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Metals in Biology
Gordon Research Conference

How to Solve Biologically-Inspired, Metal-Related Problems

Dates

January 24-29, 2016

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chair:
Joanne Stubbe

Vice Chair:
R. David Britt

Meeting Description

While your Vitamin bottle label predominantly highlights the importance of the precursors to the organic cofactors that greatly expand the repertoire of reactions accessible to enzymes, the "minerals" usually reside at the bottom of the label. Metals however are equally essential and provide a playground for the investigation of unprecedented enzymatic reactions that range from light mediated oxidation of water to O2 and H+ to H2 of current interest in the green energy movement, to the reduction of N2 to NH3 central to the global N cycle. Such enzymes are the inspiration for chemists to invent new small molecules that can mediate multielectron processes. Metals with protein scaffolds have evolved creative ways of functionalizing unactivated C-H bonds without the need for blocking groups. They also orchestrate using self-assembly, often with the aid of proteins, shell formation of the sea creatures, generation of compasses within magnetobacteria or removal of radioactivity from the environment. These amazing biomaterials are an inspiration for designing new materials with unprecedented properties. In addition, the ability to evolve new catalytic activities from "old" metallo-enzymes or to design protein scaffolds to bind organo-metallic cofactors that can function in an aqueous environment suggest an exciting future. The large number of unusual metallo-cofactors, still being discovered, provide inspiration for chemists to generate small molecule catalysts to efficiently produce important commodity chemicals, new ways to use biomass, etc.

Cisplatin remains the most effective cancer therapeutic and provides inspiration for new ways to incorporate metals into useful therapeutics. The field of metals in biology is very broad and very exciting and attracts chemists, biochemists, biologists, material scientists, and physicists to solve the current and future problems society faces.

Please join us at the 2016 GRC in Metals in biology to find new multidisciplinary ways to solve your biologically inspired, metal-related problems.

Related Meeting

This GRC was held in conjunction with the "Bioinorganic Chemistry" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCopper Reactivity: Models to Enzymes
Discussion Leader: Leslie Murray (University of Florida, USA)
7:40 pm - 8:20 pmEdward Solomon (Stanford University, USA)
"Dioxygen, Binding, Activation and Reduction by Copper Proteins"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmKenneth Karlin (Johns Hopkins University, USA)
"Elaboration of Single-Copper Site Dioxygen Chemistry"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmProtein Design
Discussion Leader: Donald Hilvert (ETH Zurich, Switzerland)
9:00 am - 9:30 amDonald Hilvert (ETH Zurich, Switzerland)
"Computational Design and Laboratory Evolution of Metalloenzymes"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amAnastassia Alexandrova (University of California, Los Angeles, USA)
"Computational Metalloenzyme Design Through Multi-Scale Modeling"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amAkif Tezcan (University of California, San Diego, USA)
"Evolution of Inorganic Reactivity in Biological Scaffolds"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmFrances Arnold (California Institute of Technology, USA)
"Directed Evolution of New Enzymes"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMetal Sensors: Design, Issues and What We Have Learned
Discussion Leader: Christoph Fahrni (Georgia Institute of Technology, USA)
7:30 pm - 8:00 pmStephen Lippard (Massachusetts Institute of Technology, USA)
"Mobile Zinc Signaling in the Brain - Learning, Memory, Hearing, Olfaction, and Vision"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmYi Lu (University of Illinois, USA)
"Overcoming Major Barriers to Developing Successful Biosensors for Metal Ions"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmChristopher Chang (University of California, Berkeley, USA)
"Molecular Imaging Approaches to Studying Metal and Redox Biology in the Brain"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNon-Heme Iron Chemistry
Discussion Leader: Aimin Liu (University of Texas at San Antonio, USA)
9:00 am - 9:30 amWilfred van der Donk (Howard Hughes Medical Institute / University of Illinois at Urbana-Champaign, USA)
"A Tale of Two Proteins: Hydroxyethylphosphonate Dioxygenase and Methylphosphonate Synthase"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amPinghua Liu (Boston University, USA)
"Endoperoxide Formation Catalyzed by FtmOx1: An Alpha-Ketoglutarate Dependent Non-Heme Enzyme"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amWenjun Zhang (University of California, Berkeley, USA)
"Non-Heme Iron Enzymes for Terminal Alkene and Alkyne Synthesis"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmGrace Kenney (Northwestern University, USA)
"A New Metalloenzyme Complex Involved in Natural Product Biosynthesis"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMetals and Innate Immunity
Discussion Leader: Katherine Franz (Duke University, USA)
7:30 pm - 8:00 pmElizabeth Nolan (Massachusetts Institute of Technology, USA)
"Human Innate Immunity and Microbial Pathogenesis"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmMichael Pluth (University of Oregon, USA)
"Reactions of Isolated Persulfides with Reactive Sulfur and Nitrogen Species"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmDeborah Perlstein (Boston University, USA)
"Piecing Together Apo-Target Recognition in Cytosolic Iron Sulfur Cluster Biosynthesis"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAmit Reddi (Georgia Institute of Technology, USA)
"Heme Gazing: Elucidating Heme Trafficking and Signaling with Fluorescent Heme Sensor"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetals in the Enviroment: Biology, Engineering, and Remediation
Discussion Leader: Michelle Chang (University of California, Berkeley, USA)
9:00 am - 9:30 amDaniel Nocera (Harvard University, USA)
"Metabolically Engineered Organisms for Energy Conversion"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amGemma Reguera (Michigan State University, USA)
"How to Train Your Microbe to Clean Up Toxic Metals"
10:15 am - 10:30 amDiscussion
10:30 am - 11:10 amCoffee Break
11:10 am - 11:40 amArash Komeili (University of California, Berkeley, USA)
"Molecular Mechanisms of Magnetite Biomineralization in Diverse Microorganisms"
11:40 am - 11:55 amDiscussion
11:55 am - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNew B12 Chemistry
Discussion Leader: Catherine Drennan (Massachusetts Institute of Technology, USA)
7:30 pm - 8:15 pmDavid Leys (University of Manchester, United Kingdom)
"Reductive Dehalogenases and Beyond: New Roles for B12"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmVahe Bandarian (University of Utah, USA)
"A New Role for an Old Cofactor: Role of B12 in a tRNA Modification"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmJennifer Bridwell-Rabb (Massachusetts Institute of Technology, USA)
"Biosynthesis of a Novel Nucleoside: Are Two Metals Better than One?"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmParamagnetic and Biochemical Methods to Study Metallo-Enzymes
Discussion Leader: Joan Broderick (Montana State University, USA)
9:00 am - 9:30 amBrian Hoffman (Northwestern University, USA)
"Mechanism of Biological Nitrogen Fixation"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amMarina Bennati (University of Gottingen, Germany)
"Recent Advances in EPR Spectroscopy: Unraveling the Hydrogen Bond Network and Rradical Intermediates in Class Ia RNR"
10:15 am - 10:30 amDiscussion
10:30 am - 11:10 amCoffee Break
11:10 am - 11:40 amR. David Britt (University of California, Davis, USA)
"Mechanisms of Solar Fuel Reactions as Probed by Advanced EPR Spectroscopy (FeFe Hydrogenase Assembly and Perhaps Some Photosystem II OEC)"
11:40 am - 11:55 amDiscussion
11:55 am - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmJoint Session with the Gordon Research Seminar: RNRs Diverse Metallo-Cofactors Essential Deoxynucleotide Biosynthesis
Discussion Leader: Joseph Martin Bollinger (Pennsylvania State University, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:15 pmAmie Boal (Pennsylvania State University, USA)
"Metallocofactor Assembly in a Novel Manganese-Dependent Class I Ribonucleotide Reductase"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:15 pmBritt-Marie Sjoberg (Stockholm University, Sweden)
"On the Evolution of Ribonucleotide Reductases"
9:15 pm - 9:30 pmDiscussion
9:30 pmJoint Poster Session with the Gordon Research Seminar
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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