Gordon Research Conferences
Meeting Details
Search:
  GO

Natural Products & Bioactive Compounds
Gordon Research Conference

Exploring the Therapeutic Potential of Natural Products and Biologically Active Compounds Through Chemical and Biological Technologies

Dates

July 31 - August 5, 2016

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Richard E. Taylor

Vice Chair:
Steven J. Wittenberger

Meeting Description

Throughout history, natural products have been an inspiration to researchers from many fields. Their complex structures have stimulated investigations into the biosynthetic pathways and provided a motivation to identify new chemical reactions and synthetic strategies enabling their preparation. Their ability to modulate biological pathways have been identified through chemical ecology studies designed to understand the evolutionary advantage they provide their producing organism and the search for next generation chemotherapeutic agents for human disease. The field continues to evolve as technological advances enable identification and characterization of minute chemical components from complex mixtures, the fermentation of previously unculturable microorganisms, and the genetic manipulation of natural product producers.

The 65th Gordon Research Conference on Natural Products in 2016 will feature outstanding lectures featuring research and researchers that explore the therapeutic potential of natural products through the development of chemical and biological technologies. The lectures are meant to highlight unpublished research and stimulate discussion. Complementary informal research presentations will occur through the use of poster sessions. The GRC on Natural Products also provides significant opportunity for professional and social interactions between conference attendees.

Like previous years, the meeting will be held at the Proctor Academy in Andover, New Hampshire. The site offers outstanding staff and a relaxed setting that is ideally suited for both the scientific, social, recreational aspects of the Gordon Conferences.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmSynthesis Enabled Biological Studies
Discussion Leader: Joanne Harvey (Victoria University of Wellington, New Zealand)
7:40 pm - 8:10 pmEmmanuel Theodorakis (University of California, San Diego, USA)
"Natural Products: From Flask to Cell"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmCorinna Schindler (University of Michigan, USA)
"New Carbocyclization Reactions for the Synthesis of Complex Molecules"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmArmen Zakarian (University of California, Santa Barbara, USA)
"Recent Advances in Natural Products Synthesis and Biological Studies"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTechnology Driven Chemical Synthesis
Discussion Leader: Arun Thottumkara (Revolution Medicines, USA)
9:00 am - 9:30 amTimothy Jamison (Massachusetts Institute of Technology, USA)
"Continuous Flow Multistep Synthesis"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amAlexander Godfrey (Eli Lilly & Co., USA)
"Automated Synthesis: An Invitation to the Lab of the Future"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:10 amPeter Seeberger (Max Planck Institute of Colloids and Interfaces, Germany)
"From Automated Glycan Assembly to Synthetic Vaccines Against Infectious Diseases"
11:10 am - 11:20 amDiscussion
11:20 am - 11:50 amIan Davies (Merck Research Laboratories, USA)
"Big Data and Its Impact on the Synthetic Chemistry Skillset"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Michelle Garnsey (Pfizer, Inc., USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAntibiotic Discovery
Discussion Leader: Marcy Balunas (University of Connecticut, USA)
7:30 pm - 8:00 pmChristian Melander (North Carolina State University, USA)
"Adjunctive Approaches to Break Antibiotic Resistance"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmStefan Koenig (Genentech, Inc., USA)
"Arming S. aureus-Targeting Antibody-Antibiotic Conjugates (AACs) Through Process Chemistry"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmElizabeth Nolan (Massachusetts Institute of Technology, USA)
"Siderophores, Antibiotics and the Microbiota"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNext Generation Drug Discovery
Discussion Leader: Leslie Aldrich (University of Illinois at Chicago, USA)
9:00 am - 9:25 amPaul Fatheree (Theravance, USA)
"The Chemistry and Preclinical Biology of Novel Polymyxin Antibacterials for the Treatment of Gram Negative Infections"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amDenise Barrault (National Phenotypic Screening Centre, United Kingdom)
"Public-Private Partnerships that Drive Innovation in Drug Discovery"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:10 amStephen Frye (University of North Carolina at Chapel Hill, USA)
"Chemical Biology of Methyl Lysine"
11:10 am - 11:20 amDiscussion
11:20 am - 11:50 amHendrik Luesch (University of Florida, USA)
"Multilevel Characterization of Natural Products from Marine Cyanobacteria"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChemistry of the Human Microbiome
Discussion Leader: Sean Davies (Vanderbilt University, USA)
7:30 pm - 8:00 pmMichael Fischbach (University of California, San Francisco, USA)
"Small Molecules from the Human Microbiota"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmEmily Balskus (Harvard University, USA)
"Gut Reactions: Chemical Discovery and the Human Microbiota"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmPieter Dorrestein (University of California, San Diego, USA)
"Global Natural Products Social Molecular Networking in Space and Time"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStrategies and Tactics for Chemical Synthesis
Discussion Leader: Joshua Pierce (North Carolina State University, USA)
9:00 am - 9:30 amPatrick Harran (University of California, Los Angeles, USA)
"Crafting Macrocycles with Designed Scaffolding"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amRendy Kartika (Louisiana State University, USA)
"New Chemistries with Oxyallyl Cations"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:10 amPaul Floreancig (University of Pittsburgh, USA)
"Transposition Reactions for Increasing Molecular Complexity"
11:10 am - 11:20 amDiscussion
11:20 am - 11:50 amToshiaki Sunazuka (The Kitasato Institute, Kitasato University, Japan)
"Synthetic Strategy for Construction of Unique Polycyclic Natural Products"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmBiosynthesis-Inspired Technologies
Discussion Leader: Wendy Kelly (Georgia Institute of Technology, USA)
7:30 pm - 8:00 pmAdrian Keatinge-Clay (University of Texas at Austin, USA)
"Visualizing and Harnessing Polyketide Assembly Lines"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMichael Burkart (University of California, San Diego, USA)
"Directing Natural Product Biosynthesis in the Acetate Pathway"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmMichelle Chang (University of California, Berkeley, USA)
"Synthetic Biology Approaches to New Fluorine Chemistry"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDrug Discovery Platforms for Cancer and Rare Diseases
Discussion Leader: Michelle Garnsey (Pfizer, Inc., USA)
9:00 am - 9:30 amAndres Francesch (Pharmamar, Spain)
"Discovery and Development of Marine Anticancer Drugs"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amRoger Linington (Simon Fraser University, Canada)
"Towards Universal Compound Discovery: Applications of the Natural Products Atlas"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:05 amSelected from Poster Abstracts: Alexander Grenning (University of Florida, USA)
"A Tunable Terpenoid Synthesis Strategy"
11:05 am - 11:10 amDiscussion
11:10 am - 11:40 amQiu Wang (Duke University, USA)
"Leveraging Chemistry for Biology and Therapy: New Amination Strategies to Access Biologically Important Molecules"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmMark O'Neil-Johnson (Sequoia Sciences, Inc., USA)
"Has Combinatorial Chemistry Hurt Us All?"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: State-of-the-Art Chemistry and Biology
Discussion Leader: Jon Rainier (University of Utah, USA)
7:30 pm - 8:00 pmGabriela Chiosis (Memorial Sloan Kettering Cancer Center, USA)
"The Chaperome as a Target in Cancer"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmStephen Moss (Isomerase Therapeutics, United Kingdom)
"Natural Product Drug Discovery Through Biosynthetic Engineering"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmThomas Hoye (University of Minnesota, USA)
"Natural Product vis-à-vis Benzyne Chemistry"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA206198-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter