapping strategies for community-driven support for trainees/future scientific leaders.

Cell-cell contacts were initiating elements in the evolution of multicellular life forms. The 2017 CC&A GRC scientific program reflects the central role of cell contacts in complex biologies, building from new proteomic, imaging, computational and engineering approaches that are driving an unprecedented view of the molecular composition and dynamic nature of cell junctions, to ways that cell contacts guide polarity, mechanics and signaling within individual or neighboring cells, to studies of how communication among many cells governs morphogenesis, homeostasis and diseases of multicellular tissues. At every step the program will highlight new technologies, tools and approaches, while spotlighting the talent of young investigators.

Related Meeting

This GRC was held in conjunction with the "Cell Contact and Adhesion" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Advancing the Field: Using New Technologies to Understand How Cell Contact Coordinates Signaling and Tissue Organization In Vivo
Discussion Leader: Andrea McClatchey (Massachusetts General Hospital / Harvard Medical School, USA)
7:40 pm - 7:55 pmOpening Remarks
7:55 pm - 8:40 pmJay Rajagopal (Massachusetts General Hospital, USA)
"Notches, Niches and Plasticity"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmLate-Breaking Topic
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion: Pushing the Field Forward: Tools, Knowledge Gaps and Training
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEstablishing Cell-Cell Contact: Molecular Composition
Discussion Leader: Andrew Ewald (Johns Hopkins University School of Medicine, USA)
9:00 am - 9:20 amWilliam Weis (Stanford University, USA)
"Force-Dependent Molecular Interactions in Adherens Junction Assembly"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amChristina Van Itallie (National Heart, Lung, and Blood Institute, NIH, USA)
"Dynamic Protein Interactions in Tight Junction Formation and Maintenance"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:40 amBrian Belardi (University of California, Berkeley, USA)
"Building the Tight Junction: Probing the Assembly and Regulation of Membrane Interface Organization Through In Vitro Reconstitution"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amDelphine Delacour (Institut Jacques Monod, CNRS, France)
"EpCAM Ensures Correct Epithelial Cell Adhesion and Organization"
10:55 am - 11:00 amDiscussion
11:00 am - 11:20 amKathleen Green (Northwestern University, USA)
"Evolutionary Repurposing of Cadherins to Diversify Tissue Functions"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amPierre-Francois Lenne (Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille University / CNRS, France)
"Shaping Cell Contacts During Tissue Morphogenesis"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmAnna Seybold (Buchmann Institute of Molecular Life Science, Goethe University Frankfurt, Germany)
"Cryo-Electron Tomography on Desmosomes Isolated From the Mouse Liver"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmRyan Baumert (University of Texas MD Anderson Cancer Center, USA)
"Revealing a Novel Switch-Like Function of Delta-Catenin in Dendrite Development"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Cara Gottardi (Northwestern University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEstablishing Cell-Cell Contact: Imaging/Modeling
Discussion Leader: Andrew Kowalczyk (Emory University, USA)
7:30 pm - 7:50 pmTatyana Svitkina (University of Pennsylvania, USA)
"Ultrastructural Analysis of the Cytoskeleton at Cell-Cell Contacts"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmPakorn Kanchanawong (National University of Singapore, Singapore)
"Nanoscale Architecture of Cadherin-Based Cell Adhesions"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKatie Bentley (Beth Israel Deaconess Medical Center / Harvard Medical School, USA)
"Modeling Differential Adhesion in Angiogenesis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmTalk Selected from the GRS
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion: Pushing the Field Forward: Tools, Knowledge Gaps and Training
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmImpact of Cell-Cell Contacts: Mechanical
Discussion Leader: Kathleen Green (Northwestern University, USA)
9:00 am - 9:20 amPatrick Oakes (University of Rochester, USA)
"Zyxin Mediates Mechanochemical Feedback to Regulate Cell Elasticity"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAdam Martin (Massachusetts Institute of Technology, USA)
"Actomyosin Meshwork Mechanosensing Enables Tissue Shape to Orient Force"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amChristopher Chen (Boston University / Wyss Institute for Biologically Inspired Engineering, Harvard University, USA)
"Forces and Mechanotransduction in 3D Vascular Biology"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amAlpha Yap (University of Queensland, Australia)
"Junctional Mechanotransduction and Epithelial Homeostasis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amKen Irvine (Waksman Institute of Microbiology, Rutgers University, USA)
"Regulation of Hippo Signaling by Cytoskeletal Tension"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmDaniel Conway (Virginia Commonwealth University, USA)
"Mechanical Force Across E-Cadherin Regulates Epithelial Acini Homeostasis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTalk Selected from the GRS
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImpact of Cell-Cell Contacts: Polarity and Signaling
Discussion Leader: Alpha Yap (University of Queensland, Australia)
7:30 pm - 7:50 pmDavid Bryant (Cancer Research UK Beatson Institute, United Kingdom)
"Functional Genomic Dissection of ARF GTPases in Polarized Invasion"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJames Salzer (New York University School of Medicine, USA)
"How Axo-Glial Interactions Direct the Formation of the Domains of Myelinated Axons"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJeffrey Axelrod (Stanford University School of Medicine, USA)
"Planar Cell Polarity Modulates Primary and Metastatic Tumor Cell Behavior in Drosophila"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSergio Simoes (University of Toronto, Canada)
"Actomyosin Contractility and Apical Trafficking Drive Epithelial Cell Ingression"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion: Pushing the Field Forward: Tools, Knowledge Gaps and Training
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCommunication Among Cells via Contacts: Principles and Homeostasis
Discussion Leader: Christopher Chen (Boston University / Wyss Institute for Biologically Inspired Engineering, Harvard University, USA)
9:00 am - 9:20 amRoberto Mayor (University College London, United Kingdom)
"Front and Rear Forces During Collective Cell Migration"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAnn Miller (University of Michigan, USA)
"Cell-Cell Junction Remodeling in Dividing Epithelial Cells"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amCarien Niessen (University of Cologne, Germany)
"Cadherin-Dependent Tissue Polarization in Morphogenesis and Homeostasis"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amSally Horne-Badovinac (University of Chicago, USA)
"Planar Cell-Cell Signaling Controlling Collective Cell Migration"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJennifer Zallen (Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Center, USA)
"Signals and Forces that Control the Dynamics of Multicellular Systems"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmAlex Hughes (University of California, San Francisco, USA)
"Reconstituting Tissue Folding Through Programmed Cell Traction Networks"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMartijn Gloerich (University Medical Center Utrecht, The Netherlands)
"Coupling the Orientation of Cell Division to Cell-Cell Adhesion by the Mechano-Sensitive E-Cadherin/LGN Complex"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCommunication Among Cells via Contacts: Morphogenesis
Discussion Leader: Cara Gottardi (Northwestern University, USA)
7:30 pm - 7:50 pmMark Peifer (University of North Carolina at Chapel Hill, USA)
"Building the Body Plan - The Miracle of Morphogenesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmChristin Kuo (Stanford University, USA)
"Formation of a Neurosensory Organ by Epithelial Cell Slithering"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDouglas Desimone (University of Virginia, USA)
"Mechanical Coupling of Cells in the Assembly and Morphogenesis of Tissues at Gastrulation"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmAbigail Kindberg (University of California, San Francisco, USA)
"Cellular Mechanisms of Eph/Ephrin Mediated Cell Segregation and Boundary Formation in Development"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion: Pushing the Field Forward: Tools, Knowledge Gaps and Training
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDefective Cell Contacts in Human Disease
Discussion Leader: Carien Niessen (University of Cologne, Germany)
9:00 am - 9:20 amCara Gottardi (Northwestern University, USA)
"Roles for the Developmentally Redundant AlphaT-Catenin in Asthma and Autism"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMatthew Tyska (Vanderbilt University School of Medicine, USA)
"Regulation of Brush Border Assembly Dynamics by Intermicrovillar Adhesion"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amAndrew Kowalczyk (Emory University, USA)
"Greasing the Wheels of Desmosome Assembly: An Essential Role for Lipid Raft Membrane Domains in Desmosomal Adhesion and Disease"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMartin Schwartz (Yale School of Medicine, USA)
"Cell-Cell Adhesion Receptors in Vascular Mechanotransduction"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSharon Cooper (Ohio State University, USA)
"The Mechanism of Protocadherin-19 Mediated Adhesion and Its Role in Brain Morphogenesis and Female Epilepsy"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amAdam Kwiatkowski (University of Pittsburgh School of Medicine, USA)
"Vinculin and Afadin Couple Actin to the Adherens Junction in Cardiomyocytes"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmTalk Selected from the GRS
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion: Pushing the Field Forward: Tools, Knowledge Gaps and Training
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell Contacts in Cancer Development and Progression
Discussion Leader: Mark Peifer (University of North Carolina at Chapel Hill, USA)
7:30 pm - 7:50 pmGaudenz Danuser (University of Texas Southwestern Medical Center, USA)
"Relations Between Cell Shape Control and Survival in Melanoma"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJuliet Daniel (McMaster University, Canada)
"Role of the Catenin-Binding Transcription Factor Kaiso in Tumorigenesis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPanos Anastasiadis (Mayo Clinic, USA)
"Cadherin/RNAi Crosstalk in Epithelial Behavior and Human Cancer"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmChristine Chiasson-MacKenzie (Massachusetts General Hospital / Harvard Medical School, USA)
"Merlin/ERM Proteins Control the Pathway of EGFR Endocytosis by Organizing the Plasma Membrane:Cytoskeleton Interface"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmBethany Perez White (Northwestern University, USA)
"Breaking Down Barriers: Defining the Role of EphA2 in Building Epidermal Tight Junctions in Cancer"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA216892-01 from the National Cancer Institute and the Eunice Kennedy Shriver National Institute of Child Health and Human Development . The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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