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Cell Growth and Proliferation
Gordon Research Conference

Mechanisms of Cell Division with Special Emphasis on Cancer

Dates

July 9-14, 2017

Location

Mount Snow
West Dover, VT

Organizers

Chair:
Peter Sicinski

Vice Chair:
Jeanette G. Cook

Meeting Description

Proliferation of cells represents one of the most fundamental biological processes. The core cell cycle machinery that drives cell proliferation has been conserved from yeast to humans. Proper spatial and temporal control of cell division is essential to allow normal organismal development, and to maintain physiological homeostasis. Abnormal and uncontrolled cell proliferation leads to several pathological states, most notably cancer. Despite decades of research, our understanding of mechanisms governing cell proliferation in normal tissues and in cancer remains very incomplete. The 2017 Gordon Research Conference on Cell Growth and Proliferation will provide a venue to present the most recent discoveries in the field. Leaders in the field will discuss their unpublished work involving cutting-edge approaches and topics, such as studies of normal stem cells and cancer "stem cell-like" cells, analyses of cell populations at a single cell resolution, elucidating the links between cell proliferation and cell metabolism, as well as the roles of non-coding RNAs and epigenetic modifications in regulating cell proliferation. The Conference will focus on abnormal cell proliferation in cancer. Speakers will discuss a range of topics from the use of mouse cancer models to cell cycle-focused targeted therapies for cancer patients. The talks will also cover other aspects of cancer cell proliferation, including aberrant chromosome separation and aneuploidy, proteolysis and cancer, as well as DNA damage and cancer. Because of the emphasis on novelty, the Chairs plan to select approximately half of the talks from submitted abstracts. Hence, the Chairs invite Principal Investigators and trainees from academia and industry to register and submit their most recent work. We also encourage students and post-docs to attend the associated Gordon Research Seminar (GRS) that will immediately precede the research conference. This seminar will offer a great opportunity for networking with other trainees and with Principal Investigators, and to give oral presentations.

Related Meeting

This GRC was held in conjunction with the "Cell Growth and Proliferation" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Normal and Cancer Stem Cells
Discussion Leader: Peter Sicinski (Dana-Farber Cancer Institute, USA)
7:40 pm - 8:20 pmRobert Weinberg (Whitehead Institute for Biomedical Research, USA)
"Normal and Neoplastic Stem Cells in the Mammary Gland"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmElaine Fuchs (Rockefeller University, USA)
"Balancing Growth and Differentiation in Stem Cells"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMarcos Malumbres (Spanish National Cancer Research Center (CNIO), Spain)
"Control of Stemness and Tumor Suppression by a Single MicroRNA"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLinking Cell Proliferation and Metabolism
Discussion Leader: Sabrina Spencer (University of Colorado Boulder, USA)
9:00 am - 9:20 amRobert Abraham (Pfizer, USA)
"Bidirectional Interplay Between mTORC1 and Nucleotide Biosynthesis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJan Skotheim (Stanford University, USA)
"How Cell Growth Drives Proliferation"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amMary Lilly (National Institute of Child Health and Human Development, NIH, USA)
"A Conserved Nutrient Stress Pathway Regulates Genome Stability and Retrotransposon Expression During Meiosis"
10:15 am - 10:20 amDiscussion
10:20 am - 10:55 amCoffee Break
10:55 am - 11:15 amMatthew Vander Heiden (Koch Institute for Integrative Cancer Research at MIT, USA)
"Metabolic Dependencies of Proliferating Cells"
11:15 am - 11:25 amDiscussion
11:25 am - 11:40 amPhilipp Kaldis (Institute of Molecular and Cell Biology (IMCB), Singapore)
"Metabolic Rewiring During Liver Regeneration"
11:40 am - 11:45 amDiscussion
11:45 am - 12:00 pmSiwanon Jirawatnotai (Mahidol University, Thailand)
"Cyclin D1 Expression Prevents Cancer Cells from Oxidative Stress-Induced Cellular Senescence"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:20 pmSarah Siegrist (University of Virginia, USA)
"Eyeless Uncouples Neuroblast Proliferation from Dietary Amino Acids in Drosophila"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSingle Cell Level Resolution Analyses
Discussion Leader: Carla Bender Kim (Boston Children's Hospital, Harvard Medical School, USA)
7:30 pm - 7:50 pmTobias Meyer (Stanford University, USA)
"Live Cell Analysis of the Mammalian Cell Cycle Entry and Exit Decision"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmSabrina Spencer (University of Colorado Boulder, USA)
"Endogenous Replication Stress in Mother Cells Leads to Quiescence of Daughter Cells"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmAlexis Barr (Institute of Cancer Research, United Kingdom)
"Endogenous DNA Damage During S-Phase Mediates the Proliferation-Quiescence Decision in the Subsequent G1"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmRan Kafri (The Hospital for Sick Children, Canada)
"Molecular Mechanisms of Size Sensing in Animal Cells"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmYaron Fuchs (Technion - Israel Institute of Technology, Israel)
"Caspase-3 Regulates YAP-Dependent Organ Size and Skin Regeneration"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNormal and Cancer Cell Cycles
Discussion Leader: Karen Knudsen (Sidney Kimmel Cancer Center, Thomas Jefferson University, USA)
9:00 am - 9:20 amCarla Bender Kim (Boston Children's Hospital, Harvard Medical School, USA)
"Organoid Approaches to Mechanisms of Differentiation and Disease in the Lung"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amTerry Orr-Weaver (Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, USA)
"Developmental Regulation of DNA Replication: Control of Cell Size and Fork Progression"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amHideyuki Saya (Keio University School of Medicine, Japan)
"Role of Actin Dynamics Regulation in Somatic Cell Reprogramming and Cell Fate Determination"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amShiva Malek (Genentech, USA)
"Kinase Dependent and Independent Functions of RAF Kinases"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amBruce Futcher (Stony Brook University, USA)
"Global Measurement of How Transcript Abundance Scales with Size in Budding Yeast: Implications for Cell Sizers"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmRobert Duronio (University of North Carolina at Chapel Hill, USA)
"Engineering Metazoan Histone Genes to Determine How Chromatin Influences DNA Replication and Cell Proliferation"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmHelfrid Hochegger (University of Sussex, United Kingdom)
"Disentangling Cyclin A and B Functions in Mitosis Using a Novel Degron-Tagging Approach"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell Cycle, Proteolysis and Cancer
Discussion Leader: Marcos Malumbres (Spanish National Cancer Research Center (CNIO), Spain)
7:30 pm - 7:50 pmMichele Pagano (New York University School of Medicine / Howard Hughes Medical Institute, USA)
"SCF Ubiquitin Ligases: Deregulated Proteolysis in Human Cancers"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmBrenda Schulman (St. Jude Children's Research Hospital / Howard Hughes Medical Institute, USA)
"Mechanisms of Cullin-RING Ligases in Cell Cycle Control"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmAntonio Marzio (Perlmutter Cancer Center, NYU School of Medicine, USA)
"EMIF Forms a Canonical SCF Ubiquitin Ligase Complex that Targets RAD51 for Degradation to Control Homologous Recombination Repair"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmIoannis Sanidas (Massachusetts General Hospital, USA)
"A Integrated Proteomic and Transcriptomic Approach to Resolving the Functional Diversity of the Retinoblastoma Protein (RB)"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmJamy Peng (St. Jude Children's Research Hospital, USA)
"Chromatin Modifier UTX and 53BP1 Control Neurogenic Factors to Balance Human Neural Stem Cell Self-Renewal and Differentiation"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromosome Separation, Aneuploidy and Cancer
Discussion Leader: Jiri Bartek (Danish Cancer Society, Denmark)
9:00 am - 9:20 amAngelika Amon (Howard Hughes Medical Institute / Massachusetts Institute of Technology, USA)
"Aneuploidy and Cancer - A Complicated Relationship"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amHyunsook Lee (Seoul National University, South Korea)
"Three-Dimensional View of Chromosome Instability After BRCA2 Depletion: Lessons from Mouse and Human Pancreatic Organoids"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJonathon Pines (Institute of Cancer Research, United Kingdom)
"How the Spindle Assembly Checkpoint Arrests Cells in Mitosis"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amDavid Pellman (Dana-Farber Cancer Insitute / Harvard Medical School, USA)
"Hiob's Dilemma for the Genome: Why Do Bad Things Happen to Good Chromosomes?"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amPeter Jackson (Stanford University School of Medicine, USA)
"A Combined Protein and Genetic Interaction Map of Kras Effectors and Regulators Reveals Key Susceptibilities in NSCLC"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmAudrey Gasch (University of Wisconsin-Madison, USA)
"Exploiting the Yeast Stress-Activated Signaling Network to Inform on Eukaryotic Growth Control, Stress Biology and Disease Signaling"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmBrian Calvi (Indiana University, USA)
"Repression of a CDK1-Myb Network Remodels Mitotic Cycles into Polyploid Endoreplication Cycles"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell Proliferation, DNA Damage and Cancer
Discussion Leader: Jeanette Cook (University of North Carolina at Chapel Hill, USA)
7:30 pm - 7:50 pmMichael Karin (University of California, San Diego, USA)
"Inflammation and DNA Damage Checkpoints Control the Initiation of Liver Carcinogenesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJiri Bartek (Danish Cancer Society, Denmark)
"Replication Stress and DNA Damage Checkpoints in Cancer Development and Treatment"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAnindya Dutta (University of Virginia, USA)
"Novel Insights into DNA Replication Initiation and Double-Strand Break Repair in Cancer Cells"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmStephen Elledge (Harvard University, USA)
"Mining the Dark Matter of the Cancer Genome: Tissue-Specific Regulators of Cell Proliferation"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmCancer
Discussion Leader: Mariano Barbacid (Spanish National Cancer Research Centre, Spain)
9:00 am - 9:20 amJacqueline Lees (Koch Institute for Integrative Cancer Research at MIT, USA)
"Targeting Epigenetic Vulnerabilities for Cancer Treatment"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMartine Roussel (St. Jude Children's Research Hospital, USA)
"Role of Epigenetics in Pediatric Medulloblastoma"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amSohail Tavazoie (Rockefeller University, USA)
"Surprising Roles for tRNAs in the Regulation of Cancer Progression"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amGeorge Tsao (University of Hong Kong, Hong Kong SAR China)
"EBV Infection of Nasopharyngeal Epithelial Cells"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amHai Jiang (Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, China)
"Shank2, a Novel Evolutionarily Conserved Hippo Pathway Regulator, Is Amplified in Cancers and Promotes Tumorigenesis"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmGrit Pattschull (University of Wuerzburg, Germany)
"The Myb-MuvB Complex and YAP1 Interact to Co-Regulate Cancer-Relevant Genes Involved in Mitosis and Cytokinesis"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelina Chen-Kiang (Weill Cornell Medicine, USA)
"Reprogram Lymphoma Therapy by Targeting CDK4 - Mechanism and Functional Genomics"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell Cycle-Focused Targeted Therapies
Discussion Leader: Jacqueline Lees (Koch Institute for Integrative Cancer Research at MIT, USA)
7:30 pm - 7:50 pmKaren Knudsen (Sidney Kimmel Cancer Center, Thomas Jefferson University, USA)
"Targeting Cell Cycle Dysregulation in Prostate Cancer: Mechanisms and Therapeutic Intervention"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMariano Barbacid (Spanish National Cancer Research Centre, Spain)
"Are Cdks Suitable Therapeutic Targets for K-Ras Driven Tumors?"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJeffrey Engelman (Novartis Institutes for BioMedical Research, USA)
"Targeted Therapies"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmHelen Piwnica-Worms (The University of Texas MD Anderson Cancer Center, USA)
"Identifying and Targeting Vulnerabilities in Triple Negative Breast Cancer"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13 CA220573-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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