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Enzymes, Coenzymes & Metabolic Pathways
Gordon Research Conference

Advances in Enzymology from Determining Enzyme Function to the Interplay of Large Enzyme Systems

Dates

July 24-29, 2016

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chairs:
Adrian T. Keatinge-Clay & Audrey L. Lamb

Vice Chairs:
Graham R. Moran & Andrea Mattevi

Meeting Description

The 2016 Enzymes, Coenzymes, and Metabolic Pathways GRC will highlight the latest advances in enzymology from the fundamentals of determining enzyme function to the interplay of large enzyme systems. The speakers will include established and emerging leaders from academic and industrial institutions. The meeting encourages participation by graduate students and postdoctoral fellows. Selection of poster talks from submitted abstracts and many opportunities for informal discussion will provide interactions will stimulate discussion between scientists from all career stages.

Related Meeting

This GRC was held in conjunction with the "Enzymes, Coenzymes & Metabolic Pathways" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmUnusual Natural Product Enzymology

Discussion Leader: Squire Booker (Pennsylvania State University, USA)
7:40 pm - 8:10 pmBradley Moore (Scripps Institution of Oceanography, USA)
"Marine Natural Products as an Inspiration for New Biosynthetic Enzymology"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:45 pmGregory Challis (University of Warwick, United Kingdom)
"Elucidating and Exploiting Biosynthetic C-H Functionalization"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmDavid Christianson (University of Pennsylvania, USA)
"Structural Biology and Chemistry of Histone Deacetylases in Human Disease and Drug Discovery"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLarge Complexes

Discussion Leader: Martin St. Maurice (Marquette University, USA)
9:00 am - 9:30 amTimm Maier (University of Basel, Switzerland)
"Structure and Evolution of Fatty Acid and Reducing Polyketide Synthases"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amShelley Minteer (University of Utah, USA)
"Substrate Channeling in Natural and Artificial Krebs Cycle Metabolons"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amGroup Photo / Coffee Break
10:50 am - 11:05 amSongon An (University of Maryland, Baltimore County, USA)
"A Regulatory Enzyme Complex for Glucose Metabolism in Living Cells: 'The Glucosome'"
11:05 am - 11:10 amDiscussion
11:10 am - 11:40 amLiang Tong (Columbia University, USA)
"Structure and Function of Large Metabolic Enzymes"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmLorenzo Finci (Tsinghua University, China)
"Structure and Function of the Spliceosome"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour

The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.

Organizer: Holly Ellis (Auburn University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmUnusual Coenzymes

Discussion Leader: Tadhg Begley (Texas A&M University, USA)
7:30 pm - 8:00 pmPaul Fitzpatrick (University of Texas Health Science Center, USA)
"Regulation of the Pterin-Dependent Aromatic Amino Acid Hydrolases"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmRobert White (Virginia Tech, USA)
"Digging for Metabolic Fossils in the Methanogenic Archaea"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmHung-Wen Liu (University of Texas at Austin, USA)
"Characterization of a Cobalamin-Dependent Radical SAM Enzyme"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEnzyme Inhibition

Discussion Leader: Lynn Abell (Bristol-Myers Squibb, USA)
9:00 am - 9:30 amDennis Murphy (Merck Research Laboratories, USA)
"Determination of In Vivo Enzyme Occupancy Utilizing Inhibitor Dissociation Kinetics"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amBenjamin Cravatt (Scripps Research Institute, USA)
"Enzyme and Inhibitor Discovery Using Chemical Proteomics"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amAlan Rendina (GlaxoSmithKline, USA)
"A Fatty Acid Synthase KRyptonite for Structure, Mechanism and Cancer"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amBrian Miller (Florida State University, USA)
"Allokairic Regulation of Enzyme Function"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmDali Liu (Loyola University Chicago, USA)
"Molecular Recognition of Pyruvate as an Allosteric Activator for ADP-Glucose Pyrophosphorylase from Agrobacterium tumefaciens"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmY. George Zheng (University of Georgia, USA)
"Mechanistic Insights of Protein Arginine Methyltransferases"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMetalloenzymes

Discussion Leader: Catherine Goodman (Journal of Biological Chemistry, USA)
7:30 pm - 8:00 pmPinghua Liu (Boston University, USA)
"Endoperoxide Formation by an a-Ketoglutarate-Dependent Mononuclear Non-Haem Iron Enzyme"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmHideaki Ogata (Max Planck Institute for Chemical Energy Conversion, Germany)
"Catalytic Reaction Mechanism of [NiFe] Hydrogenase"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAmie Boal (Pennsylvania State University, USA)
"Metallocofactor Assembly in a Novel Manganese-Dependent Class I Ribonucleotide Reductase"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDetermining Enzyme Function

Discussion Leader: Elham Behshad (Incyte Corp., USA)
9:00 am - 9:30 amGraham Moran (University of Wisconsin-Milwaukee, USA)
"Renalase, a Decade of Phantoms"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amReuben Peters (Iowa State University, USA)
"Mechanistic Insights from Systematic Investigation of (Di)Terpenoid Biosynthesis"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:05 amRebecca Butcher (University of Florida, USA)
"Discovery and Biosynthesis of Hybrid Polyketide-Nonribosomal Peptides in Nematodes"
11:05 am - 11:10 amDiscussion
11:10 am - 11:40 amValerie De Crecy-Lagard (University of Florida, USA)
"Discovering Novel and Missing Enzymes by Comparative Genomics"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmElizabeth Sattely (Stanford University, USA)
"Plant Pathway Discovery for Plant and Human Health"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting

Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmBiocatalysis

Discussion Leader: Thomas Meek (Texas A&M University, USA)
7:30 pm - 8:00 pmJon Stewart (University of Florida, USA)
"Understanding Alkene Reductases and Learning How to Make Them Better Biocatalysts"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmRobert Dicosimo (DuPont Industrial Biosciences, USA)
"Enzymatic Production of Soluble Carbohydrate Fiber for Food Ingredient Applications"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmKevin Walker (Michigan State University, USA)
"Biocatalysis and Repurposing of Enzymes on Pathways to Bioactive Natural Products"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAssembly Lines

Discussion Leader: Barbara Gerratana (National Institute of General Medical Sciences, NIH, USA)
9:00 am - 9:30 amSheryl Tsai (University of California, Irvine, USA)
"Structural Enzymology and Protein Dynamics of Fatty Acid, Polyketide, and Nonribosomal Peptide Megasynthases"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amSteven Bruner (University of Florida, USA)
"Structure and Mechanism of the Transporter for the E. coli Genotoxin, Colibactin"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amCharles Melancon (University of New Mexico, USA)
"A Bioinformatic Roadmap for Discovering and Engineering Type II Polyketide Biosynthetic Pathways and Enzymes"
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amJorn Piel (Institute of Microbiology, ETH Zurich, Switzerland)
"Investigating and Utilizing trans-AT Polyketide Synthase Assembly Lines"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmAndrew Gulick (Hauptman-Woodward Medical Research Institute, University at Buffalo, USA)
"Conformational Changes that Drive the Dynamic Structural Cycle of the Nonribosomal Peptide Synthetases"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmMartin Schmeing (McGill University, Canada)
"Visualizing the First Steps of a Megaenzyme Making an Antibiotic"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmKeynote Session: Learning from Naturally Gifted Enzymes

Discussion Leader: Karen Allen (Boston University, USA)
5:30 pm - 6:20 pmDebra Dunaway-Mariano (University of New Mexico, USA)
"Catalytic Diversity Among Phosphotransferases: Vignettes of Mechanism and Molecular Evolution"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 7:20 pmDale Poulter (University of Utah, USA)
"Biosynthesis of Squalene. Five Enzymes, Two Coenzymes, and a Metabolic Pathway"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible in part by 1R13AI126824-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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