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Enzymes, Coenzymes & Metabolic Pathways
Gordon Research Conference

Emerging Methods and Concepts to Advance Enzyme Chemistry in Biology

Dates

July 16-21, 2017

Location

Waterville Valley
Waterville Valley, NH Site Information

Organizers

Chairs:
Graham R. Moran & Andrea Mattevi

Vice Chairs:
Holly R. Ellis & Kay Ahn

Application Deadline

Applications for this meeting must be submitted by June 18, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

It is 104 years since Michealis and Menten described that the rate of an enzyme reaction is proportional the the enzyme-substrate complex. The Enzymes Coenzymes and Metabolic Pathways Gordon Research Conference has chronicled advances in the study of enzymes and related fields for 70 of those years. In this 70th anniversary year the theme of the ECMP GRC will be part retrospective and part state of the art. The purpose of which is to illustrate the evolution of ideas in this chemically dense area of biochemistry and to show the potential that new tools and methods offer this field of inquiry.

Related Meeting

This GRC will be held in conjunction with the "Enzymes, Coenzymes & Metabolic Pathways" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNovel Cofactors and Chemistry
Discussion Leader: Eugene Mueller (University of Louisville, USA)
7:40 pm - 8:10 pmNeil Marsh (University of Michigan, USA)
"Prenyl-Flavin: A New Cofactor for Aromatic Decarboxylations"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:45 pmRobert Hausinger (Michigan State University, USA)
"Lactate Racemase and Its Novel Ni-Pincer Cofactor"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmKatherine Ryan (University of British Columbia, Canada)
"Discovery of a PLP-Dependent Oxidase in the Pathway to the Antibiotic Indolmycin"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAdvances in Structural Methodology
Discussion Leader: Jennifer Dubois (Montana State University, USA)
9:00 am - 9:30 amWerner Kühlbrandt (Max Planck Institute of Biophysics, Germany)
"High-Resolution Protein Structures by CryoEM - Is Crystallography Obsolete"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amSriram Subramaniam (National Cancer Institute, NIH, USA)
"Atomic Resolution Cryo-EM of Metabolic Enzymes"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amGroup Photo / Coffee Break
10:50 am - 11:20 amAbbas Ourmazd (University of Wisconsin-Milwaukee, USA)
"Structure and Dynamics from Single-Particle Snapshots"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmCarrie Wilmot (University of Minnesota, USA)
"MauG Catalysis: A Tale of Ferryl Iron, Radicals and Long Distance Hopping"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNucleic Acid Enzymology
Discussion Leader: Jeffrey Smiley (Center for Scientific Review, NIH, USA)
7:30 pm - 8:00 pmXiaodong Cheng (Emory University, USA)
"On the Mechanism of Generation, Recognition, and Erasure of DNA Modifications"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmChristopher Schofield (University of Oxford, United Kingdom)
"New Metallo-Enzymes Regulating Protein Biosynthesis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAndrea Musacchio (Max Planck Institute of Molecular Physics, Germany)
"The Role of Catalysis in Mitotic Checkpoint Control over the Cell Cycle"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEnzyme Discovery, Structure and Mechanism
Discussion Leader: Nicole Neuman (Trends in Biochemical Sciences, Cell Press, USA)
9:00 am - 9:30 amPatrick Frantom (University of Alabama, USA)
"Investigations of Regulatory and Functional Diversity in an Enzyme Superfamily"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amMartin St. Maurice (Marquette University, USA)
"Regulation of Carrier Domain Movements in Pyruvate Carboxylase"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amPablo Sobrado (Virginia Tech, USA)
"Noncanonical Reactions Catalyzed by Atypical Flavoenzymes"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmAudrey Lamb (University of Kansas, USA)
"Unravelling the MSTery"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPutting Enzymes to Work
Discussion Leader: Michael Knapp (University of Massachusetts Amherst, USA)
7:30 pm - 8:00 pmStefan Gross (Agios Pharmaceuticals, USA)
"Treatment of Inborn Errors of Metabolism by Small Molecule Allosteric Activators"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmF. Peter Guengerich (Vanderbilt University School of Medicine, USA)
"Old and New Twists on Cytochrome P450: Desaturation, C-C Bond Cleavage, and Reversible Oxidation of the Thiolate Heme Ligand"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmNigel Scrutton (University of Manchester, United Kingdom)
"H Transfer and Biocatalysis with Natural and Artificial Coenzymes"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChemical Biology
Discussion Leader: Melanie Hall (University of Graz, Austria)
9:00 am - 9:30 amDaniel Nomura (University of California, Berkeley, USA)
"Using Chemoproteomic Platforms to Map Druggable Hotspots in Human Disease"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amAlbert Bowers (UNC Eshelman School of Pharmacy, USA)
"Chemoenzymatic Platforms for the Discovery of New Peptide Therapeutics"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amAlanna Schepartz (Yale University, USA)
"Seeing into Cells"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmBiocatalysis
Discussion Leader: Aimin Liu (University of Texas at San Antonio, USA)
7:30 pm - 8:00 pmKurt Faber (University of Graz, Austria)
"Regio-Complementary Carboxylation of Aromatics: Diverging Reactivities Through Different Enzyme Mechanisms"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmFrances Arnold (California Institute of Technology, USA)
"Directed Evolution of Abiological Catalysts Based on Heme Proteins"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmJeffrey Moore (Merck & Co., USA)
"Development of New and Improved Enzymes for Industrial Biocatalysis"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmComputational Enzymology
Discussion Leader: Erika Taylor (Wesleyan University, USA)
9:00 am - 9:30 amSteven Schwartz (University of Arizona, USA)
"Protein Dynamics and Catalysis: Evolution and Artificial Design"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amTomasz Borowski (Polish Academy of Sciences, Poland)
"Mechanisms of Mononuclear Non-Heme Enzymes Studied with Computational Methods"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amDorothee Kern (Howard Hughes Medical Institute / Brandeis University, USA)
"Recreating the Evolution of Enzyme Catalysis Over 3.5 Billion Years"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmThe Evolving State of the Art
Discussion Leader: Thomas Meek (Texas A&M University, USA)
5:30 pm - 6:20 pmWilfred van der Donk (Howard Hughes Medical Institute / University of Illinois at Urbana-Champaign, USA)
"How Can One Enzyme Act on 30 Different Substrates?"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 7:20 pmKenneth Johnson (University of Texas at Austin, USA)
"A Century of Enzyme Kinetic Analysis"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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