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Lysosomes and Endocytosis
Gordon Research Conference

Molecular Mechanisms and Functions of Endosomal and Lysosomal Pathways

Dates

June 12-17, 2016

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Roberto Weigert

Vice Chair:
Lois S. Weisman

Meeting Description

The Gordon Research Conference on Lysosomes and Endocytosis covers recent advances in understanding the function and molecular regulation of the endocytic pathways, lysosomes, and related subcellular organelles. Lysosomal and endocytic pathways have central roles in the physiology of all eukaryotic cells. These pathways provide major conduits for communication with the extracellular environment, as platforms for cellular signaling events, nutrient uptake, and cytokinesis, and as the first cellular line of defense to prevent damage from infectious or toxic agents. Specialized cell types utilize components of the endocytic and lysosomal systems for diverse physiological processes such as glucose and lipid metabolism, immune recognition and effector function, inflammation and cytotoxicity, blood coagulation and hemostasis, and pigmentation. Generalized defects in endosomal or lysosomal function are linked to cancer, developmental, metabolic and immune disorders, and neurodegeneration.

Topics of focus for the 2016 meeting include molecular mechanisms and cell biology of endocytic and degradative pathways, as well as their role in human health and disease. Sessions will cover molecular features of endocytic membrane traffic such membrane remodeling at the plasma membrane, membrane-cytoskeleton interactions and cell physiology including endosomal and lysosomal membrane traffic, autophagy and formation and function of specialized lysosome-related organelles. Other sessions will focus on the roles of endocytic pathways in cancer progression, diabetes and metabolism, neurological disorders, and host-pathogen interactions. The conference will feature a session on 'New Directions' in which novel technical and conceptual developments in the field will be discussed. The meeting will be divided into nine half-day sessions, comprising a mixture of invited speakers and those selected from abstracts. Attendance by under-represented minorities, students, postdoctoral fellows, junior faculty, and faculty from primarily undergraduate institutions is encouraged.

Prior to and in association with the Gordon Research Conference, there will be a Gordon Research Seminar on Lysosomes and Endocytosis, in which students and post-doctoral researchers can present their work to each other and attend instructional seminars prior to the arrival of senior investigators. Interested trainees are encouraged to view the web site and consider attending.

Related Meeting

This GRC was held in conjunction with the "Lysosomes and Endocytosis" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEndocytic Machinery at the Plasma Membrane
Discussion Leaders: Sandra Schmid (University of Texas Southwestern Medical Center, USA) and Mark Von Zastrow (University of California, San Francisco, USA)
7:40 pm - 8:00 pmVolker Haucke (Leibniz-Institut für Molekulare Pharmakologie, Germany)
"Phosphoinositide Conversion Within the Endolysosomal System"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmLudger Johannes (Institut Curie, France)
"Using Glycosphingolipids to Build Endocytic Pits in Clathrin-Independent Endocytosis"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmMargaret Robinson (University of Cambridge, United Kingdom)
"Coated Vesicle Adaptors"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSara Sigismund (IFOM, The FIRC Institute for Molecular Oncology Foundation, Italy)
"ER-PM Contact Sites Control EGFR Endocytosis"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndosomal Sorting and Recycling
Discussion Leaders: Elizabeth Conibear (University of British Columbia, Canada) and Scott Emr (Cornell University, USA)
9:00 am - 9:20 amPeter Cullen (University of Bristol, United Kingdom)
"Molecular Mechanisms of Endosomal Cargo Sorting and Export"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJulie Donaldson (National Heart, Lung, and Blood Institute, NIH, USA)
"Sorting of Endosomal Cargo: Role of Cytoskeleton and Motors"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amManojkumar Puthenveedu (Carnegie Mellon University, USA)
"GPCR Localization and Signaling in Endosomal Recycling Microdomains"
10:15 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 11:05 amErik Jorgensen (Howard Hughes Medical Institute / University of Utah, USA)
"Ultrafast Endocytosis of Synaptic Vesicles"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amJulie Brill (The Hospital for Sick Children, Canada)
"Regulation of Endosomal Sorting and Recycling by PI4P"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmAitor Hierro (CIC bioGUNE, Spain)
"Cargo-Specific Sorting from Endosomes"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmZuzana Kadlecova (University of Texas Southwestern Medical Center, USA)
"Hierarchical Allosteric Regulation of AP2 Activity Controls Clathrin-Mediated Endocytosis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmExploiting the Endocytic Machinery During Host-Pathogen Interactions
Discussion Leaders: Sergio Grinstein (Hospital for Sick Children, Canada) and Fabienne Paumet (Thomas Jefferson University, USA)
7:30 pm - 7:50 pmNihal Altan-Bonnet (National Institutes of Health, USA)
"Enteroviruses Transmission Through PS Vesicles"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:15 pmMark Marsh (University College London, United Kingdom)
"IFITM Proteins - Endosomal Broad-Spectrum Inhibitors of Virus Entry"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmNels Elde (University of Utah, USA)
"Adaptations Blocking Viral Exploitation of the ESCRT Pathway"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmJulie Magarian Blander (Icahn School of Medicine at Mount Sinai, USA)
"Regulation of Vesicular Traffic for Meeting the Demands of Cross-Presentation"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmShaeri Mukherjee (University of California, San Francisco, USA)
"Bacterial Manipulation of the Host Unfolded Protein Response"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmDysregulation of Endosomal and Lysosomal Trafficking During Cancer and Other Pathologies
Discussion Leaders: Alexander Sorkin (University of Pittsburgh School of Medicine, USA) and JoAnn Trejo (University of California, San Diego, USA)
9:00 am - 9:20 amPhilippe Chavrier (Institut Curie, France)
"Exocytosis from Late Endosomes Drives MT1-MMP Digest-on-Demand Response During Breast Cancer Invasion"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amVictor Faundez (Emory University, USA)
"Genealogy Based Inference of Cellular Mechanisms in Complex Disorders"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amDoug Brooks (University of South Australia, Australia)
"Altered Endosome Cell Biology in Prostate Cancer"
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amRosalind Segal (Harvard Medical School / Dana-Farber Cancer Institute, USA)
"Endocytosis and Signaling During Neurodegeneration"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amAlissa Weaver (Vanderbilt University School of Medicine, USA)
"Regulation of Multivesicular Body Trafficking and Secretion in Cancer"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmChiara Zurzolo (Pasteur Institute, France)
"Lysosomes Mediate the Transfer of Pathogenic Alpha Synuclein Fibrils Between Neurons in Tunneling Nanotubes (TNTs)"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmFlorian Froehlich (University of Osnabrück, Germany)
"Endosomal Trafficking in Sphingolipid Homeostasis and Its Implications in Neurodegenerative Disorders"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMetabolism and Related Diseases
Discussion Leaders: Frances Brodsky (University of California, San Francisco, USA / University College London, United Kingdom) and Mara Duncan (University of Michigan, USA)
7:30 pm - 7:50 pmAndrea Ballabio (Telethon Institute of Genetics and Medicine, Italy)
"Lysosome-to-Nucleus Signaling"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:15 pmAmira Klip (University of Toronto, Canada)
"Insulin Transcytosis in Human Microvascular Endothelial Cells"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmJennifer Lippincott-Schwartz (Janelia Research Campus, Howard Hughes Medical Institute, USA)
"Mechanisms of Lipid Droplet Autophagy and Its Role in Yeast Lifespan Extension"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmBao-Liang Song (Wuhan University, China)
"Mechanisms of Intracellular Cholesterol Transport"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmStephane Camus (University College London, United Kingdom)
"CHC22 Clathrin Controls an Unconventional Secretory Pathway to Form the Insulin-Responsive GLUT4 Storage Compartment"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanisms of Lysosomal Degradation and Autophagy
Discussion Leaders: Olivia Majer (University of California, Berkeley, USA) and Christian Ungermann (University of Osnabrück, Germany)
9:00 am - 9:20 amMarkus Babst (University of Utah, USA)
"Regulation of Nutrient Transporters by Lipid Domains"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amVojo Deretic (University of New Mexico Health Sciences Center, USA)
"Autophagy - Multiple Relationships with Lysosomes"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amMark McNiven (Mayo Clinic, USA)
"Lipophagic Regulation by Large and Small GTPases"
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amHaoxing Xu (University of Michigan, USA)
"Ion Channels in the Lysosome: Opening the Gate to the Cell's Recycling Center"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amRichard Youle (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Downstream Steps of Mitophagy: Cargo-Centric Autophagosome Biogenesis and Lysosomal Fusion"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmPhyllis Hanson (Washington University School of Medicine in St. Louis, USA)
"New Functions for ESCRT-III?"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAmy Kiger (University of California, San Diego, USA)
"Rab2 Function in Autophagy and T-Tubule Membrane Remodeling"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmLate-Breaking Topics
Discussion Leaders: Tom Kirchhausen (Harvard Medical School, USA) and Lois Weisman (University of Michigan, USA)
7:30 pm - 7:50 pmToyoshi Fujimoto (Nagoya University Graduate School of Medicine, Japan)
"Lipids and Lipid Domains of the Yeast Vacuole"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmSrigokul Upadhyayula (Harvard Medical School, USA)
"Cellular Dynamics Imaged in Real Time and in 3D Using Lattice Light-Sheet Microscopy"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmChristophe Lamaze (Institut Curie, France)
"EHD2 Controls Breast Cancer Aggressiveness Through Caveolae Mechanotransduction"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmMary Munson (University of Massachusetts Medical School, USA)
"Architecture of the Yeast Exocyst Complex"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmChris Westlake (National Cancer Institute, NIH, USA)
"Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis Initiation"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLysosomes, and Lysosome-Related Organelles
Discussion Leaders: Robert Piper (University of Iowa, USA) and Angela Wandiger-Ness (University of New Mexico, USA)
9:00 am - 9:20 amNorma Andrews (University of Maryland, USA)
"Lysosomes and Endocytosis as Agents of Plasma Membrane Repair"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJuan Bonifacino (National Institute of Child Health and Human Development, NIH, USA)
"Mechanisms and Functions of Lysosome Positioning"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amRoberto Zoncu (University of California, Berkeley, USA)
"Molecular Mechanisms of Nutrient Sensing by the Lysosome"
10:15 am - 10:25 amDiscussion
10:25 am - 11:00 amCoffee Break
11:00 am - 11:20 amMichael Marks (Children's Hospital of Philadelphia, USA)
"Hermansky-Pudlak Syndrome and SNARE Dynamics During Melanosome Maturation"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amGraca Raposo (Institut Curie, France)
"Endocytosis-Exocytosis in Cell Cell Communication in Skin Pigmentation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmGillian Griffiths (Cambridge Institute for Medical Research, United Kingdom)
"Mechanisms Controlling Lysosomal Secretion in Immune Cells"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Organization and Function of the Endosomal System: From Cells to Tissues
Discussion Leader: Roberto Weigert (National Cancer Institute, NIH, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:45 pmMarino Zerial (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
"Molecular Mechanisms of Endosome Biogenesis, Tethering and Fusion"
8:45 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmGeneral Discussion
9:15 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA206290-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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