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Mammalian DNA Repair
Gordon Research Conference

Frontiers of Mammalian Genomic Stability in Human Health

Dates

February 19-24, 2017

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chair:
Wei Yang

Vice Chair:
David Cortez

Meeting Description

The DNA in our cells constantly changes its structure and chemical composition in the course of endogenous processes and in response to exogenous challenges. The 2017 Mammalian DNA Repair GRC will expose researchers at all levels (faculty, researchers from industry, postdoctoral fellows, graduate students) to new frontiers of this rapidly progressing research field. DNA repair pathways are intimately linked to genome sequence and all aspects of DNA metabolism from replication, transcription to dynamic chromatin structural changes throughout the cell cycle. This meeting will focus on the balance between the normal cellular processes and DNA repair events in mammals to illustrate how genome integrity is safeguarded and what causes various types of instability and malady.

The speakers will outline new ideas, approaches and results at the frontiers of DNA mammalian repair. Many of the invited speakers are outstanding women scientists and young faculty. In addition, several long and many short talks will be selected from the abstract submissions. Trainees will have ample opportunities to give oral presentations and to lead and participate in both formal and informal discussions. We aim to have an open, lively and delightful atmosphere for scientific exchange and making personal connections.

Related Meeting

This GRC was held in conjunction with the "Mammalian DNA Repair" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Leading Edge in Mammalian DNA Repair
Discussion Leader: Philip Hanawalt (Stanford University, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:30 pmBik Tye (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Replication Licensing and DNA Unwinding: Structure and Function of Mcm2-7"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmDaniel Durocher (Lunenfeld-Tanenbaum Research Institute, Canada)
"Charting the Response to DNA Double-Streaks"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmDNA Damage and Repair: Longevity and Quality of Life
Discussion Leader: Samuel Wilson (National Institute of Environmental Health Sciences, NIH, USA)
9:00 am - 9:20 amJurgen Marteijn (Erasmus MC, The Netherlands)
"Regulation of Transcription Coupled Repair"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amSusanne Kassube (Friedrich Miescher Institute for Biomedical Research, Switzerland)
"Fe-S Cluster Biogenesis in DNA Repair Proteins: Structural Studies of the CIA Machinery"
9:40 am - 9:45 amDiscussion
9:45 am - 10:05 amCaroline Kisker (University of Wuerzburg, Germany)
"RecQ4, the Odd One Out in the RecQ Helicase Family"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amPriscilla Cooper (Lawrence Berkeley National Laboratory, USA)
"Dual Roles of XPG in Regulating BRCA1 and BRCA2 Functions in Homologous Recombination"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amHemmo Meyer (University of Duisburg-Essen, Germany)
"The AAA-ATPase VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double Strand Break Repair"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amOrlando Scharer (Ulsan National Institute of Science and Technology (UNIST), South Korea)
"Are TLS Polymerases Absolutely Required for Interstrand Crosslink Repair?"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFrom Basic Mechanism to Lethal Weapons
Discussion Leader: Caroline Kisker (University of Wuerzburg, Germany)
7:30 pm - 7:50 pmSamuel Wilson (National Institute of Environmental Health Sciences, NIH, USA)
"New Insight on DNA Polymerase Mechanism from Chemical and Structural Biology"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmLi Lan (University of Pittsburgh, USA)
"Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmJudith Campbell (California Institute of Technology, USA)
"Regulation of DNA2 in DNA Repair"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmKeith Wilcoxen (TESARO, Inc., USA)
"Targeting Cancers with DNA Repair: Beyond BRCA"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmThomas Helleday (Karolinska Institutet, Sweden)
"Targeting MTH1 to Poison DNA with Oxidized Nucleosides: Beyond Cancer"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmReplication Fork Progression and Mutation Avoidance
Discussion Leader: David Cortez (Vanderbilt University School of Medicine, USA)
9:00 am - 9:20 amGrant Stewart (University of Birmingham, United Kingdom)
"Identification of a Novel Replication Fork Protection Factor that Is Mutated in Microcephalic Primordial Dwarfism"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAnthony Carr (University of Sussex, United Kingdom)
"Mechanism of Replication-Associated Genome Rearrangement"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amBinghui Shen (City of Hope, USA)
"DNA2 Facilitates Centromeric DNA Replication for Human Genome Stability"
10:10 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amAgata Smorgorzewska (Rockefeller University, USA)
"DNA Damage Response During Replication Stress"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amRichard Pomerantz (Lewis Katz School of Medicine, Temple University, USA)
"Reconstitution of RNA Transcript-Mediated DNA Recombinational Repair"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amGuo-Min Li (University of Southern California, USA)
"Deciphering the Sliding Activity of MutS Family Proteins in Mismatch Repair"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmAlessandro Vindigni (Saint Louis University, USA)
"Homologous Recombination Factors in Replication Stress Response"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSelected Poster Presentations: The Frontiers of Mammalian DNA Repair in 2017
Speakers in this session were selected from abstract submission.
Discussion Leader: Karlene Cimprich (Stanford University School of Medicine, USA)
7:30 pm - 7:50 pmLee Zou (Massachusetts General Hospital Cancer Center, Harvard University, USA)
"Coupling of Homologous Recombination and the Checkpoint Response by ATR"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmGraham Walker (Massachusetts Institute of Technology, USA)
"Mutagenic Translesion DNA Synthesis and Chemotherapy"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDipanjan Chowdhury (Dana Farber Cancer Institute, USA)
"TIRR, a New Player in DSB Repair, Regulates 53BP1 Activity by Masking Its Methyl-Lysine Binding Function"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmXiaoliang Sunney Xie (Harvard University, USA)
"Single Cell Whole Genome Sequencing: Insights for Mammalian DNA Damage and Repair"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDNA Damage Signaling and Repair Coordination
Discussion Leader: Tanya Paull (University of Texas at Austin, USA)
9:00 am - 9:20 amRoger Greenberg (University of Pennsylvania, USA)
"Alternative Mechanisms of Homology Directed DNA Repair"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amPetr Cejka (Institute for Research in Biomedicine, Switzerland)
"Phosphorylated CtIP Functions as a Co-Factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection"
9:40 am - 9:45 amDiscussion
9:45 am - 10:05 amShan Zha (Columbia University, USA)
"Role of ATM, DNA-PKcs and ATR in DNA Repair – Reach Beyond Signaling"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 10:55 amXiaohua Wu (The Scripps Research Institute, USA)
"Sequential Phosphorylation of Mre11 by ATM and ATR Is Important for DNA Damage Responses"
10:55 am - 11:00 amDiscussion
11:00 am - 11:20 amKarlene Cimprich (Stanford University School of Medicine, USA)
"RNA Meets DNA: Transcription-Mediated Genome Instability"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amZhenkun Lou (Mayo Clinic, USA)
"Ubiquitination Signaling in Double Strand Break Repair"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmSimon Boulton (The Francis Crick Institute, United Kingdom)
"Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMechanisms for DNA Double-Strand Break Repair
Discussion Leader: Roger Greenberg (University of Pennsylvania, USA)
7:30 pm - 7:50 pmEric Greene (Columbia Univeristy, USA)
"Single Molecule Studies of Homologous DNA Recombination"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAndre Nussenzweig (National Cancer Institute, NIH, USA)
"Synthetic Viability and Lethality in BRCA Deficient Cells"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmTanya Paull (University of Texas at Austin, USA)
"Characterization of DNA Double-Strand Break Repair in Human Cells"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmIlya Finkelstein (University of Texas at Austin, USA)
"Single-Molecule Views of Eukaryotic DNA Resection"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromatin Structures and Genome Stability
Discussion Leader: Alan D'Andrea (Dana-Farber Cancer Institute, USA)
9:00 am - 9:20 amKyle Miller (University of Texas at Austin, USA)
"Regulation of DNA Repair Within the Chromatin Environment"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amSophie Polo (CNRS UMR7216, Paris Diderot University, France)
"Epigenome Maintenance in Response to DNA Damage"
9:40 am - 9:45 amDiscussion
9:45 am - 10:05 amJessica Downs (Institute of Cancer Research, United Kingdom)
"The PBAF Chromatin Remodelling Complex and the Maintenance of Genome Stability"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amPatricia Opresko (University of Pittsburgh, USA)
"Uncovering How Oxidative DNA Damage Influences Telomere Maintenance"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amKamakoti Bhat (Vanderbilt University, USA)
"RADX Promotes Replication Fork Stability and Modulates Chemosensitivity by Regulating RAD51"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amKaren Usdin (National Institutes of Health, USA)
"The Dark Side of DNA Repair: Repeat Expansion in the Fragile X-Related Disorders"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmAgnel Sfeir (New York University Langone Medical Center, USA)
"Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCrosslinks and Cross Talk
Discussion Leader: Patricia Opresko (University of Pittsburgh, USA)
7:30 pm - 7:50 pmMichael Seidman (Laboratory of Molecular Gerontology, National Institute on Aging, NIH, USA)
"Replication Fork Encounters with Absolute Blocks to Replication"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmPierre-Henri Gaillard (Cancer Research Center of Marseille, CNRS, France)
"Physical and Functional Interactions Between SLX4 and RTEL1"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmScott Williams (National Institute of Environmental Health Sciences, NIH, USA)
"Resolution of Topoisomerase DNA-Protein Crosslinks"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmMarkus Lobrich (Darmstadt University of Technology, Germany)
"ATRX Cooperates with PCNA During Homologous Recombination"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmAlan D'Andrea (Dana-Farber Cancer Institute, USA)
"Chromatin Modifications at the Stalled Replication Fork"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA213969-01 from the National Cancer Institute (NCI), the National Institute on Aging (NIA) and the National Institutes of Environmental Health Sciences (NIEHS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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