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Ion Channels
Gordon Research Conference

Molecular Basis for Electrical Signaling in the Nervous System and Beyond

Dates

July 10-15, 2016

Location

Mount Holyoke College
South Hadley, MA

Organizers

Chair:
Emily R. Liman

Vice Chair:
Chris A. Ahern

Meeting Description

The 2016 Gordon Research Conference on Ion Channels will continue a long tradition of bringing together leading researchers to share unpublished, cutting-edge research focused on the proteins responsible for electrical signaling in the nervous systems and other tissues of vertebrate and invertebrate organisms. The meeting will address the fundamental basis of ion channel structure and function, including mechanisms of regulation and modulation and the contribution of ion channels to cellular physiology, in health and disease. We have designed the 2016 meeting agenda to cover a broad range of ion channels, including thermo- and mechano-sensitive ion channels, and to showcase new genetic approaches to ion channel research, which allow one to begin to identify the full complexity of channels within a cell type. Invited speakers and discussion leaders have been chosen to generate a program that both covers the breadth of ion channel research, and presents the most cutting-edge research. In addition, all participants are asked to submit an abstract for presentation in the poster session, from which approximately ten short talks will be chosen. We strongly encourage graduate students and post-doctoral fellows to apply to both the 2016 Ion channels GRC and to the GRS held immediately before the meeting.

Related Meeting

This GRC was held in conjunction with the "Ion Channels" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: New Directions in Ion Channel Research
Discussion Leader: David Clapham (Harvard Medical School, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:25 pmRichard Tsien (New York University School of Medicine, USA)
"Novel Modes of Information Transfer to Drive Neuronal Plasticity"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:10 pmDavid Julius (University of California, San Francisco, USA)
"Structural Insights into Pain Sensation"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmThermosensing Through Ion Channels
Discussion Leader: Magdalene Moran (Hydra Biosciences, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amJie Zheng (University of California, Davis, USA)
"TRPV1 Activation by Vanilloids"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amRamon Latorre (University of Valparaíso, Chile)
"Allosterism and Structure in Thermally-Activated Transient Receptor Potential Channels"
10:05 am - 10:15 amDiscussion
10:15 am - 10:40 amSharona Gordon (University of Washington, USA)
"Measuring Confomational Dynamics in TRPV1 Using ncAA and tmFRET"
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:40 amBaron Chanda (University of Wisconsin-Madison, USA)
"Hidden in Plain Sight: A Plausible Mechanism of Temperature-Sensing"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmCandice Paulsen (University of California, San Francisco, USA)
"Structure of the TRPA1 Ion Channel Suggests Regulatory Mechanisms"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Miriam Goodman (Stanford University, USA) and Sharona Gordon (University of Washington, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStructure of Ion Channels
Discussion Leader: Brad Rothberg (Temple University School of Medicine, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmDaniel Minor (University of California, San Francisco, USA)
"How Do Channels Respond to Temperature?"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmDonald Gill (Pennsylvania State University, USA)
"Understanding the STIM-Orai Coupling Interface"
8:30 pm - 8:35 pmDiscussion
8:35 pm - 9:00 pmRachelle Gaudet (Harvard University, USA)
"Substrate Selectivity in Nramp-Family Transition Metal Transporters"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmRyan Hibbs (University of Texas Southwestern Medical Center, USA)
"Nicotinic Acetylcholine Receptors"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanosensory Ion Channels
Discussion Leader: Miriam Goodman (Stanford University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amBailong Xiao (School of Pharmaceutical Sciences, Tsinghua University, China)
"Structural and Functional Characterizations of the Mechanosensitive Piezo1 Channel"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amJorg Grandl (Duke University, USA)
"Mechanism of Activation and Modulation of Piezo Ion Channels"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amRuhma Syeda (The Scripps Research Institute, USA)
"Piezo1 Channels Are Inherently Mechanosensitive"
10:30 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:25 amSlav Bagriantsev (Yale University, USA)
"Neuronal Mechanoreception in Tactile Specialist Ducks"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmCraig Montell (University of California, Santa Barbara, USA)
"The Molecular and Cellular Basis of Gustatory Detection in Drosophila"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmFrancesco Tombola (University of California, Irvine, USA)
"Mechanosensitivity of the Hv1 Channel"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmModulation of Ion Channels
Discussion Leader: Ann Rittenhouse (University of Massachusetts Medical School, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmTibor Rohacs (Rutgers New Jersey Medical School, USA)
"Regulation of Somatosensory Ion Channels by Phosphoinositides"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmBruce Bean (Harvard Medical School, USA)
"Endocannabinoid Modulation of Dopamine Neuron Excitability"
8:30 pm - 8:35 pmDiscussion
8:35 pm - 9:00 pmDiomedes Logothetis (Virginia Commonwealth University, USA)
"Phosphoinositide and G Protein Regulation of Inwardly Rectifying Potassium Channels"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmBonnie Wallace (Birkbeck, University of London, United Kingdom)
"The Complete Crystal Structure of an Activated Open Sodium Channel"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIon Channels in Concert
Discussion Leader: Bertil Hille (University of Washington, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amMark Nelson (University of Vermont, USA)
"Ion Channel Networks in the Control of Cerebral Blood Flow"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amDiane Papazian (University of California, Los Angeles, USA)
"Ion Channel Gating and Infant-Onset Neurological Diseases"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amPolina Lishko (University of California, Berkeley, USA)
"Steroids, Endocannabinoids and Ion Channels"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amAndrea Meredith (University of Maryland School of Medicine, USA)
"Molecular Mechanisms of Circadian Variation in BK Current Properties"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmMark Shapiro (University of Texas Health Science Center at San Antonio, USA)
"Clustering of Diverse Channels and Receptors in Sensory Neurons Revealed at the Single-Molecule Level by Super-Resolution Microscopy"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAssembly and Trafficking of Ion Channels
Discussion Leader: Carol Deutsch (University of Pennsylvania, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmGail Robertson (University of Wisconsin-Madison, USA)
"Co-Translational Association of mRNA Encoding Heteromeric Ion Channels"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmPaul Slesinger (Icahn School of Medicine at Mount Sinai, USA)
"Psychostimulants Put GIRK Channels on the Move"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:00 pmThomas Baukrowitz (University of Kiel, Germany)
"A Non-Canonical Voltage Sensor Controls Gating in K2P K+ Channels"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmEunyong Park (Rockefeller University, USA)
"Structure and Mechanism of CLC Chloride Channels"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmEngineering Ion Channels
Discussion Leader: Chris Ahern (University of Iowa, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amEhud Isacoff (University of California, Berkeley, USA)
"Gating mGluRs"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amWilliam Kobertz (University of Massachusetts Medical School, USA)
"Fluorescent Visualization of Cellular Efflux"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amHongkang Zhang (Harvard University, USA)
"Optical Electrophysiology for Probing Function and Pharmacology of Voltage-Gated Ion Channels"
10:30 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:25 amRichard Kramer (University of California, Berkeley, USA)
"Chemical Photosensitization of Voltage-Gated Ion Channels as a Strategy for Restoring Vision to the Blind"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmAndrew Plested (Leibniz Institute for Molecular Pharmacology, Germany)
"Glutamate Receptors: Lights, Camera, Action"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmJian Payandeh (Genentech, Inc., USA)
"How to Trap a Voltage-Sensor: Insights from Engineering Nav1.7-Selective Inhibition"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew Ion Channels / New Functions for Ion Channels
Discussion Leader: Andrea Brueggemann (Nanion Technologies, Germany)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:50 pmWillem Laursen (Yale University, USA)
"Diminished Heat Sensitivity of TRPV1 Supports Heat Tolerance in Ground Squirrels and Camels"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:10 pmIan Ramsey (Virginia Commonwealth University, USA)
"Hv1 Proton Channel Gating"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmKevin Foskett (Perelman School of Medicine, University of Pennsylvania, USA)
"CALHM Ion Channels in Taste Perception"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmChristopher Miller (Brandeis University, USA)
"A Weird Ion Channel for a Weird Ion"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institutes of Health under award number 1R13NS096763. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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