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Marine Natural Products
Gordon Research Conference

Insights into Marine Natural Products from the Field, Lab and Clinic

Dates

March 6-11, 2016

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chair:
Julia Kubanek

Vice Chair:
Paul R. Jensen

Meeting Description

The 2016 Gordon Research Conference on Marine Natural Products will bring together early career and established researchers from academia, industry, and government to address the discovery and development of natural products from marine ecosystems. Presentations and discussion will focus on diverse topics including the biosynthetic origin of marine natural products and how organismal interactions control production; how natural products modulate cellular networks and present opportunities to treat human disease; applications of natural product research to medicine and marine conservation; and cutting-edge techniques in natural product structure elucidation and synthesis. Presentations focusing on terrestrial systems are also included as many themes are paralleled in marine organisms and habitats. A Gordon Research Seminar preceding the Conference will build expertise and communication among early career researchers, with several researchers selected to deliver short talks at the Conference based on their GRS presentations. The collegial atmosphere of this Conference will facilitate new collaborations, training opportunities for early career scientists, and the exchange of ideas among leaders in the field and new attendees.

Related Meeting

This GRC was held in conjunction with the "Marine Natural Products" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmGenetically Encoded Small Molecules from Marine Organisms
Discussion Leader: Shigeki Matsunaga (The University of Tokyo, Japan)
7:40 pm - 8:00 pmOpening Remarks: Introduction by the GRC Chairs and a Brief Recap of the GRS by the GRS Chairs
8:00 pm - 8:40 pmBradley Moore (Scripps Institution of Oceanography, USA)
"Biosynthetic Gene Clusters - Nature's Gift to Discovery and Application"
8:40 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmTal Luzzatto-Knaan (University of California, San Diego, USA)
"Chemodiversity Based Cartography of Natural Products from Marine Communities"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmSynthetic Biology of Natural Products
Discussion Leader: Mohamed Donia (Princeton University, USA)
9:00 am - 9:30 amEmily Balskus (Harvard University, USA)
"Chemical Discovery in the Microbial World"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amEric Schmidt (University of Utah, USA)
"Novel Neuroactive Marine Natural Products"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amSelected from Poster Abstracts: Jason Kwan (University of Wisconsin-Madison, USA)
"Using Shotgun Metagenomics to Investigate Natural Products from Uncultured Bacteria in Marine Invertebrates"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: Xinyu Liu (University of Pittsburgh, USA)
"An Emerging View of Hapalindole-Type Alkaloid Biogenesis"
11:25 am - 11:30 amDiscussion
11:30 am - 12:10 pmSarah O'Connor (John Innes Centre, United Kingdom)
"Understanding How Nature Makes Nitrogen-Containing Natural Products: Elucidating and Engineering Alkaloid Pathways from Plants"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Lena Gerwick (University of California, San Diego, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMolecular Targets and Omics Approaches
Discussion Leader: Roberto Berlinck (University of Sao Paulo, Brazil)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:20 pmLeticia Costa-Lotufo (University of Sao Paulo, Brazil)
"Prospecting Anticancer Compounds on the Brazilian Coast: From Simple to Complex and Back"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmCarole Bewley (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Anti-Infectives from Nature: Identifying Targets and Elucidating Mechanisms"
9:15 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOrganismal Interactions in Wet and Not-so-Wet Worlds
Discussion Leader: Amy Lane (University of North Florida, USA)
9:00 am - 9:30 amToshiyuki Wakimoto (Hokkaido University, Japan)
"Activated Chemical Defense of a Sponge-Microbe Association"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amDanielle Dixson (University of Delaware, USA)
"The Importance of Including Chemically Mediated Behavior in Creating Effective Marine Management"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amSelected from Poster Abstracts: Jessie Ochoa (University of California, Santa Cruz, USA)
"Phylogenetic and Metabolomic Analysis Contributes to Emerging Spirotetronate Polyketides"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: Kristen Whalen (Woods Hole Oceanographic Institution, USA)
"Louder than Words: Bacterial Cell Signals Are Drivers of Algal Lysis"
11:25 am - 11:30 amDiscussion
11:30 am - 12:10 pmMartin Kaltenpoth (Johannes Gutenberg University of Mainz, Germany)
"Evolution and Chemical Ecology of Defensive Microbial Symbioses in Insects"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAntibiotic Discovery and Microbial Secondary Metabolism
Discussion Leader: Brian Murphy (University of Illinois at Chicago, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:20 pmMohammad Seyedsayamdost (Princeton University, USA)
"Unveiling the Hidden Secondary Metabolomes of Bacteria"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmStefan Schulz (Technische Universität Braunschweig, Germany)
"Volatiles from Marine Bacteria"
9:15 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCreative Chemical Solutions to Mysterious Molecules
Discussion Leader: Tim Bugni (University of Wisconsin-Madison, USA)
9:00 am - 9:30 amTadeusz Molinski (University of California, San Diego, USA)
"Integrated Approaches for Discovery of Bioactive Natural Products from Marine Invertebrates"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amRichmond Sarpong (University of California, Berkeley, USA)
"New Strategies and Methods for the Synthesis of Marine Alkaloids"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amSelected from Poster Abstracts: Thomas Williamson (Merck & Co. Inc., USA)
"Small Molecule Structure Characterization: New and Improved NMR Methods"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: Danmeng Luo (University of Florida, USA)
"Total Synthesis of the Potent Marine-Derived Elastase Inhibitor Lynbyastatin 7 and In Vitro Biological Evaluation in Model Systems for Pulmonary Diseases"
11:25 am - 11:30 amDiscussion
11:30 am - 12:10 pmKirk Gustafson (National Cancer Institute, NIH, USA)
"Interesting New Structures and How We Can Solve Them: Application of Contemporary Structural Elucidation Techniques"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMicrobial Signaling in a Vast Ocean
Discussion Leader: David Rowley (University of Rhode Island, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:20 pmTracy Mincer (Woods Hole Oceanographic Institution, USA)
"Listening in on Microbial Natural Product Production Under Perturbation: Towards Understanding Global Cellular Production of Secondary Metabolites"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmGeorg Pohnert (Friedrich-Schiller-Universität Jena, Germany)
"Gradients and Events: The Chemistry of Plankton Interactions"
9:15 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTargeting Human Disease with Natural Products
Discussion Leader: Yali Fu (National Cancer Institute, NIH, USA)
9:00 am - 9:30 amAnokha Ratnayake (Pfizer, USA)
"The Process of Designing and Developing Natural Products-Based Antibody Drug Conjugates for the Treatment of Cancer"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amRobert Capon (University of Queensland, Australia)
"Exploring Microbial Chemical Ecology as a Pathway for Accessing Silent Secondary Metabolism"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amSelected from Poster Abstracts: Samantha Mascuch (Georgia Institute of Technology, USA)
"Mechanism of Action of the Cyanobacterial Marine Natural Product Honaucin A"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: James Anson (Royal Society of Chemistry, United Kingdom)
"Marine Natural Products Review Article: A New Look for 2016"
11:25 am - 11:30 amDiscussion
11:30 am - 12:10 pmJohn MacMillan (University of Texas Southwestern Medical Center, USA)
"Microbial Natural Products with Selective Activity Against Non-Small Cell Lung Cancer"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Development of Marine Natural Products as Pharmaceuticals and Tools for Research
Discussion Leader: Paul Jensen (Scripps Institution of Oceanography, USA)
7:30 pm - 7:45 pmOpening Remarks
7:45 pm - 8:15 pmEduardo Esquenazi (Sirenas Marine Discovery, USA)
"A Small Company's Perspective on Opportunities for Marine Inspired Drug Discovery and Development in Today's Pharma Environment"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmRonald Quinn (Griffith University, Australia)
"Towards the Bedside: The Journey from 10 kg Marine Organism and Animal Screening to Molecular Targets to Patient-Derived Cells"
9:10 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13AT009147-01 from the National Center for Complementary and Integrative Health (NCCIH). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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