Gordon Research Conferences
Meeting Details
Search:
  GO

Host-Parasite Interactions, Biology of
Gordon Research Conference

Molecular and Translational Advances in Parasitic Diseases

Dates

June 12-17, 2016

Location

Salve Regina University
Newport, RI

Organizers

Chairs:
Kasturi Haldar & Malcolm J. McConville

Vice Chairs:
Meg Phillips & Luisa M. Figueiredo

Meeting Description

The 2016 GRC on the Biology of Host-Parasite Interactions is focused on new molecular and translational advances in parasitic diseases. The conference will place special emphasis on the interdisciplinary approaches needed for new discoveries as well as effective therapeutic strategies to control a wide range of human and veterinarian pathogens that cause malaria, toxoplasmosis, trypanosomiasis, leishmaniasis, amoebiasis and worm infections. The program will feature a wide range of topics including pharma programs of drug discovery and development in parasitic diseases, rapid advance of new therapies to treat human disease and block transmission, the challenges of drug resistance, lipid and protein signaling mechanisms, additional new targets in entry, intracellular development, differentiation and transmission and the latest in molecular, biochemical and genetic tools that empower new molecular and translational paradigms of therapy.

The aim of the meeting is to bring together scientists from all over the globe (with special emphasis on young scientists from endemic areas) to share and synthesize knowledge to drive future control and elimination research agendas. This GRC conference and its associated GRS offer unique opportunity early career scientists and graduate students to lead amongst their peers and exchange ideas at the forefront of research in a serene but stimulating atmosphere at the Salve Regina University Campus, Newport. Short talks will be selected from submitted abstracts reporting latest ground-breaking findings. Students, post-docs and early career scientists are strongly encouraged to apply to the GRC and GRS. Special efforts are being made to raise funds to provide individuals from endemic countries with support.

Related Meeting

This GRC was held in conjunction with the "Host-Parasite Interactions, Biology of" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmPharma Partnerships in Parasitic Diseases
Discussion Leader: Meg Phillips (University of Texas Southwestern Medical Center, USA)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmJeremy Burrows (Medicines for Malaria Venture, Switzerland)
"The Eradication Challenge: Discovering Next Generation Antimalarials"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmThierry Diagana (Novartis Institute for Tropical Diseases, Singapore)
"Addressing Unmet Medical Need of the Developing World Through Collaborative Innovation"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmJulio Martin (GlaxoSmithKline, Spain)
"Discovery in Partnership at GSK: Molecules and Models to Combat Kinetoplastid Diseases"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAdvancing New Therapies to Block Disease and Transmission
Discussion Leader: Kasturi Haldar (University of Notre Dame, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amMeg Phillips (University of Texas Southwestern Medical Center, USA)
"Targeting Malaria Dihydroorotate Dehydrogenase"
9:30 am - 9:40 amDiscussion
9:40 am - 10:15 amCoffee Break
10:15 am - 10:35 amIan Gilbert (University of Dundee, United Kingdom)
"Novel Chemotherapy Against Malaria and Trypanosomes"
10:35 am - 10:45 amDiscussion
10:45 am - 11:05 amElizabeth Winzeler (University of California, San Diego, USA)
"Neglected Diseases Research at the Interface of Chemistry and Genetics"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amErika Flannery (Center for Infectious Disease Research, USA)
"Testing Prophylactic and Radical Cure Activity of Drugs Against Liver-Stage Plasmodium vivax and Plasmodium falciparum in a Humanized Mouse Model"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amAmitabha Mukhopadhyay (National Institute of Immunology, India)
"Hemoglobin Receptor: A Novel Vaccine Candidate for Visceral Leishmaniasis"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amJoey Verdi (Hunter College, City University of New York, USA)
"Germline Transmission of Targeted Baboon Apolipoprotein L-I in Mice Protects Against African Trypanosomes"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmAkhil Vaidya (Drexel University College of Medicine, USA)
"Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in Cholesterol Content and Morphology of Plasmodium falciparum"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenomic/Genetic Regulation and Manipulation
Discussion Leader: David Sibley (Washington University in St. Louis, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmBoris Striepen (University of Georgia, USA)
"Genetic Analysis of the Diarrheal Pathogen Cryptosporidium"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmDavid Fidock (Columbia University, USA)
"Recent Insights Into the Genetic Basis of Antimalarial Drug Resistance"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmJames Collins (University of Texas Southwestern Medical Center, USA)
"Functional Genomic Interrogation of Schistosome Stem Cells"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmYenYu Yang (College of Medicine, National Taiwan University, Taiwan)
"Iron-Inducible Histone Modifications in Trichomonas vaginalis"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmJosh Beck (Washington University School of Medicine in St. Louis, USA)
"Interrogating PTEX Function in P. falciparum Protein Export with Emerging Functional Genetic Approaches"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEmerging Drug Resistance
Discussion Leader: Jeremy Burrows (Medicines for Malaria Venture, Switzerland)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amKasturi Haldar (University of Notre Dame, USA)
"A Molecular Mechanism of Artemisinin Resistance in P. falciparum Malaria"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amArjen Dondorp (Mahidol Oxford Tropical Medicine Research Unit, Thailand)
"The Subclinical Reservoir of Infection"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amCoffee Break
10:30 am - 10:50 amLeann Tilley (University of Melbourne, Australia)
"Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amAbdoulaye Djimde (University of Science, Techniques and Technologies of Bamako, Mali)
"Molecular Determinants of P. falciparum Resistance to Artemisinins and Partenaire Drugs in Sub-Saharan Africa"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amGustavo Afanador (University of Texas Southwestern Medical Center, USA)
"Functional Studies of Trypanosomatid Deoxyhypusine Synthase as Drug Target"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amMarcus Lee (Wellcome Trust Sanger Institute, United Kingdom)
"New Genetic Approaches to Accelerate Antimalarial Target Identification and Validation"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmMiguel Morales (University of Notre Dame, USA)
"Mechanisms of Miltefosine Resistance in Leishmania"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJudith Straimer (Columbia University, USA)
"Impact of K13 Mutations on Parasite Fitness and Susceptibility to Ozonides"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSensing and Signaling in Parasitism
Discussion Leader: Matthias Marti (Harvard T.H. Chan School of Public Health, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmMartin Olivier (McGill University, Canada)
"Nanobiome of Leishmanial Sand Fly Vector: Impact on Leishmaniasis Development"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmKenneth Stuart (Center for Infectious Disease Research, USA)
"Drug Target Systems of Kinetoplastid"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmAlok Bhattacharya (Jawaharlal Nehru University, India)
"Mechanism of Phagocytosis in Entamoeba histolytica"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmCrystal Cooper (University of Western Australia, Australia)
"Host-Parasite Interactions Between Australian Marsupials and Trypanosoma spp."
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmJulia Romano (Johns Hopkins University Bloomberg School of Public Health, USA)
"Unraveling the Process of Nutrient Acquisition by Toxoplasma gondii"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBiochemistry and Metabolism
Discussion Leader: Malcolm McConville (University of Melbourne, Australia)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amDaniel Goldberg (Washington University School of Medicine in St. Louis, USA)
"Plasmodium Effector Proteins"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amMichael Barrett (University of Glasgow, United Kingdom)
"Polyomic Approaches to Understanding Anti-Parasitic Drug Resistance"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amCoffee Break
10:30 am - 10:50 amDomique Soldati (University of Geneva Medical School, Switzerland)
"Aspartiyl Proteases and Establishment of Parasitisim: Revisiting Old Drug Targets"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amAudrey Odom (Washington University School of Medicine in St. Louis, USA)
"The Smell of Success: Volatile Compounds in Malaria"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amEleanor Saunders (University of Melbourne, Australia)
"Delineating the Essential Role of Glucose Uptake and Metabolism in Leishmania Infectivity"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amAlassane Mbengue (University of Notre Dame, USA)
"Malarial Phosphoinositide Detection in Virulence and Disease"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmLaura-Isobel McCall (University of California, San Diego, USA)
"Position, Parasites and Pathways: Untargeted Metabolomics, Molecular Networking and 3-D Modeling in an Acute Model of Chagas Disease"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmPurnima Bhanot (Rutgers New Jersey Medical School, USA)
"Invasion of Hepatocytes by Plasmodium Sporozoites Requires cGMP-Dependent Protein Kinase and Calcium Dependent Protein Kinase 1 and 4"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmImmunity and Persistence
Discussion Leader: Maria Mota (Instituto de Medicina Molecular, Portugal)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmNisha Garg (University of Texas Medical Branch, USA)
"T. cruzi Manipulation of Macrophages: It Is Not All About Oxidative Burst"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmMichael Hsieh (Biomedical Research Institute, Children's National Medical Center, USA)
"Defining the Immunomodulatory Niche of Schistosome haematobium IPSE"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmDan Neafsey (Broad Institute of MIT and Harvard, USA)
"Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmJeroen Saeij (University of California, Davis, USA)
"Toxoplasma Inflammasome Activation"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmMaria Ailen Natale (Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben", Argentina)
"Chronically Trypanosoma cruzi Infected Subjects Lacking Parasite Specific T Responses Have Alterations in the IL7/IL7R Signalling Pathway"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmParasite Development, Differentiation and Transmission
Discussion Leader: Stephen Beverley (Washington University School of Medicine in St. Louis, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amFlaminia Catteruccia (Harvard T.H. Chan School of Public Health, USA)
"Natural Wolbachia Infections in Anopheles Populations: A New Factor in Malaria Transmission?"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amOliver Billker (Wellcome Trust Sanger Institute, United Kingdom)
"Plasmodium berghei Genetics of Parasite-Host Interactions"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amCoffee Break
10:30 am - 10:50 amNina Papavasiliou (Rockefeller University, USA)
"VSG Coat Replacement and the Mechanisms of Immune Evasion in the African Trypanosome"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amDavid Sacks (National Institute of Allergy and Infectious Diseases, NIH, USA)
"The Biology of Mating in Leishmania"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amEllen Yeh (Stanford University, USA)
"An Anti-Malarial Compound with a Novel Mechanism-of-Action Targeting Apicoplast Biogenesis"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amTania Rozario (University of Illinois at Urbana-Champaign, USA)
"Characterization of the Growth and Regenerative Potential of the Rat Intestinal Tapeworm, Hymenolepis diminuta, Cultured In Vitro"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmKarine Frenal (University of Geneva, Switzerland)
"Disruption of TgUNC Uncovers the Phenome of Toxoplasma gondii Myosin and a Unique Role of TgMyoI in Cell-to-Cell Communication"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmPhilipp Olias (Washington University School of Medicine, USA)
"Toxoplasma Inhibitor of STAT Transcription TgIST Associates with the Mi2/NuRD Complex and Blocks Interferon Signaling Pathways"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew Targets in Host Entry and Remodeling
Discussion Leader: John Boothroyd (Stanford University School of Medince, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmManoj Duraisingh (Harvard T.H. Chan School of Public Health, USA)
"The Identification and Targeting of Red Blood Cell Determinants of Malaria Infection"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmStefan Kappe (Center for Infectious Disease Research, USA)
"Host Cell-Parasite Interactions as Targets for Prevention of Malaria Infection"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmLuisa Figueiredo (Instituto de Medicina Molecular, Portugal)
"Trypanosoma brucei: A New Life Beyond the Bloodstream"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmAgata Zerka (Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Poland)
"Glycophorin D Homolog Is the Ancestral Receptor for Plasmodium reichenowi EBA-140 Merozoite Ligand on Chimpanzee Erythrocytes"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmJason Pinger (Rockefeller University, USA)
"VSG Coat Replacement: Dynamics of the Host-Pathogen Interface During T. brucei Infection"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter