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Muscle: Excitation-Contraction Coupling
Gordon Research Conference

Emerging Concepts on E-C Coupling Relating Basic Mechanisms to New Therapies

Dates

June 4-9, 2017

Location

Les Diablerets Conference Center
Les Diablerets, Switzerland

Organizers

Chairs:
Isabelle Marty & Héctor Valdivia

Vice Chair:
Filip Van Petegem

Meeting Description

The first objective of the meeting is to discuss and critically evaluate new breakthroughs regarding the molecular mechanisms that control excitation-contraction coupling (ECC), how this process is altered in genetically-inherited forms of skeletal and cardiac muscle disease, and in muscle fatigue, atrophy, sarcopenia, and how therapeutic intervention could reverse these alterations. The second objective is to promote visibility and leadership of junior investigators in the field by providing a platform for students, postdoctoral fellows, and new independent investigators to present their work, as well as to interact and network with established senior investigators. Scientific sessions will focus on structural studies of the ECC apparatus, new insights into the molecular mechanisms and regulation of ECC, identification of new therapeutic targets, and the development of innovative treatments for skeletal and cardiac muscle disorders with alteration in EEC. For the second time for this GRC, the meeting will be preceded by a two-day Gordon Research Seminar (GRS) for graduate students and postdoctoral fellows. In addition, for each session during the GRC, a young investigator will be paired with a senior investigator to serve as Co-Discussion Leaders. Innovative "Poster Preview" and "Late-Breaking Topic" speaker slots will be used to highlight late-breaking news. These innovative program elements will also maximize poster session visibility, as well as enhance the integration and exposure of promising young investigators in the field during the GRC. The overall aim is to promote: 1) open dialogue and communication, 2) exposure and career advancement of promising young investigators in the field, 3) fundamental understanding in the mechanisms of ECC and how defects in this process lead to compromised skeletal and cardiac muscle performance, and 4) the development of novel and effective therapies to combat skeletal and cardiac muscle disorders affecting excitation-contraction coupling.

Related Meeting

This GRC was held in conjunction with the "Muscle: Excitation-Contraction Coupling" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmWhat's New in Calcium Channels Structure?
Discussion Leader: Filip Van Petegem (University of British Columbia, Canada)
7:40 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:10 pmOliver Clarke (Columbia University, USA)
"Structural Studies of RyR1 Gating"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmWayne Chen (University of Calgary, Canada)
"Structure of RyR2"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmJianping Wu (Tsinghua University, China)
"Structure of CaV1.1"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmHanting Yang (Institute of Biophysics, Chinese Academy of Sciences, China)
"Pore Architecture and Gating Mechanism of TRIC Channels"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAssembly and Maintenance of the Triad/Dyad
Discussion Leader: Eduardo Rios (Rush Medical College, Rush University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amRobin Shaw (Cedars-Sinai Medical Center / University of California, Los Angeles, USA)
"The Role of BIN1 in DHPR Traffic and Regulation of Dyad Associated Microdomains"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amEdgar Gomes (Instituto de Medicina Molecular (IMM), Portugal)
"Mechanisms of Triad Formation and Nuclear Positioning in Skeletal Muscle"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amBenjamin Prosser (University of Pennsylvania, USA)
"Microtubule Modulation of Cardiomyocyte Contraction"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:25 amLong-Sheng Song (University of Iowa, USA)
"Junctophilin-2 and Cardiac T-Tubule Organization"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amStephen Cannon (David Geffen School of Medicine at UCLA, USA)
"Stac3 Enhanced Expression of Human CaV1.1 in Xenopus Oocytes to Characterize HypoPP Mutant Channels"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amJulien Fauré (Université Grenoble Alpes, France)
"Triadin Trafficking in Sarcoplasmic Reticulum Sub-Domains"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmGroup Photo / Lunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Susan Hamilton (Baylor College of Medicine, USA) and Clara Franzini-Armstrong (University of Pennsylvania, USA)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmSecondary Alteration of EC Coupling in Myopathies and Cardiac Diseases
Discussion Leader: Donald Bers (University of California, Davis, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmKarin Sipido (KU Leuven, Belgium)
"E-C Coupling and Microdomain Signaling in Ischemic Cardiomyopathy"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmEster Zito (Istituto di Ricerche Farmacologiche Mario Negri, Italy)
"Regulation of SERCA Pump Activity in SEPN1-Related Myopathies"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:30 pmDaniel Michele (University of Michigan, USA)
"Sarcolemma Integrity and Muscle Dysfunction in Dystrophic Muscle"
7:30 pm - 7:40 pmDiscussion
7:40 pm - 7:50 pmDaphne Atlas (The Hebrew University of Jerusalem, Israel)
"The Voltage-Gated Calcium Channel Is the Ca2+ Sensor of Cardiac Contraction"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmConvergent/Divergent Mechanisms and Phenotypes in Related Disorders
Discussion Leader: Nagomi Kurebayashi (Juntendo University, Japan)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amPhil Hopkins (Leeds Institute of Biomedical and Clinical Sciences, United Kingdom)
"MH and Exertional Heat Stroke"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amKevin Tylock (University of Rochester Medical Center, USA)
"Molecular and Physiological Mechanisms for QRS- and QT-Interval Prolongation in Mice with Cardiac Expression of Expanded CUG-Repeat mRNA"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amAna Gomez (INSERM, France)
"Diverse Arrhythmogenic Mechanisms in CPVT1"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:20 amMariana Casas (Universidad de Chile, Chile)
"Functional Cross Talk Between the Dihydropyridine Receptor and Pannexin 1 in Skeletal Muscle"
11:20 am - 11:25 amDiscussion
11:25 am - 11:35 amDuilio Potenza (University of Bern, Switzerland)
"Ablation of the RyR2-Ser2030 Phosphorylation Site Limits Changes in RyR2 Sensitivity During β-Adrenergic Stimulation"
11:35 am - 11:40 amDiscussion
11:40 am - 11:50 amTakashi Murayama (Juntendo University School of Medicine, Japan)
"Novel CPVT Mutations in RyR2 with Altered Response to CICR Ligand"
11:50 am - 11:55 amDiscussion
11:55 am - 12:00 pmGeneral Discussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmOngoing Clinical Trials for Myopathies with EC Coupling Alteration
Discussion Leader: Susan Treves (University Hospital of Basel, Switzerland)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmCaroline Le Guiner (UMR 1089, INSERM / University of Nantes, France)
"AAV Vectors as Potential Therapeutics for Duchenne Muscular Dystrophy"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmKaty Meilleur (National Institute of Nursing Research, NIH, USA)
"Update on N-Acetylcysteine Trial in RYR1-Related Myopathy"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:30 pmOmid Haji-Ghassemi (University of British Columbia, Canada)
"Probing the Role of PKA and CaMKII Phosphorylation on the Cardiac Ryanodine Receptor"
7:30 pm - 7:40 pmDiscussion
7:40 pm - 7:50 pmRazvan Cornea (University of Minnesota, USA)
"High-Throughput Screening to Discover Allosteric Inhibitors of Leaky RyR2 for Heart Failure and Arrhythmia Therapy"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFuture Directions for Therapeutic Development
Discussion Leader: Robert Dirksen (University of Rochester Medical Center, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amEric Olson (University of Texas Southwestern Medical Center, USA)
"CRISPR/Cas9 for Muscle Disease"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amCesare Terracciano (Imperial Centre for Translational and Experimental Medicine, United Kingdom)
"Excitation-Contraction Coupling Plasticity in Pluripotent Stem Cell-Derived Cardiac Myocytes"
10:10 am - 10:30 amDiscussion
10:30 am - 11:10 amCoffee Break
11:10 am - 11:25 amMichael Fill (Rush University Medical Center, USA)
"Preventing Ca Evoked Arrhythmias with Ryanodine Receptor Targeted Drugs"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amPrzemyslaw Radwanski (The Ohio State University, USA)
"Enhanced Neuronal Na+ Channel Activity Associated with Arrhythmogenic Calmodulin Mutations"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amJames Dowling (Hospital for Sick Children, Canada)
"Myotubular Myopathy and Excitation Contraction Coupling: From Pathomechanism(s) to Therapy"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmThe Pivotal Role of Mitochondria
Discussion Leader: Shey-Shing Sheu (Thomas Jefferson University, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmBrian O'Rourke (Johns Hopkins University, USA)
"Oxidative Stress and Mitochondria in Cardiomyocytes"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmLivia Hool (University of Western Australia, Australia)
"Determining Efficacy of Therapy to Reverse Duchenne Muscular Dystrophy Cardiomyopathy"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:30 pmW. Jonathan Lederer (University of Maryland School of Medicine, USA)
"Regulation of Metabolism in Individual Mitochondria During E-C Coupling"
7:30 pm - 7:40 pmDiscussion
7:40 pm - 7:50 pmEnrique Jaimovich (Universidad de Chile, Chile)
"Excitation-Metabolism Coupling in Skeletal Muscle"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmThe Accessory Proteins
Discussion Leader: Jianje Ma (Ohio State University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amAlexander Polster (University of Colorado Denver, USA)
"Identifying Proteins Essential for Skeletal-Type EC Coupling Calcium Release"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amFrancesco Zorzato (University of Ferrara, Italy)
"JP45 and CSQ"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amAlicia Mattiazzi (National University of La Plata, Argentina)
"Phospholamban Modification to Rescue Arrhythmias Related to RyR2 Phosphorylation"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:25 amRebecca Sitsapesan (University of Oxford, United Kingdom)
"Role of MG 23 in Skeletal Muscle"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amMarta Campiglio (Medical University of Innsbruck, Austria)
"Chimeric Approach Reveals the Domains of the STAC3/CaV1.1 Interaction"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amVincenzo Sorrentino (University of Siena, Italy)
"Identification and Characterization of Mutations in the CASQ1 Gene in Patients with Tubular Aggregate Myopathy (TAM)"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmKeynote Session: Physiological and Pathophysiological Calcium Entry
Discussion Leader: Bernhard Flucher (Medical University of Innsbruck, Austria)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmSaturo Noguchi (National Institute of Neuroscience, Japan)
"Functional Effect of ORAI1 Mutations in Muscle Diseases"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmSimona Boncompagni ("G. d'Annunzio" University of Chieti-Pescara, Italy)
"Exercise-Dependent Formation of New SR-TT Junctions Which Promotes Increased STIM1-Orai1 Colocalization"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmBeatrix Dienes (University of Debrecen, Hungary)
"Role of Calcium Flux Through DHPR"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmClara Franzini-Armstrong (University of Pennsylvania, USA)
"What Structure Tells You if You Look"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13AR071770-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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