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Oxygen Radicals
Gordon Research Conference

Oxygen Radicals as Effectors of Redox Biology

Dates

February 7-12, 2016

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chairs:
Rakesh P. Patel & Ana Denicola

Vice Chairs:
Douglas D. Thomas & Michael Davies

Meeting Description

The 2016 Oxygen Radicals Gordon Research Conference will present and discuss the most up-to-date research on oxygen radicals as effectors of redox biology. The program is designed to have broad appeal to all scientists and clinicians with an interest in oxygen radicals, encompassing several areas including mechanisms of action, roles in disease, new detection techniques, and emerging concepts related to cross-talk with other redox signaling effectors (e.g. H2S, CO). Specific sessions will be Pathophysiologic roles of oxidized lipids, Sirtuins aging and redox, Emerging paradigms in redox signaling, New detection methods and probes, Oxygen radicals and mechanisms of disease, Infectious diseases and free radicals, Role for CO and H2S in oxygen radicals biology. Cutting-edge presentations will be delivered by 32 speakers that represent current and future leaders in free radical biology and medicine, with an additional 7 slots to be filled from selected abstracts. The meeting will also begin and end with keynote lectures from Professors Gregg Semenza and Michael Murphy, pioneers in the areas of HIF-signaling and mitochondrial reactive species respectively. Two separate poster sessions are also scheduled and overall the conference is organized so that ample opportunities for discussion are provided, and importantly interactions between senior and junior scientists, and trainees is fostered in a collegial setting. Furthermore, and based on the success of the inaugural Oxygen radicals GRS that partnered with the 2014 Oxygen Radicals GRC meeting, we are pleased that the 2016 Oxygen Radicals GRC will be preceded by a 2-day GRS meeting that is organized and run solely by trainees (Divya Vasudevan (USA) and Daniel Ferguson (UK)) and anticipate that this will further enhance the quality of cutting-edge science presented and discussed at the meeting as well as providing unique networking and career development opportunities.

Related Meeting

This GRC was held in conjunction with the "Oxygen Radicals" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Sleep Apnea, Oxygen Radicals and Hypertension
Discussion Leader: Rakesh Patel (University of Alabama at Birmingham, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:40 pmGregg Semenza (Johns Hopkins University, USA)
"Sleep Apnea, Oxygen Radicals and Hypertension"
8:40 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPathophysiologic Roles of Oxidized Lipids
Discussion Leaders: Henry Jay Forman (University of Southern California, USA) and Homero Rubbo (University of the Republic, Uruguay)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amBruce Freeman (University of Pittsburgh, USA)
"Anti-Inflammatory Electrophilic Fatty Acid Species"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amDavid Ford (Saint Louis University School of Medicine, USA)
"Chlorinated Fatty Acids and ROS"
9:55 am - 10:05 amDiscussion
10:05 am - 10:25 amAnna-Liisa Levonen (University of Eastern Finland, Finland)
"Activation of Stress Signaling Pathways by Electrophilic Lipids"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amValerie O'Donnell (Cardiff University, United Kingdom)
"Mapping the Platelet Oxy-Lipidome"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amChris Cooper (University of Essex, United Kingdom)
"Artificial Blood: Engineering a Haemoglobin Based Oxygen Carrier with Decreased Lipid Peroxidation Activity"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: Witold Korytowski (Medical College of Wisconsin, USA)
"Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking; Implications for Atherogemesis Under Oxidative Stress"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Manisha Patel (University of Colorado, Anschutz Medical Campus, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSirtuins, Aging and Redox
Discussion Leaders: Rick Domann (University of Iowa, USA) and Sruti Shiva (University of Pittsburgh, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:45 pmSelected from Poster Abstracts: Lindsey Gano (University of Colorado Anschutz Medical Campus, USA)
"SIRT3 Dysfunction in Experimental Temporal Lobe Epilepsy"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:10 pmRaul Mostoslavsky (Massachusetts General Hospital, Harvard Medical School, USA)
"Sirtuins in Regulation of Redox Status"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmCarlos Escande (Institut Pasteur de Montevideo, Uruguay)
"Role of the Protein DBC1 in the Regulation of Obesity and Aging"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmPaul Brookes (University of Rochester Medical Center, USA)
"Sirtuins and Mitochondrial Redox"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEmerging Paradigms in Redox Signaling
Discussion Leaders: Victor Darley-Usmar (University of Alabama at Birmingham, USA) and Douglas Thomas (University of Illinois at Chicago, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amRaj Soorappan (University of Alabama at Birmingham, USA)
"Reductive Stress and Proteotoxicity"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amTobias Dick (German Cancer Research Center, Germany)
"Thiol Peroxidase Based Redox Relays"
9:55 am - 10:05 amDiscussion
10:05 am - 10:25 amYvonne Hanssen Heininger (University of Vermont, USA)
"Glutaredoxin and S-Glutathionylation Dependent Redox Signaling"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amDaniela Salvemini (St. Louis University, USA)
"Free Radicals and Pain Sensing"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amJoris Messens (VIB, Vrije Universiteit Brussel, Belgium)
"Promiscuity in Thiol Redox Control"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: Shireen Attaran (University of Pittsburgh, USA)
"Prdx1 Inhibits Breast Cancer Progression Through Inhibiting the Activated Phenotype of Mammary Stroma-Associated Fibroblasts"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew Detection Methods and Probes for Reactive Species
Discussion Leaders: Paul Winyard (University of Exeter Medical School, United Kingdom) and Jacek Zielonka (Medical College of Wisconsin, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmVinayak Gupta (The Scripps Research Institute - Florida, USA)
"Tag-Switch Methods for Thiols and Sulfide Measurement"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmDan Yang (The University of Hong Kong, Hong Kong SAR China)
"Fluorescent Probe Based Detection of Free Radicals in Biological Systems"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmCristina Furdui (Wake Forest School of Medicine, USA)
"Chemical Approaches to Investigate Thiol-Based Redox Regulation in Biological Systems"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmAshutosh Kumar (National Institute of Environmental Health Sciences, NIH, USA)
"Immuno-Spin Trapping of Alpha-Synuclein Radical Formed in Maneb and Paraquat Induced Model of Parkinson's Disease"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOxygen Radicals and Mechanisms of Disease
Discussion Leader: Victor Thannickal (University of Alabama at Birmingham, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amKaren Bernard (University of Alabama at Birmingham, USA)
"Mitochondrial ROS and Lung Fibrosis"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amCarola Neumann (Magee-Womens Research Institute, USA)
"The Role of Prx-1 in Cancer Signaling"
9:55 am - 10:05 amDiscussion
10:05 am - 10:25 amFrancisco Laurindo (Heart Institute of the University of São Paulo, Brazil)
"Pathophysiology of NOX in Cardiovascular Disease"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amDouglas Spitz (University of Iowa, USA)
"ROS and Cancer"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amManisha Patel (University of Colorado, Anschutz Medical Campus, USA)
"Mitochondrial ROS and Neuronal Disorders"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: Clare Hawkins (Heart Research Institute, Australia)
"Role of the Myeloperoxidase Oxidant Hypothiocyanous Acid (HOSCN) in Redox Perturbation and Cellular Dysfunction"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmInfectious Diseases and Free Radicals
Discussion Leaders: Michael Davies (University of Copenhagen, Denmark) and Christine Winterbourn (University of Otago Christchurch, New Zealand)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:45 pmSelected from Poster Abstracts: Lin Mantell (North Shore University Hospital, St. John's University, USA)
"The α7 Nicotinic Acetylcholine Receptor Agonist GTS-21 Improves Bacterial Clearance by Restoring Hyperoxia-Compromised Macrophage Function"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:10 pmJon Lundberg (Karolinska Institutet, Sweden)
"Gut Microbiota and Nitrogen Oxide Signaling"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmMichelle Reniere (University of Washington, USA)
"Glutathione and Pathogen Virulence"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmLars Dietrich (Columbia University, USA)
"Redox Regulation of Biofilm Development in Pseudomonas aeruginosa"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRole for CO and H2S in Oxygen Radicals Biology
Discussion Leaders: Neil Hogg (Medical College of Wisconsin, USA) and Jon Lundberg (Karolinska Institutet, Sweden)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amBeatriz Alvarez (University of the Republic, Uruguay)
"Reactivity of Hydrogen Sulfide with Oxidants"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amWayne Orr (LSU Health Sciences Center Shreveport, USA)
"H2S and ROS Signaling"
9:55 am - 10:05 amDiscussion
10:05 am - 10:25 amTakaaki Akaike (Tohoku University Graduate School of Medicine, Japan)
"Polysulfides and Redox Signaling"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amRoland Stocker (Victor Chang Cardiac Research Institute, Australia)
"Novel Insights into Tryptophan Oxidation Mediated by Indoleamine 2,3-Dioxygenase and Its Role in Arterial Relaxation"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amRoberto Motterlini (INSERM U955 / Université Paris-Est, France)
"CO-Releasing Molecules and Redox Signaling"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: Bindu Paul (Johns Hopkins University School of Medicine, USA)
"The Intersection Between H2S and Superoxide Signaling in Amyotrophic Lateral Sclerosis"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Mitochondrially Targeted Antioxidants and Signaling
Discussion Leader: Ana Denicola (University of the Republic, Uruguay)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:30 pmMichael Murphy (MRC Mitochondrial Biology Unit, United Kingdom)
"Mitochondrially Targeted Antioxidants and Signaling"
8:30 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmGeneral Discussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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