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Cell Growth & Proliferation
Gordon Research Conference

Mechanisms of Cell Division with Special Emphasis on Cancer

Dates

July 9-14, 2017

Location

Mount Snow
West Dover, VT Site Information

Organizers

Chair:
Peter Sicinski

Vice Chair:
Jeanette G. Cook

Application Deadline

Applications for this meeting must be submitted by June 11, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

Proliferation of cells represents one of the most fundamental biological processes. The core cell cycle machinery that drives cell proliferation has been conserved from yeast to humans. Proper spatial and temporal control of cell division is essential to allow normal organismal development, and to maintain physiological homeostasis. Abnormal and uncontrolled cell proliferation leads to several pathological states, most notably cancer. Despite decades of research, our understanding of mechanisms governing cell proliferation in normal tissues and in cancer remains very incomplete. The 2017 Gordon Research Conference on Cell Growth and Proliferation will provide a venue to present the most recent discoveries in the field. Leaders in the field will discuss their unpublished work involving cutting-edge approaches and topics, such as studies of normal stem cells and cancer "stem cell-like" cells, analyses of cell populations at a single cell resolution, elucidating the links between cell proliferation and cell metabolism, as well as the roles of non-coding RNAs and epigenetic modifications in regulating cell proliferation. The Conference will focus on abnormal cell proliferation in cancer. Speakers will discuss a range of topics from the use of mouse cancer models to cell cycle-focused targeted therapies for cancer patients. The talks will also cover other aspects of cancer cell proliferation, including aberrant chromosome separation and aneuploidy, proteolysis and cancer, as well as DNA damage and cancer. Because of the emphasis on novelty, the Chairs plan to select approximately half of the talks from submitted abstracts. Hence, the Chairs invite Principal Investigators and trainees from academia and industry to register and submit their most recent work. We also encourage students and post-docs to attend the associated Gordon Research Seminar (GRS) that will immediately precede the research conference. This seminar will offer a great opportunity for networking with other trainees and with Principal Investigators, and to give oral presentations.

Related Meeting

This GRC will be held in conjunction with the "Cell Growth & Proliferation" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Normal and Cancer Stem Cells
Discussion Leader: Peter Sicinski (Dana-Farber Cancer Institute, USA)
7:40 pm - 8:20 pmRobert Weinberg (Whitehead Institute for Biomedical Research, USA)
"Normal and Neoplastic Stem Cells in the Mammary Gland"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmElaine Fuchs (Rockefeller University, USA)
"Balancing Growth and Differentiation in Stem Cells"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMarcos Malumbres (Spanish National Cancer Research Center, Spain)
"Control of Stemness and Tumor Suppression by a Single MicroRNA"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLinking Cell Proliferation and Metabolism
Discussion Leader: Karen Knudsen (Sidney Kimmel Cancer Center, Thomas Jefferson University, USA)
9:00 am - 9:20 amMatthew Vander Heiden (Koch Institute for Integrative Cancer Research at MIT, USA)
"Metabolic Dependencies of Proliferating Cells"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amRobert Abraham (Wyeth Research, USA)
"Bidirectional Interplay Between mTORC1 and Nucleotide Biosynthesis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJan Skotheim (Stanford University, USA)
"How Cell Growth Drives Proliferation"
10:20 am - 10:30 amDiscussion
10:30 am - 11:05 amCoffee Break
11:05 am - 11:20 amShort Talk Selected from Poster Abstracts
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSingle Cell Level Resolution Analyses
Discussion Leader: Carla Bender Kim (Boston Children's Hospital, Harvard Medical School, USA)
7:30 pm - 7:50 pmTobias Meyer (Stanford University, USA)
"Live Cell Analysis of the Mammalian Cell Cycle Entry and Exit Decision"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmSabrina Spencer (University of Colorado Boulder, USA)
"Endogenous Replication Stress in Mother Cells Leads to Quiescence of Daughter Cells"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmShort Talk Selected from Poster Abstracts
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmShort Talk Selected from Poster Abstracts
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNormal and Cancer Cell Cycles
Discussion Leader: Sabrina Spencer (University of Colorado Boulder, USA)
9:00 am - 9:20 amCarla Bender Kim (Boston Children's Hospital, Harvard Medical School, USA)
"Organoid Approaches to Mechanisms of Differentiation and Disease in the Lung"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amTerry Orr-Weaver (Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, USA)
"Developmental Regulation of DNA Replication: Control of Cell Size and Fork Progression"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amHideyuki Saya (Keio University School of Medicine, Japan)
"Role of Actin Dynamics Regulation in Somatic Cell Reprogramming and Cell Fate Determination"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amShiva Malek (Genentech, USA)
"Kinase Dependent and Independent Functions of RAF Kinases"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell Cycle, Proteolysis and Cancer
Discussion Leader: Marcos Malumbres (Spanish National Cancer Research Center, Spain)
7:30 pm - 7:50 pmMichele Pagano (New York University School of Medicine / Howard Hughes Medical Institute, USA)
"SCF Ubiquitin Ligases: Deregulated Proteolysis in Human Cancers"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmBrenda Schulman (St. Jude Children's Research Hospital / Howard Hughes Medical Institute, USA)
"Mechanisms of Cullin-RING Ligases in Cell Cycle Control"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmShort Talk Selected from Poster Abstracts
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmShort Talk Selected from Poster Abstracts
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromosome Separation, Aneuploidy and Cancer
Discussion Leader: Jiri Bartek (Danish Cancer Society, Denmark)
9:00 am - 9:20 amAngelika Amon (Howard Hughes Medical Institute / Massachusetts Institute of Technology, USA)
"Aneuploidy and Cancer - A Complicated Relationship"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amHyunsook Lee (Seoul National University, South Korea)
"Three-Dimensional View of Chromosome Instability After BRCA2 Depletion: Lessons from Mouse and Human Pancreatic Organoids"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJonathon Pines (Institute of Cancer Research, United Kingdom)
"How the Spindle Assembly Checkpoint Arrests Cells in Mitosis"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amDavid Pellman (Dana-Farber Cancer Institute, USA)
"Hiob's Dilemma for the Genome: Why Do Bad Things Happen to Good Chromosomes?"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell Proliferation, DNA Damage and Cancer
Discussion Leader: Jeanette Cook (University of North Carolina at Chapel Hill, USA)
7:30 pm - 7:50 pmMichael Karin (University of California, San Diego, USA)
"Inflammation and DNA Damage Checkpoints Control the Initiation of Liver Carcinogenesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJiri Bartek (Danish Cancer Society, Denmark)
"Replication Stress and DNA Damage Checkpoints in Cancer Development and Treatment"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAnindya Dutta (University of Virginia, USA)
"Novel Insights into DNA Replication Initiation and Double-Strand Break Repair in Cancer Cells"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmShort Talk Selected from Poster Abstracts
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmCancer
Discussion Leader: Mariano Barbacid (Spanish National Cancer Research Centre, Spain)
9:00 am - 9:20 amJacqueline Lees (Koch Institute for Integrative Cancer Research at MIT, USA)
"Targeting Epigenetic Vulnerabilities for Cancer Treatment"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMartine Roussel (St. Jude Children's Research Hospital, USA)
"Role of Epigenetics in Pediatric Medulloblastoma"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amSohail Tavazoie (Rockefeller University, USA)
"Surprising Roles for tRNAs in the Regulation of Cancer Progression"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amGeorge Tsao (University of Hong Kong, Hong Kong SAR China)
"EBV Infection of Nasopharyngeal Epithelial Cells"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell Cycle-Focused Targeted Therapies
Discussion Leader: Jacqueline Lees (Koch Institute for Integrative Cancer Research at MIT, USA)
7:30 pm - 7:50 pmKaren Knudsen (Sidney Kimmel Cancer Center, Thomas Jefferson University, USA)
"Targeting Cell Cycle Dysregulation in Prostate Cancer: Mechanisms and Therapeutic Intervention"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMariano Barbacid (Spanish National Cancer Research Centre, Spain)
"Are Cdks Suitable Therapeutic Targets for K-Ras Driven Tumors?"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJeffrey Engelman (Novartis, USA)
"Targeted Therapies"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmHelen Piwnica-Worms (Washington University in St. Louis, USA)
"Identifying and Targeting Vulnerabilities in Triple Negative Breast Cancer"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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