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Lysosomes and Endocytosis
Gordon Research Conference

Molecules, Pathways, and Physiology of Endosomes, Lysosomes and Lysosome-Related Organelles

Dates

June 17-22, 2018

Location

Proctor Academy
Andover, NH Site Information

Organizers

Chair:
Lois S. Weisman

Vice Chair:
Christopher G. Burd

Application Deadline

Applications for this meeting must be submitted by May 20, 2018. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The Gordon Research Conference on Lysosomes and Endocytosis will highlight recent advances in understanding the function and molecular regulation of endocytic trafficking pathways, biogenesis of lysosomes and related organelles, and the impact of these pathways on cell and organismal physiology. The inter-related network of organelles that constitute the endo-lysosomal system serves as a cellular entry point for nutrients, as well as pathogens. Recent research has revealed endosomes and lysosomes as hubs for inter- and intra-cellular signaling networks that control nutrient homeostasis, cell growth and differentiation, thus highlighting the remarkable degree to which these organelles regulate animal physiology. Moreover, as a degradative compartment, lysosomes provides a key line of defense against infection by parasites, viruses, as well as offer protection from the harmful effects of damaged organelles and misfolded proteins.

Topics of focus for the 2018 meeting include molecular mechanisms and cell biology of lysosomes, exosomes, and endocytic and degradative pathways, and the roles of these organelles and pathways in human health and disease. Sessions will cover molecular features of endocytic membrane traffic such as coat formation, membrane remodeling, functions of lipids, and on cell physiology including endosomal and lysosomal membrane traffic, autophagy and the formation of organelle contact sites. Other sessions will focus on the roles of endocytic pathways in diabetes and metabolism, neuronal biology, immunity, and regulation of signaling in cancer and finally, on mechanisms of endocytosis across different species. The conference will continue to feature a session on 'New Directions' in which novel technical and conceptual developments in the field will be discussed. The meeting is divided into nine half-day sessions, comprising a mixture of invited speakers and those selected from abstracts. Attendance by under-represented minorities, students, postdoctoral fellows, junior faculty, and faculty from primarily undergraduate institutions is encouraged.

Prior to, and in association with, the Gordon Research Conference, there will be a Gordon Research Seminar (GRS) on Lysosomes and Endocytosis for students and post-doctoral researchers. Junior researchers will present their work to each other in talks and posters. The GRS provides an excellent opportunity to develop collaborations and scientific relationships with peers prior to the arrival of more senior investigators. Interested trainees are encouraged to view the web site and to consider attending.

Related Meeting

This GRC will be held in conjunction with the "Lysosomes and Endocytosis" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Gordon Research Conferences
The Company of Biologists - Journal of Cell Science

Session Titles

The Conference will consist of nine sessions, on the topics listed below. The Conference Chair is currently developing their preliminary program, which will include the names of the invited speakers and discussion leaders for each of these sessions. The preliminary program will be available by November 15, 2017. Please check back for updates.

  • Lysosomes: Metabolism, Lipids, and Lysosomal Diseases
  • Lysosomal Biogenesis and Autophagy: Normal Pathways and Contributions to Neurological Disease
  • Endocytosis: Basic Mechanisms, Signaling, and Diabetes
  • Autophagy, Endocytosis and Exosomes: The Ins and Outs of Cancer and Immunity
  • Roles of the Endosomal Network in Organismal Physiology
  • Cellular Integration via Organelle Contact Sites and Phosphoinositide Signaling
  • Late-Breaking Topics
  • Sorting in the Endosomal Network
  • Keynote Session: Mechanisms of Membrane Fusion
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