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Mechanisms of Membrane Transport
Gordon Research Conference

From Structure and Dynamics to Energy Landscapes and Personalized Medicine

Dates

June 25-30, 2017

Location

Colby-Sawyer College
New London, NH

Organizers

Chair:
Hassane S. Mchaourab

Vice Chairs:
Olga Boudker & Simon Newstead

Meeting Description

The 2017 edition of the Gordon Conference on Mechanisms of Membrane Transport will continue the tradition of this conference focusing on cutting edge research in the field of membrane channels and transporters with particular emphasis on their mechanisms of action. Planned sessions will highlight newly developing approaches to integrate structure, dynamics and function of these proteins in the context of energy landscapes and illustrate their applications in understanding mechanisms of diseases. A dedicated session will showcase recent advances in the cryoEM analysis to gain insight into large multimeric/oligomeric channels and transporters.

The Conference has consistently provided a forum for young scientists to showcase their research achievements through oral presentations integrated into the program along with the lectures from established leaders in the field. In addition, the daily poster sessions allow ample time for free and informal discussions, networking and inception of new collaborations. We are excited to announce that the second edition of the Mechanisms of Membrane Transport Gordon Research Seminar will immediately precede the Conference. It will build on the resounding success of the first GRS held in 2015 providing young trainees with opportunities for additional interactions, career and scientific discussions with their peers.

We strongly encourage Conference applications from both junior and senior scientists from overseas, from minorities, and from those with disabilities. We are applying for funds to offset costs to those with financial constraints.

Related Meeting

This GRC was held in conjunction with the "Mechanisms of Membrane Transport" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmStructure and Mechanisms of ABC Transporters
Discussion Leader: Heather Pinkett (Northwestern University, USA)
7:40 pm - 8:05 pmJochen Zimmer (University of Virginia School of Medicine, USA)
"ABC Transporters Implicated in Biopolymer Translocation"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmMaofu Liao (Harvard Medical School, USA)
"Cryo-EM Studies of an ATP-Binding Cassette Lipid Transporter"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmKonstantinos Beis (Imperial College London, United Kingdom)
"Structural Basis for Antibacterial Peptide Self-Immunity by Bacterial ABC Transporters"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmZachary Johnson (The Rockefeller University, USA)
"Cryo-EM Snapshots of Substrate Recognition by the Multidrug Resistance Transporter MRP1"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmForefront of Structural Biology of Transport
Discussion Leader: Crina Nimigean (Weill Cornell Medicine, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amEric Gouaux (Vollum Institute, Oregon Health and Science University, USA)
"Structure and Mechanism of Neurotransmitter Sodium Symporters"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amRobert Tampe (Goethe-University Frankfurt, Germany)
"Antigens on the Move – New Twists and Turns in Adaptive Immunity"
10:05 am - 10:15 amDiscussion
10:15 am - 10:40 amCoffee Break
10:40 am - 11:05 amCameron Noland (Genentech, USA)
"Structural Insights into Bacterial Lipoprotein Biosynthesis"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amVera Moiseenkova-Bell (Case Western Reserve University, USA)
"New Insight into the Structure of TRPV Channels"
11:40 am - 11:50 amDiscussion
11:50 am - 12:00 pmHuaizong Shen (Tsinghua University, China)
"Structure of a Eukaryotic Voltage-Gated Sodium Channel at Near Atomic Resolution"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmAltin Sula (Birkbeck, University of London, United Kingdom)
"The Complete Structure of an Activated Open Voltage Gated Sodium Channel Reveals a Novel Gating Interaction Motif"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Rajini Rao (Johns Hopkins University, USA) and Karen Fleming (Johns Hopkins University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLiving in the Lipid Bilayer
Discussion Leader: Cedric Govaerts (Free University of Brussels, Belgium)
7:30 pm - 7:55 pmChristine Ziegler (University of Regensburg, Germany)
"Impact of Specific Lipids on Membrane Transport, Two Sides of the Same Coin?"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmJanice Robertson (The University of Iowa, USA)
"Measuring the Free Energy of ClC-ec1 Dimerization in Membranes Using Single-Molecule Photobleaching Analysis"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmArthur Laganowsky (Texas A&M University, USA)
"Probing Membrane Protein-Lipid Interactions by Native Ion Mobility Mass Spectrometry"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmShannon Mostyn (University of Sydney, Australia)
"Heads or Tails: Lipid Inhibitors of the Glycine Transporter, GlyT2"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStructure, Dynamics and Mechanisms of Secondary Transporters
Discussion Leader: Merritt Maduke (Stanford University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amJoseph Mindell (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Multimodal Approach to Understanding clc-7 Function in Lysosomes"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amNicolas Reyes (Institut Pasteur, France)
"Structural and Dynamic Studies of Excitatory Amino Acid Transporters"
10:05 am - 10:15 amDiscussion
10:15 am - 10:40 amDavid Drew (Stockholm University, Sweden)
"Lipids and Proton Transport in Na+/H+ Antiporters"
10:40 am - 10:50 amDiscussion
10:50 am - 11:20 amGroup Photo / Coffee Break
11:20 am - 11:45 amSusan Buchanan (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Structural Insight into the Role of the Ton Complex in Transport Across the Outer Membrane"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmJeff Abramson (University of California, Los Angeles, USA)
"Deciphering Ligand Induced Conformational Changes in the Sodium Galactose Transporter (SGLT)"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIon Interactions with Membrane Proteins
Discussion Leader: Shimon Schuldiner (Hebrew University of Jerusalem, Israel)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmKatherine Henzler-Wildman (University of Wisconsin-Madison, USA)
"EmrE Sacrifices Coupling Efficiency to Achieve Multidrug Promiscuity"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmNate Traaseth (New York University, USA)
"Probing the Structure and Ion-Coupled Mechanism of the Multidrug Transporter EmrE Using NMR Spectroscopy"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmGerard Huysmans (Weill Cornell Medicine, USA)
"Exploring Protein Sequence Information Across Nature's Hot and Cold Habitats to Understand the Functional Dynamics in the Glutamate Transporter Family"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmThomas Stockner (Medical University of Vienna, Austria)
"Oligomer Interfaces of the Human Dopamine Transporter"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEnergy Landscapes of Membrane Transport Proteins
Discussion Leader: Dirk Jan Slotboom (University of Groningen, The Netherlands)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amEmad Tajkhorshid (University of Illinois at Urbana-Champaign, USA)
"Multidimensional Free Energy Landscape Governing Structural Transitions of a Neurotransmitter Transporter in Membrane"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amJose Faraldo-Gomez (National Institutes of Health, USA)
"The Dos and Don'ts of Active Transporters: An Energy Landscape Perspective"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:10 amScott Blanchard (Weill Cornell Medical College, USA)
"Imaging Functional Dynamics Within Individual Transporter Proteins Using Single-Molecule FRET"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amBaron Chanda (University of Wisconsin-Madison, USA)
"Single Molecule Studies Reveal Ligand Binding Dynamics in Pacemaker Ion Channels"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmKaren Fleming (Johns Hopkins University, USA)
"Driving Forces for Folding Membrane Proteins"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmLigand-Gated Channels: Recent Updates
Discussion Leader: Lucy Forrest (National Institute of Neurological Disorders and Stroke, NIH, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmSudha Chakrapani (Case Western Reserve University, USA)
"Allosteric Mechanisms Underlying Pentameric Ligand-Gated Ion Channel Modulation"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmVisanthi Jayaraman (University of Texas Health Science Center at Houston, USA)
"Structure and Energy Landscapes of Ionotropic Glutamate Receptor"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmWeronika Stanek (University of Groningen, The Netherlands)
"Competition Between S-Components for a Common Energizing Module"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIon Channels: Structure and Function
Discussion Leader: Eduardo Perozo (University of Chicago, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amShow-Ling Shyng (Oregon Health and Science University, USA)
"Insights into the Mechanisms of KATP Channel Assembly and Gating from Cryo-EM Structures"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amLiz Carpenter (University of Oxford, United Kingdom)
"Structures of K2P and TRPP Channels by X-Ray, xFEL and Cryo-EM"
10:05 am - 10:15 amDiscussion
10:15 am - 10:40 amCoffee Break
10:40 am - 11:05 amAlexander Sobolevsky (Columbia University, USA)
"Studies of the Epithelial Calcium Channel TRPV6"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amLucie Delemotte (Science for Life Laboratory, Sweden)
"Exploring the Complex Dynamics of an Ion Channel Voltage Sensor Domain via Computation"
11:40 am - 11:50 amDiscussion
11:50 am - 12:00 pmMarina Diskowski (Goethe University Frankfurt, Germany)
"Helical Jackknives Control the Double-Pore K+ Uptake System KtrAB"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmValeria Vasquez (University of Tennessee Health Science Center, USA)
"Omega-3 Polyunsaturated Fatty Acids Enhance Human Endothelial Cells Response by Recruiting Transient Receptor Potential Channels"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPersonalized Medicine: Disease-Causing Mutations in Channels and Transporters
Discussion Leader: Ute Hellmich (Johannes Gutenberg University of Mainz, Germany)
7:30 pm - 7:55 pmAurelio Galli (Vanderbilt University, USA)
"Failure to Prime the Dopamine 'Pump' in Autism"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmGaia Novarino (Institute of Science and Technology, Austria)
"Mutations in the Neutral Amino Acid Transporter LAT1 Are a Cause of Microcephaly and Autism"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmHanne Poulsen (Aarhus University, Denmark)
"Murphy's Law of the Sodium Pump"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS101878. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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