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Hemostasis
Gordon Research Conference

Research at the Interface of Hemostasis and Human Disease

Dates

July 24-29, 2016

Location

Stoweflake Conference Center
Stowe, VT

Organizers

Chairs:
James H. Morrissey & Jorge A. DiPaola

Vice Chair:
Alisa S. Wolberg

Meeting Description

First organized by hemostasis pioneers Earl W. Davie and Oscar Ratnoff in 1973, the Hemostasis Gordon Research Conference (GRC) is considered the premiere small-format scientific meeting on the topics of blood coagulation, platelet biology, anticoagulant pathways and associated diseases. The Hemostasis GRC brings together scientists interested in the biology, biochemistry and genetics of platelets and coagulation proteins - including the myriad roles these proteins play beyond hemostasis; physicians involved in the treatment of bleeding and thrombotic diseases; and investigators from small and large pharmaceutical/biotechnology companies developing new therapeutics and diagnostics for disorders of the hemostatic system. The 2016 Hemostasis GRC will be held July 24-29 at Stoweflake Mountain Resort and Conference Center in Stowe, Vermont - only 36 miles from Burlington International Airport. The conference site provides a comfortable and inviting location for all participants surrounded by the Green Mountains, including a Pinnacle Award Conference Center and over 40,000 square feet of highly functional space for indoor and outdoor activities. Numerous recreational activities are available to participants including horseback riding, biking, hiking, golf, tennis, boating, and swimming.

A primary goal of the conference is for nearly every attendee to participate actively either as a speaker, discussion leader, or poster presenter. Held before dinner on four days of the conference, the poster sessions are always well attended and provide a dedicated forum for interaction among junior and senior investigators in the field. Afternoons are open for informal discussion among attendees and leisure activities that enhance interactions, intellectual exchange, and foster new collaborations—a traditional and unique component of the Hemostasis GRC. All applicants who are not invited speakers or discussion leaders are encouraged to submit an abstract for presentation at one of the four scheduled poster sessions and consideration for an oral presentation at the Late-Breaking Topics session.

Related Meeting

This GRC was held in conjunction with the "Hemostasis" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmClotting Factors and Platelets – Beyond Hemostasis
Discussion Leader: Robert Montgomery (Blood Research Institute, Medical College of Wisconsin, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 7:55 pmIntroduction by Discussion Leader
7:55 pm - 8:20 pmShaun Jackson (Heart Research Institute, Australia)
"Role of Procoagulant Platelets in Ischemia Reperfusion"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 8:50 pmEric Mullins (Cincinnati Children's Research Foundation, USA)
"Role of Plasminogen in Neurodegenerative Diseases"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmPeter Newman (Blood Research Institute, BloodCenter of Wisconsin, USA)
"CRISPR-Mediated Generation of Antigenically-Distinct Platelet Progenitors from Human iPS Cells"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmFactor VIII and Von Willebrand Factor: Redefining the Relationship
Discussion Leader: James O'Donnell (Trinity College, Dublin, Ireland)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amAndrew Yee (University of Michigan, USA)
"Mapping the Interaction Between FVIII and VWF"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amPeter Lenting (INSERM, France)
"In Vivo Models to Study the VWF/FVIII Axis"
10:10 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amKarl Desch (University of Michigan, USA)
"Genomic Approaches to VWF and FVIII Variability"
11:20 am - 11:35 amDiscussion
11:35 am - 12:00 pmPaul Monahan (Baxalta, USA)
"Curing Hemophilia B"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Alisa Wolberg (University of North Carolina at Chapel Hill, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMegakaryocytes, Platelets and Cancer
Discussion Leader: Xiaoping Du (University of Illinois at Chicago, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmTatiana Byzova (Cleveland Clinic, USA)
"Tumor Progression, Platelets and Angiogenesis"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmHerve Falet (Brigham and Women's Hospital, USA)
"Endocytosis and Mpl/JAK2 Signaling in Megakaryocytes and Myelofibrosis"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmMyriam Labelle (St. Jude Children's Research Hospital, USA)
"Platelets and the Early Metastatic Niche"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInflammation and Hemostasis
Discussion Leader: Jose Lopez (Bloodworks Northwest Research Institute, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amAlireza Rezaie (St. Louis University School of Medicine, USA)
"Crosstalk of Proteases and Inflammation"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amX. Long Zheng (University of Alabama at Birmingham, USA)
"Novel Therapeutics for Autoimmune TTP"
10:10 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:15 amKeith McCrae (Cleveland Clinic, USA)
"Hemostatic and Non-Hemostatic Functions of High Molecular Weight Kininogen"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amEdward Conway (Center for Blood Research, University of British Columbia, Canada)
"Complement, Inflammation and the Clotting Cascade"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmMatthew Rondina (University of Utah, USA)
"Platelet Reprogramming in Sepsis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPlatelets and Clotting Factors in Normal Hemostasis
Discussion Leader: Peter Newman (Blood Research Institute, BloodCenter of Wisconsin, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmWolfgang Bergmeier (University of North Carolina at Chapel Hill, USA)
"Putting the Brakes on Platelets"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmRodney Camire (Children's Hospital of Philadelphia / University of Pennsylvania, USA)
"Rediscovering Factor V"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmJordan Shavit (University of Michigan, USA)
"Use of Zebrafish as a Model for Hemostasis"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMegakaryocytes, Platelets and the Bone Marrow Niche
Discussion Leader: Steven McKenzie (Thomas Jefferson University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amPaul Bray (Thomas Jefferson University, USA)
"Plateletomics: Exploring Platelet Biology via Multi-Omic Data Integration"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amKarin Hoffmeister (Brigham and Women's Hospital / Harvard Medical School, USA)
"The Molecular Mechanisms of Platelet Clearance"
10:10 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:15 amBenjamin Kile (Walter and Eliza Hall Institute for Medical Research, Australia)
"The Role of Apoptosis in the Regulation of Platelet Survival and Function"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amJoe Italiano (Brigham and Women's Hospital / Harvard University, USA)
"Triggering Platelet Production"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmAlessandra Balduini (Tufts University, USA)
"Scaffolds for Megakaryocyte Development"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmLate-Breaking Topics
Speakers for Late-Breaking Topics were selected from submitted abstracts.
Discussion Leader: Alisa Wolberg (University of North Carolina at Chapel Hill, USA)
7:30 pm - 7:40 pmJoseph Aslan (Oregon Health and Science University, USA)
"Deciphering Roles for Reversible Protein Lysine Acetylation in the Regulation of Platelet Function"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSilvia Giannini (Brigham and Women's Hospital, USA)
"JAK2 Regulates β4galt1-Dependent Glycan Synthesis on β1-Integrin to Promote Thrombopoiesis"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmMarco Heestermans (Leiden University Medical Center, The Netherlands)
"Silencing of Anticoagulant Protein C Evokes Low Incident but Spontaneous Atherothrombosis in Apolipoprotein E Deficient Mice"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmLalitha Nayak (Case Western Reserve University, USA)
"Myeloid Kruppel-Like Factor 2 (KLF2) Alters Tissue Factor Activity and Is a Critical Determinant of Arterial Thrombosis"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmDmitry Nechipurenko (Lomonosov Moscow State University, Russia)
"Outward Migration of Procoagulant Platelets to Thrombus Surface Is Driven by Thrombus Contraction"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmJamie O'Sullivan (Trinity College, Dublin, Ireland)
"N-Linked Glycans at N1515 and N1574 Within the A2 Domain of VWF Play a Critical Role in Modulating Macrophage-Mediated Clearance"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmClaudia Tersteeg (KU Leuven Kulak, Belgium)
"Endogenous Plasmin Activity in Acute Thrombotic Thrombocytopenic Purpura"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSidney Whiteheart (University of Kentucky, USA)
"Platelet Endocytosis in Immune Responses to Viral Infection"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHemostasis and the Interface with the Vessel Wall
Discussion Leader: Skip Brass (University of Pennsylvania, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amKeith Neeves (Colorado School of Mines, USA)
"Magnetically Propelled Microwheels for Rapid Fibrinolysis"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amRenhao Li (Emory University, USA)
"Platelet Mechanosensation: To Pull the Trigger, Not Cluster"
10:10 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:15 amSatya Kunapuli (Temple University, USA)
"Platelet Signaling and the Vessel Wall"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amWilbur Lam (Emory University / Georgia Institute of Technology, USA)
"Spatial and Mechanical Cues of the Platelet Microenvironment and Their Roles in Clot Format"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmMatthew Auton (Mayo Clinic, USA)
"Conformational Activation of VWF"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: New Therapies and Targets
Discussion Leader: Kenneth Mann (Haematologic Technologies, Inc., USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:20 pmDenisa Wagner (Harvard Medical School, USA)
"NETs in Thrombosis and Inflammation"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmJ. Evan Sadler (Washington University in St. Louis, USA)
"Von Willebrand Factor/ADAMTS13 and Their Role in Health and Disease"
9:15 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL132417-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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