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Organic Reactions & Processes
Gordon Research Conference

Catalysis and Mechanism: Enabling Efficiency in Synthesis

Dates

July 23-28, 2017

Location

Stonehill College
Easton, MA Site Information

Organizers

Chairs:
Silas Cook & Travis P. Remarchuk

Vice Chairs:
Jeremy A. May & Jennifer Albaneze-Walker

Application Deadline

Applications for this meeting must be submitted by June 25, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2017 Gordon Research Conference (GRC) on Organic Reactions and Processes will celebrate its 63rd consecutive annual gathering of the foremost experts in the art of bond formation. This GRC conference attracts a diverse group of scientists from both industry and academia who seek to unravel the latest trends in modern organic chemistry to create unique molecular architectures.

The 2017 meeting will feature invited lectures that span recent fundamental discoveries to large-scale implementation of modern methods. The program will feature speakers that are both well-established and emerging young scientists from academia and industry across several continents. Each session will offer important chemical insights into current problems relevant to both students and seasoned scientists. Topics include the latest in industrial process chemistry, total synthesis, chemical biology, catalysis, methodology development and reaction mechanism. By bringing together diverse scientists to discuss the latest trends and unpublished results in pre-competitive space, the conference promotes the rapid adoption of the latest insights by both academic and industrial practitioners. The lively discussions directly impact our current understanding of chemistry while simultaneously sowing the seeds for critical collaborations among attendees.

In addition to the exciting lineup of speakers, this conference also features outstanding and highly energetic poster sessions. Thus, attendees are strongly encouraged to submit a poster abstract at the time of their applications. A subset of the posters will be selected to present oral "short talks" on Thursday morning, providing an outstanding opportunity to share your research with leaders in the field.

This conference becomes heavily oversubscribed, so we encourage early application. The deadline for submitting poster abstracts is June 25th, 2017, four weeks before the conference begins.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNew Reaction Methodology
Discussion Leader: Donna Blackmond (Scripps Research Institute, USA)
7:40 pm - 8:10 pmSimon Meek (University of North Carolina at Chapel Hill, USA)
"Reaction Mechanisms that Lead to Enantioselective Transformations"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:45 pmFranziska Schoenebeck (RWTH Aachen University, Germany)
"Adventures in Catalysis: From Mechanisms to Applications"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmGregory Fu (California Institute of Technology, USA)
"Metal-Catalyzed Coupling Reactions of Alkyl Electrophiles"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEfficient Processes in Drug Development
Discussion Leaders: Nicole Goodwin (GlaxoSmithKline, USA) and Richard Pariza (Neuralstem, Inc., USA)
9:00 am - 9:30 amLouis-Charles Campeau (Merck & Co., Inc., USA)
"Adventures in Selective Phosphorylation and Other Reactions You Didn't Know Were Difficult"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amBob Dugger (Pfizer Inc., USA)
"Process Development of Lorlatinib"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amLate-Breaking Topic
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmLauren Sirois (Genentech, USA)
"Process Development for the Multi-Kilogram-Scale Synthesis of an Active Pharmaceutical Ingredient"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Pamela Tadross (Merck & Co., Inc., USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPrecious Metal Catalysis
Discussion Leader: Robert Maleczka (Michigan State University, USA)
7:30 pm - 8:00 pmJohn Hartwig (University of California, Berkeley, USA)
"Site-Selective Functionalization with Small and Large Catalysts"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmLate-Breaking Topic
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmJin-Quan Yu (The Scripps Research Institute, USA)
"Enantioselective and Remote C-H Activation Through Metal Insertions"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew Reaction Technologies
Discussion Leaders: Ming-Yu Ngai (State University of New York at Stony Brook, USA) and William Trenkle (U.S. Office of Research Integrity, HHS, USA)
9:00 am - 9:30 amMarisa Kozlowski (University of Pennsylvania, USA)
"New Approaches to Reaction Development"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amYongda Zhang (Boehringer Ingelheim Pharmaceuticals, Inc., USA)
"Asymmetric and Catalytic Transformation for BI Drug Development"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amShashank Shekhar (AbbVie, USA)
"Evolution of a Process to Synthesize ABT-333, an HCV Polymerase Inhibitor"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmChristopher Uyeda (Purdue University, USA)
"Catalytic Reactions at Metal-Metal Bonds"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStudies of Reaction Mechanism
Discussion Leader: Thomas Snaddon (Indiana University, USA)
7:30 pm - 8:00 pmDean Tantillo (University of California, Davis, USA)
"Turning Computational Complications into Opportunities for Reaction Optimization and Design"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDeryn Fogg (University of Ottawa, Canada)
"Ex Detritus, Scientia: Decomposition Pathways in Olefin Metathesis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmDavid Collum (Cornell University, USA)
"Structure-Reactivity-Selectivity Relationships in Alkali Metal Enolates"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynthesis of Bioactive Compounds
Discussion Leaders: Catharine Larsen (University of California, Riverside, USA) and Neal Anderson (Anderson's Process Solutions LLC, USA)
9:00 am - 9:30 amMikiko Sodeoka (RIKEN, Japan)
"New Approaches to Bioactive Molecules"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amLate-Breaking Topic
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amNoah Burns (Stanford University, USA)
"Selective Synthesis of Unusual Lipids"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmDirk Trauner (New York University, USA / University of Munich, Germany)
"Complexity from Cascades"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmAdvances in Asymmetric Methods in Chemical Synthesis
Discussion Leader: Marisa Kozlowski (University of Pennsylvania, USA)
7:30 pm - 8:00 pmT V Babu Rajanbabu (Ohio State University, USA)
"Catalytic Enantioselective Vinylation Reactions of Alkenes"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmClement Mazet (University of Geneva, Switzerland)
"Insights into the Mechanism of Carbofunctionalizations of Dihydrofurans"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmErick Carreira (ETH Zurich, Switzerland)
"New Insights in Catalysis"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDevelopment Strategies in Process Research
Discussion Leaders: Kevin Brown (Indiana University, USA) and Jean Suffert (CNRS, France)
9:00 am - 9:30 amStefan Abele (Actelion Pharmaceuticals Ltd., Switzerland)
"Development of the Manufacturing Route to Cenerimod – An S1P Receptor 1 Agonist"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amEric Simmons (Bristol-Myers Squibb, USA)
"Process Development and Application of a Pd-Catalyzed Direct Arylation in the Commercial Synthesis of the HCV NS5B Inhibitor Beclabuvir"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amDonna Blackmond (Scripps Research Institute, USA)
"Pd-Catalyzed C-H Functionalizations: A Chameleon Changes Color"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: The Awesome Power of Organic Synthesis
Discussion Leaders: Jeremy May (University of Houston, USA) and Jennifer Albaneze-Walker (Johnson and Johnson, Belgium)
7:30 pm - 8:00 pmThomas Hoye (University of Minnesota, USA)
"What's New with the Hexadehydro-Diels-Alder (HDDA) Reaction?"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmHuw Davies (Emory University, USA)
"Catalyst-Controlled C-H Functionalization"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmRonald Breslow (Columbia University, USA)
"Prebiotic Chemistry Leading Toward Life"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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