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Natural Products & Bioactive Compounds
Gordon Research Conference

Natural Products: A Nexus for Chemical and Biological Research to Discover and Understand the Potential of Novel Bioactive Compounds on Human Health

Dates

July 30 - August 4, 2017

Location

Proctor Academy
Andover, NH Site Information

Organizers

Chair:
Steven J. Wittenberger

Vice Chair:
Christopher N. Boddy

Application Deadline

Applications for this meeting must be submitted by July 2, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

Beginning with ancient traditional medicines, natural products have inspired study. Contemporary research invites collaboration across disciplines of biology, chemistry and engineering. We study the biosynthetic pathways and modes of action of these bioactive compounds, we are inspired by their complex architecture and we are motivated to test new synthetic strategies and invent chemical reactions to enable their preparation. Returning full circle, natural products research is a platform that allows us to achieve our ultimate objective of improving human health.

The 66th Gordon Research Conference on Natural Products and Bioactive Compounds features lectures describing state-of-the-art research by leaders in the fields of organic synthesis, chemical biology, rare and neglected disease research, glycochemistry, natural product isolation and biosynthesis. These presentations are intended to highlight unpublished research and stimulate discussion. In addition, several highly interactive poster sessions provide the means and opportunity for conference participants to share and discuss their own work in a comfortable and informal setting. Finally, the GRC format allows for professional and social interactions for all conference attendees.

The GRC on Natural Products and Bioactive Compounds will be held at the Proctor Academy in Andover, New Hampshire. Having hosted the conference for several years, this site has an outstanding staff and offers a picturesque and relaxed setting which is ideally suited to this conference and its scientific and social nature.

Related Meeting

This GRC will be held in conjunction with the "Natural Products & Bioactive Compounds" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNovel Catalytic Strategies
Discussion Leader: Elaine Lee (Vertex Pharmaceuticals, USA)
7:40 pm - 8:05 pmNick Desrosiers (Boehringer-Ingelheim, USA)
"Development of Novel Non-Precious Metal Catalyzed Methodologies for the Synthesis of Biologically Active Heterocyclic Compounds"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmKami Hull (University of Illinois at Urbana-Champaign, USA)
"Transition Metal-Catalyzed Amination and Amidation Reactions"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmEric Jacobsen (Harvard University, USA)
"Stereoselective Catalysis of Nucleophilic Substitution Reactions"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDiscovery of Novel Natural Products
Discussion Leader: Mariya Kozytska (Mersana Therapeutics, USA)
9:00 am - 9:30 amMohammad Seyedsayamdost (Princeton University, USA)
"New Approaches for the Discovery of Microbial Natural Products"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amWenjun Zhang (University of California, Berkeley, USA)
"Discovery of Novel Bioactive Polyketides/Non-Ribosomal Peptides from Microbes"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:10 amDaniel Gray (Warp Drive Bio, Inc., USA)
"Harnessing Genomic Information to Engineer the Biosynthesis of Natural Products"
11:10 am - 11:20 amDiscussion
11:20 am - 11:50 amSean Brady (Rockefeller University, USA)
"Culture Independent Approaches for the Discovery of New Bacterial Metabolites"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Elizabeth Swift (AbbVie, USA) and Sarah Reisman (California Institute of Technology, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInnovations in Drug Discovery
Discussion Leader: Matthew Lamarche (Novartis, USA)
7:30 pm - 8:00 pmSiegfried Reich (eFFECTOR Therapeutics, USA)
"Correcting Disregulated Translation: Disciplined Structure-Based Inhibitor Design of eFT508 for the Treatment of Cancer"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmCheryl Hayward (Pfizer, USA)
"Scaling Highly Potent Bifunctional Duocarmycin Derivatives for Treatment of Cancer"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmSamarjit Patnaik (National Center for Advancing Translational Sciences, NIH, USA)
"Bioactivity and Mechanism of Action of N-Docosahexaenoylethanolamine Derivatives in Neuronal Development"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNatural Products Biosynthesis
Discussion Leader: Ryan Phelan (AbbVie, USA)
9:00 am - 9:30 amElizabeth Sattley (Stanford University, USA)
"Discovery and Engineering of Plant Chemistry"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amAmy Lane (University of North Florida, USA)
"Harnessing the Biosynthetic Capabilities of Marine Actinomycetes"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:10 amAnne Osbourn (John Innes Centre, United Kingdom)
"Harnessing Plant Metabolic Diversity"
11:10 am - 11:20 amDiscussion
11:20 am - 11:50 amJay Keasling (University of California, Berkeley, USA)
"Engineered Polyketide Synthases for Production of Commodity and Specialty Chemicals"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Chemistry, Structure and Function of Complex Glycosides
Discussion Leader: Matthew Shoulders (Massachusetts Institute of Technology, USA)
7:30 pm - 8:00 pmJennifer Kohler (University of Texas Southwestern Medical Center, USA)
"New Chemical Biology Methods to Uncover the Functional Roles of Glycosylation"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmLai-Xi Wang (University of Maryland, College Park, USA)
"Chemoenzymatic Synthesis of Glycoproteins for Probing Functions"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmLaura Kiessling (University of Wisconsin-Madison, USA)
"Chemistry to Explore and Exploit Microbial Carbohydrates for Health and Disease"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStructurally Complex Natural Products Synthesis
Discussion Leader: Cedric Hugelshofer (University of California, Berkeley, USA)
9:00 am - 9:30 amThomas Maimone (University of California, Berkeley, USA)
"Synthesis of Complex Terpenes from Simple Precursors"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amRyan Shenvi (Scripps Research Institute, USA)
"Chemical Synthesis of Secondary Metabolites"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:10 amAng Li (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China)
"Total Synthesis of Polycyclic Natural Products"
11:10 am - 11:20 amDiscussion
11:20 am - 11:50 amSarah Reisman (California Institute of Technology, USA)
"Building Bridges: Strategies for the Synthesis of Complex Polycyclic Natural Products"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmRare and Neglected Disease Research
Discussion Leader: Thomas Von Geldern (Embedded Consulting, USA)
7:30 pm - 8:00 pmBenjamin Perry (Drugs for Neglected Diseases Initiative, Switzerland)
"Collaborative Virtual Screening to Boost Neglected Tropical Disease Drug Discovery"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJidong Zhang (Sanofi, France)
"Discovery of Sequanamycin Derivatives as Potent Oral Anti-Tuberculosis Agents"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmClifton Barry (Tuberculosis Research Units, National Institute of Allergy and Infectious Diseases, NIH, USA)
"Bogged Down: An Ecology-Inspired Search for Novel Antituberculars"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew Approaches to the Study of Bioactive Natural Products
Discussion Leader: Michael Luzzio (USA)
9:00 am - 9:30 amErin Carlson (University of Minnesota, USA)
"Exploring the Master Regulators of Microbial Behavior"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amJoshua Pierce (North Carolina State University, USA)
"Marine Natural Products Synthesis: A Driving Force for Chemical and Biological Discovery"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:00 amShort Talk Selected from Poster Abstracts
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amGuangxin Liang (Nankai University, China)
"Syntheses Through 'Seeding and Growing' Strategy Inspired by Molecular Pattern Recognition"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmKarl Scheidt (Northwestern University, USA)
"Leveraging Carbene Catalysis for Complex Synthesis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStrategies and Tactics for Chemical Synthesis
Discussion Leader: Elizabeth Swift (AbbVie, USA)
7:30 pm - 7:50 pmTodd Hyster (Princeton University, USA)
"Unlocking Catalytic Promiscuity with Light: Non-Natural Free Radical Chemistry Within a Protein Active Site"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:30 pmKevin Moeller (Washington University, USA)
"From Radical Cations to Microelectrode Arrays to the Valorization of Lignin: Using Principles in Physical Organic Chemistry to Guide Electrochemical Solutions to Modern Synthetic Challenges"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmAlexander M. Cruickshank Lecture: David MacMillan (Princeton University, USA)
"New Photoredox Reactions"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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